Robust Optimal Design for the Estimation of Hyperparameters in Population Pharmacokinetics

The expectation of the determinant of the inverse of the population Fisher information matrix is proposed as a criterion to evaluate and optimize designs for the estimation of population pharmacokinetic (PK) parameters. Given a PK model, a measurement error model, a parametric distribution of the pa...

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Bibliographic Details
Published in:	Journal of pharmacokinetics and biopharmaceutics Vol. 26; no. 6; pp. 689 - 716
Main Authors:	Tod, Michel, Mentré, France, Merlé, Yann, Mallet, Alain
Format:	Journal Article
Language:	English
Published:	New York, NY Plenum 01.12.1998 Springer Nature B.V
Subjects:	Biological and medical sciences General pharmacology Humans Medical sciences Models, Biological Pharmacokinetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Population Surveillance Studies Human Optimal sampling Compartmental model Methodology Simulation Experimental design Estimation Population Kinetic parameter Pharmacokinetics Optimization Sampling frequency
ISSN:	0090-466X, 1567-567X, 1573-8744
Online Access:	Get full text
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