Computational methods for discovering structural variation with next-generation sequencing

In the last several years, a number of studies have described large-scale structural variation in several genomes. Traditionally, such methods have used whole-genome array comparative genome hybridization or single-nucleotide polymorphism arrays to detect large regions subject to copy-number variati...

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Vydáno v:	Nature methods Ročník 6; číslo Suppl 11; s. S13 - S20
Hlavní autoři:	Medvedev, Paul, Stanciu, Monica, Brudno, Michael
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Nature Publishing Group US 01.11.2009 Nature Publishing Group
Témata:	Algorithms Analysis Base Sequence Bioinformatics Biological Microscopy Biological Techniques Biomedical and Life Sciences Biomedical Engineering/Biotechnology Computational biology Computational Biology - methods DNA sequencing Genetic Variation Genome Genomes Genomics Genomics - methods Humans Hybridization Innovations Life Sciences Methods Molecular structure Nucleotide sequencing Properties Proteomics Research methodology review-article Sequence Analysis, DNA - methods Technological change Canada
ISSN:	1548-7091, 1548-7105, 1548-7105
On-line přístup:	Získat plný text
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