Lipid droplets in the nervous system

Lipid droplets are dynamic intracellular lipid storage organelles that respond to the physiological state of cells. In addition to controlling cell metabolism, they play a protective role for many cellular stressors, including oxidative stress. Despite prior descriptions of lipid droplets appearing...

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Veröffentlicht in:The Journal of cell biology Jg. 220; H. 7
Hauptverfasser: Ralhan, Isha, Chang, Chi-Lun, Lippincott-Schwartz, Jennifer, Ioannou, Maria S
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 05.07.2021
Schlagworte:
Aging - genetics
Aging - metabolism
Animals
Humans
Lipid Droplets - metabolism
Lipid Metabolism - genetics
Nervous System - metabolism
Oxidative Stress - genetics
ISSN:1540-8140, 1540-8140
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Zusammenfassung:Lipid droplets are dynamic intracellular lipid storage organelles that respond to the physiological state of cells. In addition to controlling cell metabolism, they play a protective role for many cellular stressors, including oxidative stress. Despite prior descriptions of lipid droplets appearing in the brain as early as a century ago, only recently has the role of lipid droplets in cells found in the brain begun to be understood. Lipid droplet functions have now been described for cells of the nervous system in the context of development, aging, and an increasing number of neuropathologies. Here, we review the basic mechanisms of lipid droplet formation, turnover, and function and discuss how these mechanisms enable lipid droplets to function in different cell types of the nervous system under healthy and pathological conditions.
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ISSN:1540-8140
1540-8140
DOI:10.1083/jcb.202102136