Paclitaxel in the Treatment of Carcinosarcoma of the Uterus: A Gynecologic Oncology Group Study

Objective. The goal of this study was to estimate the clinical activity of paclitaxel in patients with persistent or recurrent carcinosarcoma of the uterus who have failed other treatments. Methods. The Gynecologic Oncology Group (GOG) conducted a phase II study of paclitaxel 170 mg/m2 (135 mg/m2 in...

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Published in:	Gynecologic oncology Vol. 83; no. 2; pp. 268 - 270
Main Authors:	Curtin, John P., Blessing, John A., Soper, John T., DeGeest, Koen
Format:	Journal Article
Language:	English
Published:	San Diego, CA Elsevier Inc 01.11.2001 Elsevier
Subjects:	Adult Aged Antineoplastic Agents, Phytogenic - adverse effects Antineoplastic Agents, Phytogenic - therapeutic use Biological and medical sciences Carcinosarcoma - drug therapy Drug Administration Schedule Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Infusions, Intravenous Medical sciences Middle Aged Neoplasm Recurrence, Local - drug therapy Paclitaxel - adverse effects Paclitaxel - therapeutic use Tumors Uterine Neoplasms - drug therapy Human Antineoplastic agent Relapse Treatment resistance Treatment efficiency Malignant tumor Female genital diseases Chemotherapy Treatment Uterus Taxane derivatives Paclitaxel Uterine diseases Adult Female Spindle cell carcinoma
ISSN:	0090-8258, 1095-6859
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Abstract	Objective. The goal of this study was to estimate the clinical activity of paclitaxel in patients with persistent or recurrent carcinosarcoma of the uterus who have failed other treatments. Methods. The Gynecologic Oncology Group (GOG) conducted a phase II study of paclitaxel 170 mg/m2 (135 mg/m2 in those with prior irradiation) intravenously every 3 weeks in patients with histologic confirmation of carcinoma and measurable disease who had failed appropriate local therapy. Results. A total of 53 patients were entered into the study between September 1994 and January 1997; 44 patients were evaluable for response. The median age of the patients treated was 65 years (range: 38–79). Twenty-six patients had heterologous mixed mesodermal tumors (MMTs) and 18 patients had homologous tumors. A median of three courses were administered (range: 1–18). Fifteen patients had previous radiation therapy and 33 patients had failed prior chemotherapy. Eight patients (18.2%) had a response to paclitaxel: four patients had a complete response and four had a partial response. Neutropenia was the most common toxic effect. Conclusions. Paclitaxel had moderate activity in patients with carcinosarcoma of the uterus. The GOG is currently studying the combination of paclitaxel and ifosfamide versus ifosfamide alone for patients with advanced or recurrent carcinosarcoma of the uterus.
AbstractList	The goal of this study was to estimate the clinical activity of paclitaxel in patients with persistent or recurrent carcinosarcoma of the uterus who have failed other treatments. The Gynecologic Oncology Group (GOG) conducted a phase II study of paclitaxel 170 mg/m(2) (135 mg/m(2) in those with prior irradiation) intravenously every 3 weeks in patients with histologic confirmation of carcinoma and measurable disease who had failed appropriate local therapy. A total of 53 patients were entered into the study between September 1994 and January 1997; 44 patients were evaluable for response. The median age of the patients treated was 65 years (range: 38-79). Twenty-six patients had heterologous mixed mesodermal tumors (MMTs) and 18 patients had homologous tumors. A median of three courses were administered (range: 1-18). Fifteen patients had previous radiation therapy and 33 patients had failed prior chemotherapy. Eight patients (18.2%) had a response to paclitaxel: four patients had a complete response and four had a partial response. Neutropenia was the most common toxic effect. Paclitaxel had moderate activity in patients with carcinosarcoma of the uterus. The GOG is currently studying the combination of paclitaxel and ifosfamide versus ifosfamide alone for patients with advanced or recurrent carcinosarcoma of the uterus. The goal of this study was to estimate the clinical activity of paclitaxel in patients with persistent or recurrent carcinosarcoma of the uterus who have failed other treatments.OBJECTIVEThe goal of this study was to estimate the clinical activity of paclitaxel in patients with persistent or recurrent carcinosarcoma of the uterus who have failed other treatments.The Gynecologic Oncology Group (GOG) conducted a phase II study of paclitaxel 170 mg/m(2) (135 mg/m(2) in those with prior irradiation) intravenously every 3 weeks in patients with histologic confirmation of carcinoma and measurable disease who had failed appropriate local therapy.METHODSThe Gynecologic Oncology Group (GOG) conducted a phase II study of paclitaxel 170 mg/m(2) (135 mg/m(2) in those with prior irradiation) intravenously every 3 weeks in patients with histologic confirmation of carcinoma and measurable disease who had failed appropriate local therapy.A total of 53 patients were entered into the study between September 1994 and January 1997; 44 patients were evaluable for response. The median age of the patients treated was 65 years (range: 38-79). Twenty-six patients had heterologous mixed mesodermal tumors (MMTs) and 18 patients had homologous tumors. A median of three courses were administered (range: 1-18). Fifteen patients had previous radiation therapy and 33 patients had failed prior chemotherapy. Eight patients (18.2%) had a response to paclitaxel: four patients had a complete response and four had a partial response. Neutropenia was the most common toxic effect.RESULTSA total of 53 patients were entered into the study between September 1994 and January 1997; 44 patients were evaluable for response. The median age of the patients treated was 65 years (range: 38-79). Twenty-six patients had heterologous mixed mesodermal tumors (MMTs) and 18 patients had homologous tumors. A median of three courses were administered (range: 1-18). Fifteen patients had previous radiation therapy and 33 patients had failed prior chemotherapy. Eight patients (18.2%) had a response to paclitaxel: four patients had a complete response and four had a partial response. Neutropenia was the most common toxic effect.Paclitaxel had moderate activity in patients with carcinosarcoma of the uterus. The GOG is currently studying the combination of paclitaxel and ifosfamide versus ifosfamide alone for patients with advanced or recurrent carcinosarcoma of the uterus.CONCLUSIONSPaclitaxel had moderate activity in patients with carcinosarcoma of the uterus. The GOG is currently studying the combination of paclitaxel and ifosfamide versus ifosfamide alone for patients with advanced or recurrent carcinosarcoma of the uterus. Objective. The goal of this study was to estimate the clinical activity of paclitaxel in patients with persistent or recurrent carcinosarcoma of the uterus who have failed other treatments. Methods. The Gynecologic Oncology Group (GOG) conducted a phase II study of paclitaxel 170 mg/m2 (135 mg/m2 in those with prior irradiation) intravenously every 3 weeks in patients with histologic confirmation of carcinoma and measurable disease who had failed appropriate local therapy. Results. A total of 53 patients were entered into the study between September 1994 and January 1997; 44 patients were evaluable for response. The median age of the patients treated was 65 years (range: 38–79). Twenty-six patients had heterologous mixed mesodermal tumors (MMTs) and 18 patients had homologous tumors. A median of three courses were administered (range: 1–18). Fifteen patients had previous radiation therapy and 33 patients had failed prior chemotherapy. Eight patients (18.2%) had a response to paclitaxel: four patients had a complete response and four had a partial response. Neutropenia was the most common toxic effect. Conclusions. Paclitaxel had moderate activity in patients with carcinosarcoma of the uterus. The GOG is currently studying the combination of paclitaxel and ifosfamide versus ifosfamide alone for patients with advanced or recurrent carcinosarcoma of the uterus.
Author	DeGeest, Koen Soper, John T. Blessing, John A. Curtin, John P.
Author_xml	– sequence: 1 givenname: John P. surname: Curtin fullname: Curtin, John P. organization: Department of Obstetrics and Gynecology, Cornell University Medical Center, Memorial Sloan–Kettering Cancer Center, New York, New York, 10021 – sequence: 2 givenname: John A. surname: Blessing fullname: Blessing, John A. organization: Gynecologic Oncology Group, Roswell Park Cancer Institute, Buffalo, New York, 14263 – sequence: 3 givenname: John T. surname: Soper fullname: Soper, John T. organization: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, 27710 – sequence: 4 givenname: Koen surname: DeGeest fullname: DeGeest, Koen organization: Department of Obstetrics and Gynecology, Rush Medical College, Chicago, Illinois, 60612
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SubjectTerms	Adult Aged Antineoplastic Agents, Phytogenic - adverse effects Antineoplastic Agents, Phytogenic - therapeutic use Biological and medical sciences Carcinosarcoma - drug therapy Drug Administration Schedule Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Infusions, Intravenous Medical sciences Middle Aged Neoplasm Recurrence, Local - drug therapy Paclitaxel - adverse effects Paclitaxel - therapeutic use Tumors Uterine Neoplasms - drug therapy
Title	Paclitaxel in the Treatment of Carcinosarcoma of the Uterus: A Gynecologic Oncology Group Study
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Volume	83
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