Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis

Progressive accrual of senescent cells in aging and chronic diseases is associated with detrimental effects in tissue homeostasis. We found that senescent fibroblasts and epithelia were not only refractory to macrophage-mediated engulfment and removal, but they also paralyzed the ability of macropha...

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Bibliographic Details

Published in:	The Journal of cell biology Vol. 222; no. 2
Main Authors:	Schloesser, Daniela, Lindenthal, Laura, Sauer, Julia, Chung, Kyoung-Jin, Chavakis, Triantafyllos, Griesser, Eva, Baskaran, Praveen, Maier-Habelsberger, Ulrike, Fundel-Clemens, Katrin, Schlotthauer, Ines, Watson, Carolin Kirsten, Swee, Lee Kim, Igney, Frederik, Park, John Edward, Huber-Lang, Markus S, Thomas, Matthew-James, El Kasmi, Karim Christian, Murray, Peter J
Format:	Journal Article
Language:	English
Published:	United States 06.02.2023
Subjects:	Aminoacyltransferases - metabolism Animals Apoptosis CD24 Antigen - metabolism CD47 Antigen - genetics CD47 Antigen - metabolism Humans Macrophages - cytology Mice Senescence-Associated Secretory Phenotype Up-Regulation
ISSN:	1540-8140, 1540-8140
Online Access:	Get more information
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