A Plasma Circular RNA Profile Differentiates Subjects with Alzheimer’s Disease and Mild Cognitive Impairment from Healthy Controls

The most frequently used biomarkers to support the diagnosis of Alzheimer’s Disease (AD) are Aβ42, total-Tau, and phospho-tau protein levels in CSF. Moreover, magnetic resonance imaging is used to assess hippocampal atrophy, 18F-FDG PET to identify abnormal brain metabolism, and PET imaging for amyl...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 23; no. 21; p. 13232
Main Authors:	Piscopo, Paola, Manzini, Valeria, Rivabene, Roberto, Crestini, Alessio, Le Pera, Loredana, Pizzi, Elisabetta, Veroni, Caterina, Talarico, Giuseppina, Peconi, Martina, Castellano, Anna Elisa, D’Alessio, Carmelo, Bruno, Giuseppe, Corbo, Massimo, Vanacore, Nicola, Lacorte, Eleonora
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 31.10.2022 MDPI
Subjects:	Accuracy Age Alzheimer Disease - diagnosis Alzheimer Disease - genetics Alzheimer's disease Biomarkers Cluster analysis Cognitive Dysfunction - diagnosis Cognitive Dysfunction - genetics Gene loci Humans MicroRNAs MicroRNAs - genetics Pilot Projects Plasma Population RNA - genetics RNA polymerase RNA, Circular - blood RNA, Circular - genetics RNA, Untranslated Statistical significance Validation studies MCI AD circRNA biomarkers circular RNA microarray Real-Time PCR mild cognitive impairment Alzheimer Disease
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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