Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants

Local anesthetics, antiarrhythmics, and anticonvulsants include both charged and electroneutral compounds that block voltage-gated sodium channels. Prior studies have revealed a common drug-binding region within the pore, but details about the binding sites and mechanism of block remain unclear. Her...

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Vydáno v:	The Journal of general physiology Ročník 149; číslo 4; s. 465
Hlavní autoři:	Tikhonov, Denis B, Zhorov, Boris S
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 03.04.2017
Témata:	Acetamides - pharmacology Anesthetics, Local - pharmacology Animals Anti-Arrhythmia Agents - pharmacology Anticonvulsants - pharmacology Benzhydryl Compounds - pharmacology Binding Sites Carbamazepine - pharmacology Cocaine - pharmacology Humans Lacosamide Lamotrigine Lidocaine - analogs & derivatives Lidocaine - pharmacology Molecular Docking Simulation NAV1.4 Voltage-Gated Sodium Channel - chemistry NAV1.4 Voltage-Gated Sodium Channel - metabolism Phenols - pharmacology Phenytoin - pharmacology Piperazines - pharmacology Protein Binding Pyrimidines - pharmacology Quinidine - pharmacology Sodium Channel Blockers - pharmacology Triazines - pharmacology
ISSN:	1540-7748, 1540-7748
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