Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers

The alternative lengthening of telomeres (ALT) pathway is a telomerase-independent mechanism for immortalization in cancer cells and is commonly activated in low-grade and high-grade glioma, as well as osteosarcoma. The ALT pathway can be activated under various conditions and has often been shown t...

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Bibliographic Details
Published in:	Nucleic acids research Vol. 53; no. 4
Main Authors:	Goncalves, Tomas, Cunniffe, Siobhan, Ma, Tiffany S, Mattis, Natalie, Rose, Andrew W, Kent, Thomas, Mole, David R, Geiller, Helene E B, van Bijsterveldt, Linda, Humphrey, Timothy C, Hammond, Ester M, Gibbons, Richard J, Clynes, David, Rose, Anna M
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 08.02.2025
Subjects:	Cell Line, Tumor Glioma - genetics Glioma - metabolism Glioma - pathology Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Humans Molecular and Structural Biology Mutation R-Loop Structures Reactive Oxygen Species - metabolism Telomere - genetics Telomere - metabolism Telomere Homeostasis - genetics Tumor Microenvironment - genetics X-linked Nuclear Protein - deficiency X-linked Nuclear Protein - genetics
ISSN:	0305-1048, 1362-4962, 1362-4962
Online Access:	Get full text
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