Doxorubicin-Loaded Magnetic Silk Fibroin Nanoparticles for Targeted Therapy of Multidrug-Resistant Cancer

A strategy to prepare doxorubicin‐loaded magnetic silk fibroin nanoparticles is presented. The nanoparticles serve as a nanometer‐scale drug‐delivery system in the chemotherapy of multidrug‐resistant cancer under the guidance of a magnetic field. The magnetic tumor‐targeting ability broadens the ran...

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Veröffentlicht in:Advanced materials (Weinheim) Jg. 26; H. 43; S. 7393 - 7398
Hauptverfasser: Tian, Ye, Jiang, Xuejiao, Chen, Xin, Shao, Zhengzhong, Yang, Wuli
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Germany Blackwell Publishing Ltd 19.11.2014
Schlagworte:
Animals
Antineoplastic Agents - administration & dosage
Biomedical materials
Bombyx
Cancer
Cell Line, Tumor
Cell Survival - drug effects
Doxorubicin - chemistry
drug delivery
Drug Delivery Systems - methods
Drug Resistance, Neoplasm
Female
Ferric Compounds - chemistry
Fibroins - chemistry
Humans
Hydrogen-Ion Concentration
Hydrophobic and Hydrophilic Interactions
Magnetic Fields
magnetic guidance
Magnets - chemistry
Mice, Inbred BALB C
Mice, Nude
Nanoparticles
Nanoparticles - chemistry
Nanostructure
Neoplasm Transplantation
Silk fibroin
Static Electricity
Strategy
Therapy
magnetic guidance
nanoparticles
drug delivery
silk fibroin
ISSN:0935-9648, 1521-4095, 1521-4095
Online-Zugang:Volltext
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Zusammenfassung:A strategy to prepare doxorubicin‐loaded magnetic silk fibroin nanoparticles is presented. The nanoparticles serve as a nanometer‐scale drug‐delivery system in the chemotherapy of multidrug‐resistant cancer under the guidance of a magnetic field. The magnetic tumor‐targeting ability broadens the range of biomedical applications of silk fibroin, and the nanoparticle‐assisted preparation strategy is useful for the advancement of other biomacromolecule‐based materials.
Bibliographie:ArticleID:ADMA201403562
istex:24CE587FFD2DCBE28C3B3E15E82CF55DF1B0C33C
National Science Foundation of China - No. 20874015; No. 51273047
ark:/67375/WNG-MZMNRDH0-X
"Shu Guang" - No. 12SG07
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0935-9648
1521-4095
1521-4095
DOI:10.1002/adma.201403562