Coagulation factors induce human skin mast cell and basophil degranulation via activation of complement 5 and the C5a receptor

Because serine proteases, such as coagulation and/or fibrinolysis factors, may convert C5 into C5a and C5b, we investigated the effect of C5 in the presence of factor VIIa, factor Xa, factor IIa, or plasmin on the degranulation of hsMCs. [...]C3 induced a slight degranulation of hsMCs even in the pr...

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Vydáno v:	Journal of allergy and clinical immunology Ročník 147; číslo 3; s. 1101 - 1104.e7
Hlavní autoři:	Yanase, Yuhki, Matsuo, Yoshimi, Takahagi, Shunsuke, Kawaguchi, Tomoko, Uchida, Kazue, Ishii, Kaori, Tanaka, Akio, Matsubara, Daiki, Ozawa, Koichiro, Hide, Michihiro
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Elsevier Inc 01.03.2021 Elsevier Limited
Témata:	Cell activation Coagulation factor VIIa Coagulation factors Complement activation Complement component C3 Complement component C5a Degranulation Fibrinolysis Histamine Leukocytes (basophilic) Plasmin Proteinase inhibitors Serine Serine proteinase Skin Stem cells Urticaria United Kingdom > UK Japan
ISSN:	0091-6749, 1097-6825, 1097-6825
On-line přístup:	Získat plný text
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