Is aging a barrier to reprogramming? Lessons from induced pluripotent stem cells

The discovery of induced pluripotent stem cells (iPSCs) has the potential to revolutionize the field of regenerative medicine. In the past few years, iPSCs have been the subject of intensive research towards their application in disease modeling and drug screening. In the future, these cells may be...

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Vydáno v:	Biogerontology (Dordrecht) Ročník 14; číslo 6; s. 591 - 602
Hlavní autoři:	Phanthong, Phetcharat, Raveh-Amit, Hadas, Li, Tong, Kitiyanant, Yindee, Dinnyes, Andras
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Dordrecht Springer Netherlands 01.12.2013 Springer Nature B.V
Témata:	Age Factors Aging Aging - genetics Aging - metabolism Aging - pathology Aging, Premature - genetics Aging, Premature - metabolism Aging, Premature - pathology Aging, Premature - physiopathology Aging, Premature - therapy Anatomical systems Animals Biomedical and Life Sciences Cell Biology Cellular Reprogramming Cellular Senescence Deoxyribonucleic acid Developmental Biology DNA Gene Expression Regulation, Developmental Genetic Therapy - methods Genomes Genomics Geriatrics/Gerontology Humans Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - pathology Life Sciences Medical screening Medicine Nuclear Transfer Techniques Regenerative medicine Regenerative Medicine - methods Research applications Review Article Senescence Stem cells Telomerase Tumors Hungary Thailand Aging Premature aging Nuclear reprogramming Induced pluripotent stem cells Cellular senescence
ISSN:	1389-5729, 1573-6768, 1573-6768
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Abstract	The discovery of induced pluripotent stem cells (iPSCs) has the potential to revolutionize the field of regenerative medicine. In the past few years, iPSCs have been the subject of intensive research towards their application in disease modeling and drug screening. In the future, these cells may be applied in cell therapy to replace or regenerate tissues by autologous transplantation. However, two major hurdles need to be resolved in order to reach the later goal: the low reprogramming efficiency and the safety risks, such as the integration of foreign DNA into the genome of the cells and the tumor formation potential arising from transplantation of residual undifferentiated cells. Recently, aging emerged as one of the barriers that accounts, at least in part, for the low reprogramming efficiency of bona fide iPSCs. Here, we review the molecular pathways linking aging and reprogramming along with the unanswered questions in the field. We discuss whether reprogramming rejuvenates the molecular and cellular features associated with age, and present the recent advances with iPSC-based models, contributing to our understanding of physiological and premature aging.
AbstractList	The discovery of induced pluripotent stem cells (iPSCs) has the potential to revolutionize the field of regenerative medicine. In the past few years, iPSCs have been the subject of intensive research towards their application in disease modeling and drug screening. In the future, these cells may be applied in cell therapy to replace or regenerate tissues by autologous transplantation. However, two major hurdles need to be resolved in order to reach the later goal: the low reprogramming efficiency and the safety risks, such as the integration of foreign DNA into the genome of the cells and the tumor formation potential arising from transplantation of residual undifferentiated cells. Recently, aging emerged as one of the barriers that accounts, at least in part, for the low reprogramming efficiency of bona fide iPSCs. Here, we review the molecular pathways linking aging and reprogramming along with the unanswered questions in the field. We discuss whether reprogramming rejuvenates the molecular and cellular features associated with age, and present the recent advances with iPSC-based models, contributing to our understanding of physiological and premature aging. The discovery of induced pluripotent stem cells (iPSCs) has the potential to revolutionize the field of regenerative medicine. In the past few years, iPSCs have been the subject of intensive research towards their application in disease modeling and drug screening. In the future, these cells may be applied in cell therapy to replace or regenerate tissues by autologous transplantation. However, two major hurdles need to be resolved in order to reach the later goal: the low reprogramming efficiency and the safety risks, such as the integration of foreign DNA into the genome of the cells and the tumor formation potential arising from transplantation of residual undifferentiated cells. Recently, aging emerged as one of the barriers that accounts, at least in part, for the low reprogramming efficiency of bona fide iPSCs. Here, we review the molecular pathways linking aging and reprogramming along with the unanswered questions in the field. We discuss whether reprogramming rejuvenates the molecular and cellular features associated with age, and present the recent advances with iPSC-based models, contributing to our understanding of physiological and premature aging. The discovery of induced pluripotent stem cells (iPSCs) has the potential to revolutionize the field of regenerative medicine. In the past few years, iPSCs have been the subject of intensive research towards their application in disease modeling and drug screening. In the future, these cells may be applied in cell therapy to replace or regenerate tissues by autologous transplantation. However, two major hurdles need to be resolved in order to reach the later goal: the low reprogramming efficiency and the safety risks, such as the integration of foreign DNA into the genome of the cells and the tumor formation potential arising from transplantation of residual undifferentiated cells. Recently, aging emerged as one of the barriers that accounts, at least in part, for the low reprogramming efficiency of bona fide iPSCs. Here, we review the molecular pathways linking aging and reprogramming along with the unanswered questions in the field. We discuss whether reprogramming rejuvenates the molecular and cellular features associated with age, and present the recent advances with iPSC-based models, contributing to our understanding of physiological and premature aging.The discovery of induced pluripotent stem cells (iPSCs) has the potential to revolutionize the field of regenerative medicine. In the past few years, iPSCs have been the subject of intensive research towards their application in disease modeling and drug screening. In the future, these cells may be applied in cell therapy to replace or regenerate tissues by autologous transplantation. However, two major hurdles need to be resolved in order to reach the later goal: the low reprogramming efficiency and the safety risks, such as the integration of foreign DNA into the genome of the cells and the tumor formation potential arising from transplantation of residual undifferentiated cells. Recently, aging emerged as one of the barriers that accounts, at least in part, for the low reprogramming efficiency of bona fide iPSCs. Here, we review the molecular pathways linking aging and reprogramming along with the unanswered questions in the field. We discuss whether reprogramming rejuvenates the molecular and cellular features associated with age, and present the recent advances with iPSC-based models, contributing to our understanding of physiological and premature aging.
Author	Phanthong, Phetcharat Li, Tong Kitiyanant, Yindee Dinnyes, Andras Raveh-Amit, Hadas
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CitedBy_id	crossref_primary_10_1016_j_molmed_2016_05_010 crossref_primary_10_59368_agingbio_20250039 crossref_primary_10_1016_j_expneurol_2024_114753 crossref_primary_10_3389_fncel_2014_00347 crossref_primary_10_1002_stem_2899 crossref_primary_10_1016_j_exger_2017_01_008 crossref_primary_10_1155_2014_756240 crossref_primary_10_3389_fcell_2023_1194070
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Snippet	The discovery of induced pluripotent stem cells (iPSCs) has the potential to revolutionize the field of regenerative medicine. In the past few years, iPSCs...
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SubjectTerms	Age Factors Aging Aging - genetics Aging - metabolism Aging - pathology Aging, Premature - genetics Aging, Premature - metabolism Aging, Premature - pathology Aging, Premature - physiopathology Aging, Premature - therapy Anatomical systems Animals Biomedical and Life Sciences Cell Biology Cellular Reprogramming Cellular Senescence Deoxyribonucleic acid Developmental Biology DNA Gene Expression Regulation, Developmental Genetic Therapy - methods Genomes Genomics Geriatrics/Gerontology Humans Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - pathology Life Sciences Medical screening Medicine Nuclear Transfer Techniques Regenerative medicine Regenerative Medicine - methods Research applications Review Article Senescence Stem cells Telomerase Tumors
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Title	Is aging a barrier to reprogramming? Lessons from induced pluripotent stem cells
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