Localized Treatment with a Novel FDA-Approved Proteasome Inhibitor Blocks the Degradation of Dystrophin and Dystrophin-Associated Proteins in mdx Mice

Duchenne Muscular Dystrophy (DMD) is an incurable inherited disease ofchildhood, characterized by progressive muscle degeneration and weakness. Our previousfindings supported the idea that dystrophin and associated proteins, absent or greatlyreduced in DMD, are degraded in dystrophin-deficient muscl...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Cell cycle (Georgetown, Tex.) Ročník 6; číslo 10; s. 1242 - 1248
Hlavní autoři:	Bonuccelli, Gloria, Sotgia, Federica, Capozza, Franco, Gazzerro, Elisabetta, Minetti, Carlo, Lisanti, Michael P.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Taylor & Francis 15.05.2007
Témata:	Animals Binding Biology Bioscience Boronic Acids - pharmacology Bortezomib Calcium Cancer Cell Cycle Dipeptides - pharmacology Dystrophin - metabolism Dystrophin-Associated Proteins - metabolism Landes Male Mice Mice, Inbred mdx Microscopy, Fluorescence Muscle, Skeletal - metabolism Muscular Dystrophy, Duchenne - drug therapy Muscular Dystrophy, Duchenne - metabolism NF-kappa B - metabolism Organogenesis Protease Inhibitors - pharmacology Proteins Pyrazines - pharmacology
ISSN:	1538-4101, 1551-4005, 1551-4005
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!