Effect of colonoscopy screening on risks of colorectal cancer and related death: instrumental variable estimation of per-protocol effects

Background We recently reported per-protocol estimates of colonoscopy screening on colorectal cancer incidence and mortality in NordICC, a large-scale randomized trial. Our results may be affected by residual confounding due to lack of detailed information on confounders. Here, we supplement our per...

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Vydané v:European journal of epidemiology Ročník 40; číslo 4; s. 419 - 425
Hlavní autori: Shi, Joy, Løberg, Magnus, Kalager, Mette, Wieszczy, Paulina, Pilonis, Nastazja D., Adami, Hans-Olov, Kaminski, Michal F., Bretthauer, Michael, Hernán, Miguel A.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Dordrecht Springer Netherlands 01.04.2025
Springer Nature B.V
Predmet:
Aged
Cancer
Cardiology
Clinical outcomes
Clinical trials
Colonoscopy
Colonoscopy - statistics & numerical data
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - mortality
Colorectal Neoplasms - prevention & control
Confidence intervals
Disease prevention
Early Detection of Cancer - methods
Epidemiology
Estimates
Female
Health risks
Humans
Incidence
Infectious Diseases
Male
Mass Screening - methods
Medical screening
Medicine
Medicine & Public Health
Middle Aged
Mortality
Oncology
Public Health
Risk
Risk Factors
Screening
Instrumental variable
Screening
Per-protocol
Colonoscopy
Colorectal cancer
ISSN:0393-2990, 1573-7284, 1573-7284
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Abstract Background We recently reported per-protocol estimates of colonoscopy screening on colorectal cancer incidence and mortality in NordICC, a large-scale randomized trial. Our results may be affected by residual confounding due to lack of detailed information on confounders. Here, we supplement our per-protocol analyses with instrumental variable (IV) estimates whose validity relies on an alternate set of assumptions but does not depend on the availability of confounder data. Individuals in the NordICC trial were randomized at a 1:2 ratio to receive either an invitation to a one-time screening colonoscopy (the invited group) or no invitation (the usual-care group). We used IV analyses to estimate bounds and point estimates of per-protocol effects of colonoscopy screening on colorectal cancer incidence and mortality after 10 years follow-up. Analyses included 28,220 participants in the invited group and 56,365 participants in the usual-care group. Participation in screening was 42%. In IV per-protocol analyses, the 10-year risk of colorectal cancer was 1.13% (95% confidence interval [CI]: 1.04, 1.23) with usual care and, depending on the assumptions, 0.66% (95% CI: 035, 0.95) to 0.74% (95% CI: 0.57, 0.95) in screened individuals (risk ratio of 0.59 [95% CI: 0.30, 0.98] to 0.65 [95% CI: 0.48, 0.87]). The risk of colorectal cancer mortality at 10 years was 0.29% (95% CI: 0.24, 0.33) in the usual-care group and 0.20 (95% CI: 0.09, 0.73) to 0.22% (95% CI: 0.08, 0.37) in the screened group (risk ratio of 0.71 [95% CI: 0.31, 2.89] to 0.79 [95% CI: 0.24, 1.42]). IV estimation of per-protocol effects suggests that colonoscopy screening reduces colorectal cancer incidence by 35 to 41% after 10 years.
AbstractList We recently reported per-protocol estimates of colonoscopy screening on colorectal cancer incidence and mortality in NordICC, a large-scale randomized trial. Our results may be affected by residual confounding due to lack of detailed information on confounders. Here, we supplement our per-protocol analyses with instrumental variable (IV) estimates whose validity relies on an alternate set of assumptions but does not depend on the availability of confounder data. Individuals in the NordICC trial were randomized at a 1:2 ratio to receive either an invitation to a one-time screening colonoscopy (the invited group) or no invitation (the usual-care group). We used IV analyses to estimate bounds and point estimates of per-protocol effects of colonoscopy screening on colorectal cancer incidence and mortality after 10 years follow-up. Analyses included 28,220 participants in the invited group and 56,365 participants in the usual-care group. Participation in screening was 42%. In IV per-protocol analyses, the 10-year risk of colorectal cancer was 1.13% (95% confidence interval [CI]: 1.04, 1.23) with usual care and, depending on the assumptions, 0.66% (95% CI: 035, 0.95) to 0.74% (95% CI: 0.57, 0.95) in screened individuals (risk ratio of 0.59 [95% CI: 0.30, 0.98] to 0.65 [95% CI: 0.48, 0.87]). The risk of colorectal cancer mortality at 10 years was 0.29% (95% CI: 0.24, 0.33) in the usual-care group and 0.20 (95% CI: 0.09, 0.73) to 0.22% (95% CI: 0.08, 0.37) in the screened group (risk ratio of 0.71 [95% CI: 0.31, 2.89] to 0.79 [95% CI: 0.24, 1.42]). IV estimation of per-protocol effects suggests that colonoscopy screening reduces colorectal cancer incidence by 35 to 41% after 10 years.
We recently reported per-protocol estimates of colonoscopy screening on colorectal cancer incidence and mortality in NordICC, a large-scale randomized trial. Our results may be affected by residual confounding due to lack of detailed information on confounders. Here, we supplement our per-protocol analyses with instrumental variable (IV) estimates whose validity relies on an alternate set of assumptions but does not depend on the availability of confounder data. Individuals in the NordICC trial were randomized at a 1:2 ratio to receive either an invitation to a one-time screening colonoscopy (the invited group) or no invitation (the usual-care group). We used IV analyses to estimate bounds and point estimates of per-protocol effects of colonoscopy screening on colorectal cancer incidence and mortality after 10 years follow-up. Analyses included 28,220 participants in the invited group and 56,365 participants in the usual-care group. Participation in screening was 42%. In IV per-protocol analyses, the 10-year risk of colorectal cancer was 1.13% (95% confidence interval [CI]: 1.04, 1.23) with usual care and, depending on the assumptions, 0.66% (95% CI: 035, 0.95) to 0.74% (95% CI: 0.57, 0.95) in screened individuals (risk ratio of 0.59 [95% CI: 0.30, 0.98] to 0.65 [95% CI: 0.48, 0.87]). The risk of colorectal cancer mortality at 10 years was 0.29% (95% CI: 0.24, 0.33) in the usual-care group and 0.20 (95% CI: 0.09, 0.73) to 0.22% (95% CI: 0.08, 0.37) in the screened group (risk ratio of 0.71 [95% CI: 0.31, 2.89] to 0.79 [95% CI: 0.24, 1.42]). IV estimation of per-protocol effects suggests that colonoscopy screening reduces colorectal cancer incidence by 35 to 41% after 10 years.BACKGROUNDWe recently reported per-protocol estimates of colonoscopy screening on colorectal cancer incidence and mortality in NordICC, a large-scale randomized trial. Our results may be affected by residual confounding due to lack of detailed information on confounders. Here, we supplement our per-protocol analyses with instrumental variable (IV) estimates whose validity relies on an alternate set of assumptions but does not depend on the availability of confounder data. Individuals in the NordICC trial were randomized at a 1:2 ratio to receive either an invitation to a one-time screening colonoscopy (the invited group) or no invitation (the usual-care group). We used IV analyses to estimate bounds and point estimates of per-protocol effects of colonoscopy screening on colorectal cancer incidence and mortality after 10 years follow-up. Analyses included 28,220 participants in the invited group and 56,365 participants in the usual-care group. Participation in screening was 42%. In IV per-protocol analyses, the 10-year risk of colorectal cancer was 1.13% (95% confidence interval [CI]: 1.04, 1.23) with usual care and, depending on the assumptions, 0.66% (95% CI: 035, 0.95) to 0.74% (95% CI: 0.57, 0.95) in screened individuals (risk ratio of 0.59 [95% CI: 0.30, 0.98] to 0.65 [95% CI: 0.48, 0.87]). The risk of colorectal cancer mortality at 10 years was 0.29% (95% CI: 0.24, 0.33) in the usual-care group and 0.20 (95% CI: 0.09, 0.73) to 0.22% (95% CI: 0.08, 0.37) in the screened group (risk ratio of 0.71 [95% CI: 0.31, 2.89] to 0.79 [95% CI: 0.24, 1.42]). IV estimation of per-protocol effects suggests that colonoscopy screening reduces colorectal cancer incidence by 35 to 41% after 10 years.
Background We recently reported per-protocol estimates of colonoscopy screening on colorectal cancer incidence and mortality in NordICC, a large-scale randomized trial. Our results may be affected by residual confounding due to lack of detailed information on confounders. Here, we supplement our per-protocol analyses with instrumental variable (IV) estimates whose validity relies on an alternate set of assumptions but does not depend on the availability of confounder data. Individuals in the NordICC trial were randomized at a 1:2 ratio to receive either an invitation to a one-time screening colonoscopy (the invited group) or no invitation (the usual-care group). We used IV analyses to estimate bounds and point estimates of per-protocol effects of colonoscopy screening on colorectal cancer incidence and mortality after 10 years follow-up. Analyses included 28,220 participants in the invited group and 56,365 participants in the usual-care group. Participation in screening was 42%. In IV per-protocol analyses, the 10-year risk of colorectal cancer was 1.13% (95% confidence interval [CI]: 1.04, 1.23) with usual care and, depending on the assumptions, 0.66% (95% CI: 035, 0.95) to 0.74% (95% CI: 0.57, 0.95) in screened individuals (risk ratio of 0.59 [95% CI: 0.30, 0.98] to 0.65 [95% CI: 0.48, 0.87]). The risk of colorectal cancer mortality at 10 years was 0.29% (95% CI: 0.24, 0.33) in the usual-care group and 0.20 (95% CI: 0.09, 0.73) to 0.22% (95% CI: 0.08, 0.37) in the screened group (risk ratio of 0.71 [95% CI: 0.31, 2.89] to 0.79 [95% CI: 0.24, 1.42]). IV estimation of per-protocol effects suggests that colonoscopy screening reduces colorectal cancer incidence by 35 to 41% after 10 years.
BackgroundWe recently reported per-protocol estimates of colonoscopy screening on colorectal cancer incidence and mortality in NordICC, a large-scale randomized trial. Our results may be affected by residual confounding due to lack of detailed information on confounders. Here, we supplement our per-protocol analyses with instrumental variable (IV) estimates whose validity relies on an alternate set of assumptions but does not depend on the availability of confounder data. Individuals in the NordICC trial were randomized at a 1:2 ratio to receive either an invitation to a one-time screening colonoscopy (the invited group) or no invitation (the usual-care group). We used IV analyses to estimate bounds and point estimates of per-protocol effects of colonoscopy screening on colorectal cancer incidence and mortality after 10 years follow-up. Analyses included 28,220 participants in the invited group and 56,365 participants in the usual-care group. Participation in screening was 42%. In IV per-protocol analyses, the 10-year risk of colorectal cancer was 1.13% (95% confidence interval [CI]: 1.04, 1.23) with usual care and, depending on the assumptions, 0.66% (95% CI: 035, 0.95) to 0.74% (95% CI: 0.57, 0.95) in screened individuals (risk ratio of 0.59 [95% CI: 0.30, 0.98] to 0.65 [95% CI: 0.48, 0.87]). The risk of colorectal cancer mortality at 10 years was 0.29% (95% CI: 0.24, 0.33) in the usual-care group and 0.20 (95% CI: 0.09, 0.73) to 0.22% (95% CI: 0.08, 0.37) in the screened group (risk ratio of 0.71 [95% CI: 0.31, 2.89] to 0.79 [95% CI: 0.24, 1.42]). IV estimation of per-protocol effects suggests that colonoscopy screening reduces colorectal cancer incidence by 35 to 41% after 10 years.
Author Adami, Hans-Olov
Pilonis, Nastazja D.
Kalager, Mette
Wieszczy, Paulina
Løberg, Magnus
Hernán, Miguel A.
Kaminski, Michal F.
Bretthauer, Michael
Shi, Joy
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Cites_doi 10.1056/NEJMoa1114635
10.1056/NEJMsm1605385
10.1097/EDE.0000000000000469
10.1002/sim.8471
10.1111/rssb.12262
10.1056/NEJMoa2208375
10.1055/s-0032-1306895
10.1001/jama.2014.8266
10.1093/jnci/djr284
10.1001/jamainternmed.2016.0960
10.1056/NEJMc2215192
10.1097/01.ede.0000222409.00878.37
10.1186/s13063-015-1056-8
10.1016/S0140-6736(10)60551-X
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Issue 4
Keywords Instrumental variable
Screening
Per-protocol
Colonoscopy
Colorectal cancer
Language English
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References M Bretthauer (1209_CR1) 2022; 387
MA Hernán (1209_CR3) 2017; 377
JG Young (1209_CR8) 2020; 39
Ø Holme (1209_CR10) 2014; 312
N Segnan (1209_CR13) 2011; 103
RE Schoen (1209_CR12) 2012; 366
MA Hernán (1209_CR4) 2006; 17
MA Hernán (1209_CR15) 2021
M Bretthauer (1209_CR6) 2016; 176
M Løberg (1209_CR7) 2016; 27
SA Swanson (1209_CR9) 2015; 16
MF Kaminski (1209_CR5) 2012; 44
JA Hanley (1209_CR2) 2023; 388
WS Atkin (1209_CR11) 2010; 375
L Wang (1209_CR14) 2018; 80
References_xml – volume: 366
  start-page: 2345
  year: 2012
  ident: 1209_CR12
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1114635
– volume: 377
  start-page: 1391
  year: 2017
  ident: 1209_CR3
  publication-title: N Engl J Med
  doi: 10.1056/NEJMsm1605385
– volume: 27
  start-page: 393
  year: 2016
  ident: 1209_CR7
  publication-title: Epidemiology
  doi: 10.1097/EDE.0000000000000469
– volume: 39
  start-page: 1199
  year: 2020
  ident: 1209_CR8
  publication-title: Stat Med
  doi: 10.1002/sim.8471
– volume: 80
  start-page: 531
  year: 2018
  ident: 1209_CR14
  publication-title: J R Stat Soc Series B Stat Methodol
  doi: 10.1111/rssb.12262
– volume: 387
  start-page: 1547
  year: 2022
  ident: 1209_CR1
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2208375
– volume: 44
  start-page: 695
  year: 2012
  ident: 1209_CR5
  publication-title: Endoscopy
  doi: 10.1055/s-0032-1306895
– volume: 312
  start-page: 606
  year: 2014
  ident: 1209_CR10
  publication-title: JAMA
  doi: 10.1001/jama.2014.8266
– volume: 103
  start-page: 1310
  year: 2011
  ident: 1209_CR13
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/djr284
– volume: 176
  start-page: 894
  year: 2016
  ident: 1209_CR6
  publication-title: JAMA Intern Med
  doi: 10.1001/jamainternmed.2016.0960
– volume: 388
  start-page: 376
  year: 2023
  ident: 1209_CR2
  publication-title: N Engl J Med
  doi: 10.1056/NEJMc2215192
– volume: 17
  start-page: 360
  year: 2006
  ident: 1209_CR4
  publication-title: Epidemiology
  doi: 10.1097/01.ede.0000222409.00878.37
– volume: 16
  start-page: 541
  year: 2015
  ident: 1209_CR9
  publication-title: Trials
  doi: 10.1186/s13063-015-1056-8
– volume: 375
  start-page: 1624
  year: 2010
  ident: 1209_CR11
  publication-title: Lancet
  doi: 10.1016/S0140-6736(10)60551-X
– volume-title: Causal Inference: What If
  year: 2021
  ident: 1209_CR15
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Snippet Background We recently reported per-protocol estimates of colonoscopy screening on colorectal cancer incidence and mortality in NordICC, a large-scale...
We recently reported per-protocol estimates of colonoscopy screening on colorectal cancer incidence and mortality in NordICC, a large-scale randomized trial....
BackgroundWe recently reported per-protocol estimates of colonoscopy screening on colorectal cancer incidence and mortality in NordICC, a large-scale...
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SubjectTerms Aged
Cancer
Cardiology
Clinical outcomes
Clinical trials
Colonoscopy
Colonoscopy - statistics & numerical data
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - mortality
Colorectal Neoplasms - prevention & control
Confidence intervals
Disease prevention
Early Detection of Cancer - methods
Epidemiology
Estimates
Female
Health risks
Humans
Incidence
Infectious Diseases
Male
Mass Screening - methods
Medical screening
Medicine
Medicine & Public Health
Middle Aged
Mortality
Oncology
Public Health
Risk
Risk Factors
Screening
Title Effect of colonoscopy screening on risks of colorectal cancer and related death: instrumental variable estimation of per-protocol effects
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