Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development

FOXL2 mutations cause gonadal dysgenesis or premature ovarian failure (POF) in women, as well as eyelid/forehead dysmorphology in both sexes (the 'blepharophimosis-ptosis-epicanthus inversus syndrome', BPES). Here we report that mice lacking Foxl2 recapitulate relevant features of human BP...

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Vydané v:	Human molecular genetics Ročník 13; číslo 11; s. 1171
Hlavní autori:	Uda, Manuela, Ottolenghi, Chris, Crisponi, Laura, Garcia, Jose Elias, Deiana, Manila, Kimber, Wendy, Forabosco, Antonino, Cao, Antonio, Schlessinger, David, Pilia, Giuseppe
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 01.06.2004
Predmet:	Animals Blepharophimosis - etiology Blepharophimosis - genetics Disease Models, Animal DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Embryo, Mammalian - pathology Eyelids - abnormalities Female Forkhead Box Protein L2 Forkhead Transcription Factors Gene Deletion Immunochemistry Ki-67 Antigen - immunology Male Mice Mice, Knockout Ovary - embryology Ovary - growth & development Ovary - pathology Primary Ovarian Insufficiency - etiology Primary Ovarian Insufficiency - genetics Primary Ovarian Insufficiency - pathology Syndrome Transcription Factors - genetics Transcription Factors - physiology
ISSN:	0964-6906
On-line prístup:	Zistit podrobnosti o prístupe
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