Parkin paves the path to antitumor immunity: Expanding Parkin’s role as a tumor suppressor
Parkin, a ring-between-ring-type E3 ubiquitin ligase, first shown to play a critical role in autosomal recessive juvenile Parkinsonism, has recently emerged as a key player in cancer biology. Parkin is now known to serve as a tumor suppressor, and its deregulation frequently promotes tumorigenesis....
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| Vydáno v: | The Journal of clinical investigation Ročník 134; číslo 22; s. 1 - 3 |
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| Hlavní autoři: | , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
American Society for Clinical Investigation
15.11.2024
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| Témata: | |
| ISSN: | 1558-8238, 0021-9738, 1558-8238 |
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| Abstract | Parkin, a ring-between-ring-type E3 ubiquitin ligase, first shown to play a critical role in autosomal recessive juvenile Parkinsonism, has recently emerged as a key player in cancer biology. Parkin is now known to serve as a tumor suppressor, and its deregulation frequently promotes tumorigenesis. In this issue of the JCI, Perego et al. expand that role by showing that Parkin expression stimulated an interferon (IFN) response to modulate CD8+ T cell activity. These findings suggest that, in addition to directly inhibiting tumor progression, Parkin enhances antitumor immune responses, highlighting it as a promising therapeutic target for cancer treatment. |
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| AbstractList | Parkin, a ring-between-ring-type E3 ubiquitin ligase, first shown to play a critical role in autosomal recessive juvenile Parkinsonism, has recently emerged as a key player in cancer biology. Parkin is now known to serve as a tumor suppressor, and its deregulation frequently promotes tumorigenesis. In this issue of the JCI, Perego et al. expand that role by showing that Parkin expression stimulated an interferon (IFN) response to modulate CD8+ T cell activity. These findings suggest that, in addition to directly inhibiting tumor progression, Parkin enhances antitumor immune responses, highlighting it as a promising therapeutic target for cancer treatment.Parkin, a ring-between-ring-type E3 ubiquitin ligase, first shown to play a critical role in autosomal recessive juvenile Parkinsonism, has recently emerged as a key player in cancer biology. Parkin is now known to serve as a tumor suppressor, and its deregulation frequently promotes tumorigenesis. In this issue of the JCI, Perego et al. expand that role by showing that Parkin expression stimulated an interferon (IFN) response to modulate CD8+ T cell activity. These findings suggest that, in addition to directly inhibiting tumor progression, Parkin enhances antitumor immune responses, highlighting it as a promising therapeutic target for cancer treatment. Parkin, a ring-between-ring-type E3 ubiquitin ligase, first shown to play a critical role in autosomal recessive juvenile Parkinsonism, has recently emerged as a key player in cancer biology. Parkin is now known to serve as a tumor suppressor, and its deregulation frequently promotes tumorigenesis. In this issue of the JCI, Perego et al. expand that role by showing that Parkin expression stimulated an interferon (IFN) response to modulate CD8+ T cell activity. These findings suggest that, in addition to directly inhibiting tumor progression, Parkin enhances antitumor immune responses, highlighting it as a promising therapeutic target for cancer treatment. Parkin, a ring-between-ring-type E3 ubiquitin ligase, first shown to play a critical role in autosomal recessive juvenile Parkinsonism, has recently emerged as a key player in cancer biology. Parkin is now known to serve as a tumor suppressor, and its deregulation frequently promotes tumorigenesis. In this issue of theJCI, Perego et al. expand that role by showing that Parkin expression stimulated an interferon (IFN) response to modulate [CD8.sup.+] T cell activity. These findings suggest that, in addition to directly inhibiting tumor progression, Parkin enhances antitumor immune responses, highlighting it as a promising therapeutic target for cancer treatment. Departments of Surgery and Biomedical Sciences, Translational Research Institute, Cedars Sinai Medical Center, Los Angeles, USA. |
| Audience | Academic |
| Author | Kim, Hyungsoo Ronai, Ze’ev A. |
| AuthorAffiliation | Departments of Surgery and Biomedical Sciences, Translational Research Institute, Cedars Sinai Medical Center, Los Angeles, USA |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39545411$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.isci.2019.06.008 10.1038/33416 10.1016/j.neuroscience.2014.10.028 10.1038/77060 10.1038/nri.2017.142 10.1016/j.immuni.2018.12.021 10.1038/s41590-023-01569-z 10.1038/s41586-018-0448-9 10.1038/s41577-019-0224-6 10.1038/s41590-019-0312-6 10.1126/sciadv.abg7287 10.1126/sciimmunol.abb9726 10.1172/JCI180983 10.1172/JCI26322 10.1016/j.bbcan.2021.188533 |
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| Snippet | Parkin, a ring-between-ring-type E3 ubiquitin ligase, first shown to play a critical role in autosomal recessive juvenile Parkinsonism, has recently emerged as... Departments of Surgery and Biomedical Sciences, Translational Research Institute, Cedars Sinai Medical Center, Los Angeles, USA. |
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| SubjectTerms | Animals Cancer Cancer therapies Care and treatment CD8-Positive T-Lymphocytes - immunology Cell cycle Deregulation Development and progression Epigenetics Health aspects Humans Immune response Immunity (Disease) Inflammation Interferon Ligases Lymphocytes Metabolism Metastasis Mice Motility Mutation Neoplasms - genetics Neoplasms - immunology Parkin protein Parkinson's disease Quality control T cells Tumor suppressor genes Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - immunology Tumor Suppressor Proteins - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - immunology Ubiquitin-Protein Ligases - metabolism |
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| Title | Parkin paves the path to antitumor immunity: Expanding Parkin’s role as a tumor suppressor |
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