Coagulation factors induce human skin mast cell and basophil degranulation via activation of complement 5 and the C5a receptor

Because serine proteases, such as coagulation and/or fibrinolysis factors, may convert C5 into C5a and C5b, we investigated the effect of C5 in the presence of factor VIIa, factor Xa, factor IIa, or plasmin on the degranulation of hsMCs. [...]C3 induced a slight degranulation of hsMCs even in the pr...

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Vydáno v:Journal of allergy and clinical immunology Ročník 147; číslo 3; s. 1101 - 1104.e7
Hlavní autoři: Yanase, Yuhki, Matsuo, Yoshimi, Takahagi, Shunsuke, Kawaguchi, Tomoko, Uchida, Kazue, Ishii, Kaori, Tanaka, Akio, Matsubara, Daiki, Ozawa, Koichiro, Hide, Michihiro
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 01.03.2021
Elsevier Limited
Témata:
Cell activation
Coagulation factor VIIa
Coagulation factors
Complement activation
Complement component C3
Complement component C5a
Degranulation
Fibrinolysis
Histamine
Leukocytes (basophilic)
Plasmin
Proteinase inhibitors
Serine
Serine proteinase
Skin
Stem cells
Urticaria
United Kingdom > UK
Japan
ISSN:0091-6749, 1097-6825, 1097-6825
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Abstract Because serine proteases, such as coagulation and/or fibrinolysis factors, may convert C5 into C5a and C5b, we investigated the effect of C5 in the presence of factor VIIa, factor Xa, factor IIa, or plasmin on the degranulation of hsMCs. [...]C3 induced a slight degranulation of hsMCs even in the presence of factor Xa and factor IIa (Fig 1, C). [...]nafamostat mesylate, a serine protease inhibitor, reduced C5 plus IIa– and C5 plus plasmin–induced degranulation of hsMCs in a concentration-dependent manner. [...]neither C5 nor the coagulation factors Xa or IIa induced histamine release by themselves, but the combination of C5 and factor IIa or factor Xa did (Fig 2, B). To date, several articles have implied that activated coagulation factors, such as Xa and IIa, directly activate hsMCs via PAR1 or PAR2 in CSU.9 Although we could not rule out the involvement of PARs for mast cell and basophil activation on account of the experiments having a small number of subjects, we demonstrated that C5a resulting from the extrinsic coagulation system induces degranulation of hsMCs and basophils via C5aR. [...]we established an alternative hypothesis of mast cell and/or basophil activation through the coagulation pathway and complement (see Fig E6 in this article's Online Repository at www.jacionline.org).
AbstractList Because serine proteases, such as coagulation and/or fibrinolysis factors, may convert C5 into C5a and C5b, we investigated the effect of C5 in the presence of factor VIIa, factor Xa, factor IIa, or plasmin on the degranulation of hsMCs. [...]C3 induced a slight degranulation of hsMCs even in the presence of factor Xa and factor IIa (Fig 1, C). [...]nafamostat mesylate, a serine protease inhibitor, reduced C5 plus IIa– and C5 plus plasmin–induced degranulation of hsMCs in a concentration-dependent manner. [...]neither C5 nor the coagulation factors Xa or IIa induced histamine release by themselves, but the combination of C5 and factor IIa or factor Xa did (Fig 2, B). To date, several articles have implied that activated coagulation factors, such as Xa and IIa, directly activate hsMCs via PAR1 or PAR2 in CSU.9 Although we could not rule out the involvement of PARs for mast cell and basophil activation on account of the experiments having a small number of subjects, we demonstrated that C5a resulting from the extrinsic coagulation system induces degranulation of hsMCs and basophils via C5aR. [...]we established an alternative hypothesis of mast cell and/or basophil activation through the coagulation pathway and complement (see Fig E6 in this article's Online Repository at www.jacionline.org).
Author Uchida, Kazue
Takahagi, Shunsuke
Ozawa, Koichiro
Matsubara, Daiki
Kawaguchi, Tomoko
Hide, Michihiro
Tanaka, Akio
Yanase, Yuhki
Matsuo, Yoshimi
Ishii, Kaori
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  surname: Yanase
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  fullname: Kawaguchi, Tomoko
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  organization: Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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  fullname: Matsubara, Daiki
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  givenname: Koichiro
  surname: Ozawa
  fullname: Ozawa, Koichiro
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  surname: Hide
  fullname: Hide, Michihiro
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  organization: Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32888945$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1111/j.1398-9995.2009.02222.x
10.3389/fimmu.2018.00689
10.1016/j.alit.2017.09.003
10.4168/aair.2019.11.4.470
10.1016/j.jaci.2017.07.026
10.1016/j.anai.2019.08.014
10.1111/all.13555
10.1186/s13223-019-0372-z
10.1038/sj.jid.5700169
10.1111/all.14110
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References Min, Saini (bib1) 2019; 11
Kolkhir, Altrichter, Munoz, Hawro, Maurer (bib2) 2020; 124
Saito, Yanase, Kamegashira, Takahagi, Tanaka, Uchida (bib8) 2020; 75
Takahagi, Mihara, Iwamoto, Morioke, Okabe, Kameyoshi (bib5) 2010; 65
Yanase, Morioke, Iwamoto, Takahagi, Uchida, Kawaguchi (bib7) 2018; 141
Yanase, Takahagi, Hide (bib6) 2018; 67
Moormann, Artuc, Pohl, Varga, Buddenkotte, Vergnolle (bib9) 2006; 126
Maurer, Altrichter, Schmetzer, Scheffel, Church, Metz (bib4) 2018; 9
Bansal, Bansal (bib3) 2019; 15
Yanase (10.1016/j.jaci.2020.08.018_bib6) 2018; 67
Maurer (10.1016/j.jaci.2020.08.018_bib4) 2018; 9
Moormann (10.1016/j.jaci.2020.08.018_bib9) 2006; 126
Min (10.1016/j.jaci.2020.08.018_bib1) 2019; 11
Matsuo (10.1016/j.jaci.2020.08.018_bib10) 2018; 73
Kolkhir (10.1016/j.jaci.2020.08.018_bib2) 2020; 124
Yanase (10.1016/j.jaci.2020.08.018_bib7) 2018; 141
Bansal (10.1016/j.jaci.2020.08.018_bib3) 2019; 15
Saito (10.1016/j.jaci.2020.08.018_bib8) 2020; 75
Takahagi (10.1016/j.jaci.2020.08.018_bib5) 2010; 65
References_xml – volume: 15
  start-page: 56
  year: 2019
  ident: bib3
  article-title: Stress, pseudoallergens, autoimmunity, infection and inflammation in chronic spontaneous urticaria
  publication-title: Allergy Asthma Clin Immunol
– volume: 67
  start-page: 191
  year: 2018
  end-page: 194
  ident: bib6
  article-title: Chronic spontaneous urticaria and the extrinsic coagulation system
  publication-title: Allergol Int
– volume: 126
  start-page: 746
  year: 2006
  end-page: 755
  ident: bib9
  article-title: Functional characterization and expression analysis of the proteinase-activated receptor-2 in human cutaneous mast cells
  publication-title: J Invest Dermatol
– volume: 124
  start-page: 2
  year: 2020
  end-page: 12
  ident: bib2
  article-title: New treatments for chronic urticaria
  publication-title: Ann Allergy Asthma Immunol
– volume: 9
  start-page: 689
  year: 2018
  ident: bib4
  article-title: Immunoglobulin E-mediated autoimmunity
  publication-title: Front Immunol
– volume: 65
  start-page: 649
  year: 2010
  end-page: 656
  ident: bib5
  article-title: Coagulation/fibrinolysis and inflammation markers are associated with disease activity in patients with chronic urticaria
  publication-title: Allergy
– volume: 75
  start-page: 971
  year: 2020
  end-page: 974
  ident: bib8
  article-title: Increase of tissue factor expression on the surface of peripheral monocytes of patients with chronic spontaneous urticaria
  publication-title: Allergy
– volume: 141
  start-page: 1115
  year: 2018
  end-page: 1118
  ident: bib7
  article-title: Histamine and TLR ligands synergistically induce endothelial-cell gap-formation by the extrinsic coagulating pathway
  publication-title: J Allergy Clin Immunol
– volume: 11
  start-page: 470
  year: 2019
  end-page: 481
  ident: bib1
  article-title: Emerging therapies in chronic spontaneous urticaria
  publication-title: Allergy Asthma Immunol Res
– volume: 65
  start-page: 649
  year: 2010
  ident: 10.1016/j.jaci.2020.08.018_bib5
  article-title: Coagulation/fibrinolysis and inflammation markers are associated with disease activity in patients with chronic urticaria
  publication-title: Allergy
  doi: 10.1111/j.1398-9995.2009.02222.x
– volume: 9
  start-page: 689
  year: 2018
  ident: 10.1016/j.jaci.2020.08.018_bib4
  article-title: Immunoglobulin E-mediated autoimmunity
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2018.00689
– volume: 67
  start-page: 191
  year: 2018
  ident: 10.1016/j.jaci.2020.08.018_bib6
  article-title: Chronic spontaneous urticaria and the extrinsic coagulation system
  publication-title: Allergol Int
  doi: 10.1016/j.alit.2017.09.003
– volume: 11
  start-page: 470
  year: 2019
  ident: 10.1016/j.jaci.2020.08.018_bib1
  article-title: Emerging therapies in chronic spontaneous urticaria
  publication-title: Allergy Asthma Immunol Res
  doi: 10.4168/aair.2019.11.4.470
– volume: 141
  start-page: 1115
  year: 2018
  ident: 10.1016/j.jaci.2020.08.018_bib7
  article-title: Histamine and TLR ligands synergistically induce endothelial-cell gap-formation by the extrinsic coagulating pathway
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2017.07.026
– volume: 124
  start-page: 2
  year: 2020
  ident: 10.1016/j.jaci.2020.08.018_bib2
  article-title: New treatments for chronic urticaria
  publication-title: Ann Allergy Asthma Immunol
  doi: 10.1016/j.anai.2019.08.014
– volume: 73
  start-page: 2256
  year: 2018
  ident: 10.1016/j.jaci.2020.08.018_bib10
  article-title: Neuromedin U directly induces degranulation of skin mast cells, presumably via MRGPRX2
  publication-title: Allergy
  doi: 10.1111/all.13555
– volume: 15
  start-page: 56
  year: 2019
  ident: 10.1016/j.jaci.2020.08.018_bib3
  article-title: Stress, pseudoallergens, autoimmunity, infection and inflammation in chronic spontaneous urticaria
  publication-title: Allergy Asthma Clin Immunol
  doi: 10.1186/s13223-019-0372-z
– volume: 126
  start-page: 746
  year: 2006
  ident: 10.1016/j.jaci.2020.08.018_bib9
  article-title: Functional characterization and expression analysis of the proteinase-activated receptor-2 in human cutaneous mast cells
  publication-title: J Invest Dermatol
  doi: 10.1038/sj.jid.5700169
– volume: 75
  start-page: 971
  year: 2020
  ident: 10.1016/j.jaci.2020.08.018_bib8
  article-title: Increase of tissue factor expression on the surface of peripheral monocytes of patients with chronic spontaneous urticaria
  publication-title: Allergy
  doi: 10.1111/all.14110
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Snippet Because serine proteases, such as coagulation and/or fibrinolysis factors, may convert C5 into C5a and C5b, we investigated the effect of C5 in the presence of...
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SubjectTerms Cell activation
Coagulation factor VIIa
Coagulation factors
Complement activation
Complement component C3
Complement component C5a
Degranulation
Fibrinolysis
Histamine
Leukocytes (basophilic)
Plasmin
Proteinase inhibitors
Serine
Serine proteinase
Skin
Stem cells
Urticaria
Title Coagulation factors induce human skin mast cell and basophil degranulation via activation of complement 5 and the C5a receptor
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