IL-4/JAK/STAT6 pathway activation in follicle center lymphoma of the lower female genital tract: A case report

Follicle center lymphoma (FCL) of the lower female genital tract (LFGT) is a recently proposed subtype of B-cell lymphoma that resembles primary cutaneous follicle center lymphoma. Although targeted next-generation sequencing (NGS) studies have identified recurrent TNFRSF14 mutations in FCL of the L...

Full description

Saved in:

Bibliographic Details
Published in:	Human Pathology Reports Vol. 42; p. 300805
Main Authors:	Kitaoka, Takumi, Satou, Akira, Kitamura, Eiichi, Aizawa, Keiko, Sudo, Takeshi, Abe, Madoka, Kabasawa, Takanobu, Suzuki, Kazushi, Uchiyama, Naoya, Ohe, Rintaro
Format:	Journal Article
Language:	English
Published:	Elsevier Inc 01.11.2025 Elsevier
Subjects:	Follicle center lymphoma of the lower female genital tract IL4R Pathology SOCS3 TNFRSF14 Whole-exome sequencing SOCS3 TNFRSF14 IL4R Whole-exome sequencing Follicle center lymphoma of the lower female genital tract
ISSN:	2772-736X, 2772-736X
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Follicle center lymphoma (FCL) of the lower female genital tract (LFGT) is a recently proposed subtype of B-cell lymphoma that resembles primary cutaneous follicle center lymphoma. Although targeted next-generation sequencing (NGS) studies have identified recurrent TNFRSF14 mutations in FCL of the LFGT, its broader mutational landscape remains largely uncharacterized. We report a case of FCL of the LFGT in a woman in her 40s presenting with a cervical tumor. Histological examination revealed a predominantly diffuse proliferation of CD20+, CD79a+, BCL6+, HGAL+, CD23+, and BCL2− atypical lymphocytes, consistent with a centrocytic phenotype. Numerous T follicular helper cells were observed in the background of the lesion. Whole-exome sequencing identified 1,336 coding variants. After filtering based on tumor cell content and CADD phred score (≥20), 125 variants were retained, including a nonsense mutation in TNFRSF14 and missense mutations in IL4R and SOCS3. The TNFRSF14 mutation may contribute to the accumulation and activation of T follicular helper cells by disrupting the inhibitory HVEM–BTLA signaling pathway. In addition, IL4R and SOCS3 mutations may lead to upregulation of the IL-4/JAK/STAT6 pathway, promoting tumor cell survival and proliferation. These findings provide new insights into the molecular pathogenesis of FCL of the LFGT.
AbstractList	Follicle center lymphoma (FCL) of the lower female genital tract (LFGT) is a recently proposed subtype of B-cell lymphoma that resembles primary cutaneous follicle center lymphoma. Although targeted next-generation sequencing (NGS) studies have identified recurrent TNFRSF14 mutations in FCL of the LFGT, its broader mutational landscape remains largely uncharacterized. We report a case of FCL of the LFGT in a woman in her 40s presenting with a cervical tumor. Histological examination revealed a predominantly diffuse proliferation of CD20+, CD79a+, BCL6+, HGAL+, CD23+, and BCL2− atypical lymphocytes, consistent with a centrocytic phenotype. Numerous T follicular helper cells were observed in the background of the lesion. Whole-exome sequencing identified 1,336 coding variants. After filtering based on tumor cell content and CADD phred score (≥20), 125 variants were retained, including a nonsense mutation in TNFRSF14 and missense mutations in IL4R and SOCS3. The TNFRSF14 mutation may contribute to the accumulation and activation of T follicular helper cells by disrupting the inhibitory HVEM–BTLA signaling pathway. In addition, IL4R and SOCS3 mutations may lead to upregulation of the IL-4/JAK/STAT6 pathway, promoting tumor cell survival and proliferation. These findings provide new insights into the molecular pathogenesis of FCL of the LFGT. AbstractFollicle center lymphoma (FCL) of the lower female genital tract (LFGT) is a recently proposed subtype of B-cell lymphoma that resembles primary cutaneous follicle center lymphoma. Although targeted next-generation sequencing (NGS) studies have identified recurrent TNFRSF14 mutations in FCL of the LFGT, its broader mutational landscape remains largely uncharacterized. We report a case of FCL of the LFGT in a woman in her 40s presenting with a cervical tumor. Histological examination revealed a predominantly diffuse proliferation of CD20 +, CD79a +, BCL6 +, HGAL +, CD23 +, and BCL2 − atypical lymphocytes, consistent with a centrocytic phenotype. Numerous T follicular helper cells were observed in the background of the lesion. Whole-exome sequencing identified 1,336 coding variants. After filtering based on tumor cell content and CADD phred score (≥20), 125 variants were retained, including a nonsense mutation in TNFRSF14 and missense mutations in IL4R and SOCS3. The TNFRSF14 mutation may contribute to the accumulation and activation of T follicular helper cells by disrupting the inhibitory HVEM–BTLA signaling pathway. In addition, IL4R and SOCS3 mutations may lead to upregulation of the IL-4/JAK/STAT6 pathway, promoting tumor cell survival and proliferation. These findings provide new insights into the molecular pathogenesis of FCL of the LFGT.
ArticleNumber	300805
Author	Kitaoka, Takumi Aizawa, Keiko Kitamura, Eiichi Abe, Madoka Sudo, Takeshi Uchiyama, Naoya Kabasawa, Takanobu Suzuki, Kazushi Ohe, Rintaro Satou, Akira
Author_xml	– sequence: 1 givenname: Takumi surname: Kitaoka fullname: Kitaoka, Takumi organization: Department of Pathology, Yonezawa City Hospital, Yonezawa, Japan – sequence: 2 givenname: Akira surname: Satou fullname: Satou, Akira organization: Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan – sequence: 3 givenname: Eiichi surname: Kitamura fullname: Kitamura, Eiichi organization: Department of Pathology, Yamagata University Faculty of Medicine, Yamagata, Japan – sequence: 4 givenname: Keiko surname: Aizawa fullname: Aizawa, Keiko organization: Department of Internal Medicine III, Division of Hematology and Cell Therapy, Yamagata University, Faculty of Medicine, Yamagata, Japan – sequence: 5 givenname: Takeshi surname: Sudo fullname: Sudo, Takeshi organization: Department of Obstetrics and Gynecology, Yonezawa City Hospital, Yonezawa, Japan – sequence: 6 givenname: Madoka surname: Abe fullname: Abe, Madoka organization: Department of Obstetrics and Gynecology, Yonezawa City Hospital, Yonezawa, Japan – sequence: 7 givenname: Takanobu surname: Kabasawa fullname: Kabasawa, Takanobu organization: Department of Pathology, Yamagata University Faculty of Medicine, Yamagata, Japan – sequence: 8 givenname: Kazushi surname: Suzuki fullname: Suzuki, Kazushi organization: Department of Pathology, Yamagata University Faculty of Medicine, Yamagata, Japan – sequence: 9 givenname: Naoya surname: Uchiyama fullname: Uchiyama, Naoya organization: Department of Pathology, Yamagata University Faculty of Medicine, Yamagata, Japan – sequence: 10 givenname: Rintaro surname: Ohe fullname: Ohe, Rintaro email: r-ooe@med.id.yamagata-u.ac.jp organization: Department of Pathology, Yamagata University Faculty of Medicine, Yamagata, Japan
BookMark	eNqFkduKFDEQhhtZwXXdB_AuL9AzOfZBQRgWD6MDXuwI3oVKunonbU_SpLO7zNubdkREUK8SKvV_lfr_58WFDx6L4iWjK0ZZtR5WhymuOOVqJShtqHpSXPK65mUtqq8Xv92fFdfzPFBKecNyI7ss_HZXyvXHzaf17X6zr8gE6fAIJwI2uQdILnjiPOnDODo7IrHoE0Yyno7TIRyBhJ6kA5IxPOZqj0fIPXfoXYKRpJghr8iGWJiRRJxCTC-Kpz2MM17_PK-KL-_e7m8-lLvP77c3m11pJatYKQ3SVra9BWNb2qiurqUyneFoDAgDXLaqV9CwyhiFrUTOlBFGQn7vG16Jq2J75nYBBj1Fd4R40gGc_lEI8U5DTMtKGhVrqKg6iz2XC7VijZStEF0LTLAms9iZZWOY54j9Lx6jevFfDzr7rxf_9dn_rHl91mBe8sFh1LN16C12LqJN-Rfun-o3f6jt6LyzMH7DE85DuI8-u6eZnrmm-nbJd4mXqxytqGUGtH8H_Gf4dz8ytrU
Cites_doi	10.1111/imr.12860 10.1038/modpathol.2016.51 10.3960/jslrt.24034 10.1038/s41375-022-01641-x 10.1182/blood-2016-02-698977 10.1080/10428194.2024.2381014 10.1182/blood-2017-09-808907 10.1182/bloodadvances.2020001665 10.1097/PAS.0000000000002003 10.1016/j.immuni.2019.05.022 10.1111/cas.13303 10.1182/bloodadvances.2022006985 10.1016/j.immuni.2019.04.011 10.1038/s41392-021-00791-1 10.1016/j.jmb.2009.01.024 10.1016/j.cellsig.2022.110331 10.1182/bloodadvances.2020002944 10.1002/jcp.30662 10.1016/j.humpath.2020.09.014 10.1093/nar/gky1016
ContentType	Journal Article
Copyright	2025 The Author(s) The Author(s)
Copyright_xml	– notice: 2025 The Author(s) – notice: The Author(s)
DBID	6I. AAFTH AAYXX CITATION DOA
DOI	10.1016/j.hpr.2025.300805
DatabaseName	ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef
DatabaseTitleList
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	2772-736X
EndPage	300805
ExternalDocumentID	oai_doaj_org_article_e518036dcef245f5a61844933d9a1318 10_1016_j_hpr_2025_300805 S2772736X25000374 1_s2_0_S2772736X25000374
GroupedDBID	.1- .FO 0R~ AALRI AAXUO AAYWO ACVFH ADCNI ADVLN AEUPX AFJKZ AFPUW AFRHN AIGII AITUG AJUYK AKBMS AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ APXCP EBS FDB GROUPED_DOAJ M41 M~E NQS OK1 ROL Z5R 6I. AAFTH AAYXX CITATION
ID	FETCH-LOGICAL-c4161-4be0949fcabc9085d7745bdb2ebba3ba2495f5a816bb5e94e215b3b4aebbf8263
IEDL.DBID	DOA
ISSN	2772-736X
IngestDate	Mon Nov 17 19:32:47 EST 2025 Thu Nov 27 01:05:32 EST 2025 Sat Nov 29 17:03:05 EST 2025 Sat Nov 29 12:11:23 EST 2025 Sat Nov 29 06:56:25 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Keywords	SOCS3 TNFRSF14 IL4R Whole-exome sequencing Follicle center lymphoma of the lower female genital tract
Language	English
License	This is an open access article under the CC BY-NC license.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c4161-4be0949fcabc9085d7745bdb2ebba3ba2495f5a816bb5e94e215b3b4aebbf8263
OpenAccessLink	https://doaj.org/article/e518036dcef245f5a61844933d9a1318
PageCount	1
ParticipantIDs	doaj_primary_oai_doaj_org_article_e518036dcef245f5a61844933d9a1318 crossref_primary_10_1016_j_hpr_2025_300805 elsevier_sciencedirect_doi_10_1016_j_hpr_2025_300805 elsevier_clinicalkeyesjournals_1_s2_0_S2772736X25000374 elsevier_clinicalkey_doi_10_1016_j_hpr_2025_300805
PublicationCentury	2000
PublicationDate	2025-11-01
PublicationDateYYYYMMDD	2025-11-01
PublicationDate_xml	– month: 11 year: 2025 text: 2025-11-01 day: 01
PublicationDecade	2020
PublicationTitle	Human Pathology Reports
PublicationYear	2025
Publisher	Elsevier Inc Elsevier
Publisher_xml	– name: Elsevier Inc – name: Elsevier
References	Hu, Ii, Fu, Zhao, Wang (b0070) 2021; 6 Mentz, Keay, Strobl, Antoniolli, Adolph, Heide (b0065) 2022; 36 Siddiqi, Friedman, Barry-Holson, Ma, Thodima, Kang (b0050) 2016; 29 Barasch, Liu, Ho, Bailey, Aggarwal, Cook (b0015) 2020; 106 Mintz, Felce, Chou, Mayya, Xu, Shui (b0030) 2019; 51 Wu, Wang, Franzen, Guo, Lee, Li (b0085) 2021; 5 Mintz, Cyster (b0025) 2020; 296 Babon, Sabo, Zhang, Nicola, Norton (b0060) 2009; 387 Leveille, Chan, Mirza, Kume, Müschen (b0080) 2022; 94 Kodgule, Chen, Khonde, Robinson, D’Albora, Cook (b0090) 2022; 6 Kogure, Kataoka (b0100) 2017; 108 Crotty (b0035) 2019; 50 Vallois, Dobay, Morin, Lemonnier, Missiaglia, Juilland (b0095) 2016; 128 Rentzsch, Witten, Cooper, Shendure, Kircher (b0020) 2019; 47 Viganò, Gunawardana, Mottok, Van Tol, Mak, Chan (b0055) 2018; 131 Nann, Ramis-Zaldivar, Müller, Gonzalez-Farre, Schmidt, Egan (b0075) 2020; 4 Saksena, Jain, Pack, Kim, Lee, Tyagi (b0005) 2023; 47 Ohe (b0045) 2024; 64 Santos Louro, Dimopoulos, Leventaki, Vega (b0010) 2024; 65 Abd El-Aleem, Saber, Aziz, El-Sherif, Abdelraof, Djouhri (b0040) 2022; 237 Leveille (10.1016/j.hpr.2025.300805_b0080) 2022; 94 Viganò (10.1016/j.hpr.2025.300805_b0055) 2018; 131 Mintz (10.1016/j.hpr.2025.300805_b0025) 2020; 296 Hu (10.1016/j.hpr.2025.300805_b0070) 2021; 6 Rentzsch (10.1016/j.hpr.2025.300805_b0020) 2019; 47 Babon (10.1016/j.hpr.2025.300805_b0060) 2009; 387 Kodgule (10.1016/j.hpr.2025.300805_b0090) 2022; 6 Mintz (10.1016/j.hpr.2025.300805_b0030) 2019; 51 Kogure (10.1016/j.hpr.2025.300805_b0100) 2017; 108 Santos Louro (10.1016/j.hpr.2025.300805_b0010) 2024; 65 Saksena (10.1016/j.hpr.2025.300805_b0005) 2023; 47 Siddiqi (10.1016/j.hpr.2025.300805_b0050) 2016; 29 Crotty (10.1016/j.hpr.2025.300805_b0035) 2019; 50 Wu (10.1016/j.hpr.2025.300805_b0085) 2021; 5 Barasch (10.1016/j.hpr.2025.300805_b0015) 2020; 106 Abd El-Aleem (10.1016/j.hpr.2025.300805_b0040) 2022; 237 Vallois (10.1016/j.hpr.2025.300805_b0095) 2016; 128 Mentz (10.1016/j.hpr.2025.300805_b0065) 2022; 36 Nann (10.1016/j.hpr.2025.300805_b0075) 2020; 4 Ohe (10.1016/j.hpr.2025.300805_b0045) 2024; 64
References_xml	– volume: 29 start-page: 570 year: 2016 end-page: 581 ident: b0050 article-title: Characterization of a variant of t(14;18) negative nodal diffuse follicular lymphoma with CD23 expression, 1p36/TNFRSF14 abnormalities, and STAT6 mutations publication-title: Mod. Pathol. – volume: 47 start-page: D886 year: 2019 end-page: D894 ident: b0020 article-title: CADD: predicting the deleteriousness of variants throughout the human genome publication-title: Nucleic Acids Res. – volume: 5 start-page: 185 year: 2021 end-page: 197 ident: b0085 article-title: Inhibition of B-cell receptor signaling disrupts cell adhesion in mantle cell lymphoma via RAC2 publication-title: Blood Adv. – volume: 387 start-page: 162 year: 2009 end-page: 174 ident: b0060 article-title: The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression publication-title: J. Mol. Biol. – volume: 106 start-page: 93 year: 2020 end-page: 105 ident: b0015 article-title: The molecular landscape and other distinctive features of primary cutaneous follicle center lymphoma publication-title: Hum. Pathol. – volume: 47 start-page: 409 year: 2023 end-page: 419 ident: b0005 article-title: Follicle center lymphoma (FCL) of the lower female genital tract (LFGT): a novel variant of primary cutaneous follicle center lymphoma (PCFCL) publication-title: Am. J. Surg. Pathol. – volume: 65 start-page: 1909 year: 2024 end-page: 1912 ident: b0010 article-title: Follicular lymphoma of the lower female genital tract: an indolent and localized extranodal follicular lymphoma with mutation of TNFRSF14 publication-title: Leuk. Lymphoma – volume: 4 start-page: 5652 year: 2020 end-page: 5665 ident: b0075 article-title: Follicular lymphoma t(14;18)-negative is genetically a heterogeneous disease publication-title: Blood Adv. – volume: 64 start-page: 166 year: 2024 end-page: 176 ident: b0045 article-title: Mechanisms of lymphoma-stromal interactions focusing on tumor-associated macrophages, fibroblastic reticular cells, and follicular dendritic cells publication-title: J. Clin. Exp. Hematop. – volume: 94 year: 2022 ident: b0080 article-title: SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies publication-title: Cell. Signal. – volume: 51 start-page: 310 year: 2019 end-page: 323.e317 ident: b0030 article-title: The HVEM-BTLA axis restrains T cell help to germinal center B cells and functions as a cell-extrinsic suppressor in lymphomagenesis publication-title: Immunity – volume: 50 start-page: 1132 year: 2019 end-page: 1148 ident: b0035 article-title: T follicular helper cell biology: a decade of discovery and diseases publication-title: Immunity – volume: 128 start-page: 1490 year: 2016 end-page: 1502 ident: b0095 article-title: Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell–derived lymphomas publication-title: Blood – volume: 6 start-page: 402 year: 2021 ident: b0070 article-title: The JAK/STAT signaling pathway: from bench to clinic publication-title: Signal Transduct. Target. Ther. – volume: 36 start-page: 2281 year: 2022 end-page: 2292 ident: b0065 article-title: PARP14 is a novel target in STAT6 mutant follicular lymphoma publication-title: Leukemia – volume: 6 start-page: 6051 year: 2022 end-page: 6055 ident: b0090 article-title: Recurrent switch 2 domain RAC2 mutations in intravascular large B-cell lymphoma publication-title: Blood Adv. – volume: 237 start-page: 2019 year: 2022 end-page: 2033 ident: b0040 article-title: Follicular dendritic cells publication-title: J. Cell. Physiol. – volume: 131 start-page: 2036 year: 2018 end-page: 2046 ident: b0055 article-title: Somatic IL4R mutations in primary mediastinal large B-cell lymphoma lead to constitutive JAK-STAT signaling activation publication-title: Blood – volume: 296 start-page: 48 year: 2020 end-page: 61 ident: b0025 article-title: T follicular helper cells in germinal center B cell selection and lymphomagenesis publication-title: Immunol. Rev. – volume: 108 start-page: 1719 year: 2017 end-page: 1725 ident: b0100 article-title: Genetic alterations in adult T-cell leukemia/lymphoma publication-title: Cancer Sci. – volume: 296 start-page: 48 issue: 1 year: 2020 ident: 10.1016/j.hpr.2025.300805_b0025 article-title: T follicular helper cells in germinal center B cell selection and lymphomagenesis publication-title: Immunol. Rev. doi: 10.1111/imr.12860 – volume: 29 start-page: 570 issue: 6 year: 2016 ident: 10.1016/j.hpr.2025.300805_b0050 article-title: Characterization of a variant of t(14;18) negative nodal diffuse follicular lymphoma with CD23 expression, 1p36/TNFRSF14 abnormalities, and STAT6 mutations publication-title: Mod. Pathol. doi: 10.1038/modpathol.2016.51 – volume: 64 start-page: 166 issue: 3 year: 2024 ident: 10.1016/j.hpr.2025.300805_b0045 article-title: Mechanisms of lymphoma-stromal interactions focusing on tumor-associated macrophages, fibroblastic reticular cells, and follicular dendritic cells publication-title: J. Clin. Exp. Hematop. doi: 10.3960/jslrt.24034 – volume: 36 start-page: 2281 issue: 9 year: 2022 ident: 10.1016/j.hpr.2025.300805_b0065 article-title: PARP14 is a novel target in STAT6 mutant follicular lymphoma publication-title: Leukemia doi: 10.1038/s41375-022-01641-x – volume: 128 start-page: 1490 issue: 11 year: 2016 ident: 10.1016/j.hpr.2025.300805_b0095 article-title: Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell–derived lymphomas publication-title: Blood doi: 10.1182/blood-2016-02-698977 – volume: 65 start-page: 1909 issue: 12 year: 2024 ident: 10.1016/j.hpr.2025.300805_b0010 article-title: Follicular lymphoma of the lower female genital tract: an indolent and localized extranodal follicular lymphoma with mutation of TNFRSF14 publication-title: Leuk. Lymphoma doi: 10.1080/10428194.2024.2381014 – volume: 131 start-page: 2036 issue: 18 year: 2018 ident: 10.1016/j.hpr.2025.300805_b0055 article-title: Somatic IL4R mutations in primary mediastinal large B-cell lymphoma lead to constitutive JAK-STAT signaling activation publication-title: Blood doi: 10.1182/blood-2017-09-808907 – volume: 5 start-page: 185 issue: 1 year: 2021 ident: 10.1016/j.hpr.2025.300805_b0085 article-title: Inhibition of B-cell receptor signaling disrupts cell adhesion in mantle cell lymphoma via RAC2 publication-title: Blood Adv. doi: 10.1182/bloodadvances.2020001665 – volume: 47 start-page: 409 issue: 3 year: 2023 ident: 10.1016/j.hpr.2025.300805_b0005 article-title: Follicle center lymphoma (FCL) of the lower female genital tract (LFGT): a novel variant of primary cutaneous follicle center lymphoma (PCFCL) publication-title: Am. J. Surg. Pathol. doi: 10.1097/PAS.0000000000002003 – volume: 51 start-page: 310 issue: 2 year: 2019 ident: 10.1016/j.hpr.2025.300805_b0030 article-title: The HVEM-BTLA axis restrains T cell help to germinal center B cells and functions as a cell-extrinsic suppressor in lymphomagenesis publication-title: Immunity doi: 10.1016/j.immuni.2019.05.022 – volume: 108 start-page: 1719 issue: 9 year: 2017 ident: 10.1016/j.hpr.2025.300805_b0100 article-title: Genetic alterations in adult T-cell leukemia/lymphoma publication-title: Cancer Sci. doi: 10.1111/cas.13303 – volume: 6 start-page: 6051 issue: 23 year: 2022 ident: 10.1016/j.hpr.2025.300805_b0090 article-title: Recurrent switch 2 domain RAC2 mutations in intravascular large B-cell lymphoma publication-title: Blood Adv. doi: 10.1182/bloodadvances.2022006985 – volume: 50 start-page: 1132 issue: 5 year: 2019 ident: 10.1016/j.hpr.2025.300805_b0035 article-title: T follicular helper cell biology: a decade of discovery and diseases publication-title: Immunity doi: 10.1016/j.immuni.2019.04.011 – volume: 6 start-page: 402 issue: 1 year: 2021 ident: 10.1016/j.hpr.2025.300805_b0070 article-title: The JAK/STAT signaling pathway: from bench to clinic publication-title: Signal Transduct. Target. Ther. doi: 10.1038/s41392-021-00791-1 – volume: 387 start-page: 162 issue: 1 year: 2009 ident: 10.1016/j.hpr.2025.300805_b0060 article-title: The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2009.01.024 – volume: 94 year: 2022 ident: 10.1016/j.hpr.2025.300805_b0080 article-title: SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies publication-title: Cell. Signal. doi: 10.1016/j.cellsig.2022.110331 – volume: 4 start-page: 5652 issue: 22 year: 2020 ident: 10.1016/j.hpr.2025.300805_b0075 article-title: Follicular lymphoma t(14;18)-negative is genetically a heterogeneous disease publication-title: Blood Adv. doi: 10.1182/bloodadvances.2020002944 – volume: 237 start-page: 2019 issue: 4 year: 2022 ident: 10.1016/j.hpr.2025.300805_b0040 article-title: Follicular dendritic cells publication-title: J. Cell. Physiol. doi: 10.1002/jcp.30662 – volume: 106 start-page: 93 year: 2020 ident: 10.1016/j.hpr.2025.300805_b0015 article-title: The molecular landscape and other distinctive features of primary cutaneous follicle center lymphoma publication-title: Hum. Pathol. doi: 10.1016/j.humpath.2020.09.014 – volume: 47 start-page: D886 issue: D1 year: 2019 ident: 10.1016/j.hpr.2025.300805_b0020 article-title: CADD: predicting the deleteriousness of variants throughout the human genome publication-title: Nucleic Acids Res. doi: 10.1093/nar/gky1016
SSID	ssj0002810081
Score	2.308547
Snippet	Follicle center lymphoma (FCL) of the lower female genital tract (LFGT) is a recently proposed subtype of B-cell lymphoma that resembles primary cutaneous... AbstractFollicle center lymphoma (FCL) of the lower female genital tract (LFGT) is a recently proposed subtype of B-cell lymphoma that resembles primary...
SourceID	doaj crossref elsevier
SourceType	Open Website Index Database Publisher
StartPage	300805
SubjectTerms	Follicle center lymphoma of the lower female genital tract IL4R Pathology SOCS3 TNFRSF14 Whole-exome sequencing
Title	IL-4/JAK/STAT6 pathway activation in follicle center lymphoma of the lower female genital tract: A case report
URI	https://www.clinicalkey.com/#!/content/1-s2.0-S2772736X25000374 https://www.clinicalkey.es/playcontent/1-s2.0-S2772736X25000374 https://dx.doi.org/10.1016/j.hpr.2025.300805 https://doaj.org/article/e518036dcef245f5a61844933d9a1318
Volume	42
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2772-736X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0002810081 issn: 2772-736X databaseCode: DOA dateStart: 20210101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2772-736X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0002810081 issn: 2772-736X databaseCode: M~E dateStart: 20210101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT9tAEF5VCFVcKvpABGg1B06V3OD1rmNzC4ioQECVSKXcVvsUQeCgJIC48NuZ8doolRBcevHB9q7tmfXON7sz8zG2G3RWEi13kjmXJyI3PNGGo7Oi89y40luha9aSYe_8vBiPyz9LVF8UExbLA0fBdb1MC5xlnfWBCxmkJoYSgW64K3WKA5JmX0Q9S87UVb1kREVr0nYbsw7ouryl-p9c_soIJsl_DFFdr3_JHi3ZmME6-9SAQ-jHl_rMPvjqC_t41mx_f2XV8TAR3ZP-afdi1B_lQHTCD_oRKDkhLq3CpIJAdbaxPVDgpZ_B9SNqbHqjYRoA4R5cEzEaBH-DtgFw_BBtCCwoW2of-mDRrEHcSfjG_g6ORoe_k4YwIbHkpyTCePTWymC1sSViKYfYThpnuDdGZ0YTzzRKsEhzY6QvhUd7bzIjNF4P6GdkG2ylmlZ-k0Gx5yzXqbbcB1RXXpShcNIXQqPocX7vsJ-t9NRtrIuh2oCxK4WiViRqFUXdYQck35cbqaR1fQIVrRpFq_cU3WG81Y5qs0ZxnsOOJm89ufdaIz9v_tS5StWcqz11wXuE5PIxl7EmT4eJl5YNGIkg4-0Hbv2PT91ma9RlTHncYSuL2Z3_zlbt_WIyn_2oRzoez56OngHDsQHQ
linkProvider	Directory of Open Access Journals
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=IL-4%2FJAK%2FSTAT6+pathway+activation+in+follicle+center+lymphoma+of+the+lower+female+genital+tract%3A+A+case+report&rft.jtitle=Human+Pathology+Reports&rft.au=Kitaoka%2C+Takumi&rft.au=Satou%2C+Akira&rft.au=Kitamura%2C+Eiichi&rft.au=Aizawa%2C+Keiko&rft.date=2025-11-01&rft.pub=Elsevier+Inc&rft.issn=2772-736X&rft.eissn=2772-736X&rft.volume=42&rft_id=info:doi/10.1016%2Fj.hpr.2025.300805&rft.externalDocID=S2772736X25000374
thumbnail_m	http://cvtisr.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F2772736X%2Fcov200h.gif