Oxidative stress biomarkers and asthma characteristics in adults of the EGEA study

Asthma is an oxidative stress related disease, but associations with asthma outcomes are poorly studied in adults. We aimed to study the associations between several biomarkers related to oxidative stress and various asthma outcomes.Cross-sectional analyses were conducted in 1388 adults (mean age 43...

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Veröffentlicht in:The European respiratory journal Jg. 50; H. 6
Hauptverfasser: Andrianjafimasy, Miora, Zerimech, Farid, Akiki, Zeina, Huyvaert, Helene, Le Moual, Nicole, Siroux, Valérie, Matran, Régis, Dumas, Orianne, Nadif, Rachel
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England 01.12.2017
Schlagworte:
Adult
Age of Onset
Asthma - blood
Asthma - physiopathology
Biomarkers
Breath Tests
Cohort Studies
Cross-Sectional Studies
Dinoprost - analogs & derivatives
Dinoprost - analysis
Exhalation
Female
Forced Expiratory Volume
Humans
Male
Middle Aged
Nitric Oxide - analysis
Oxidative Stress
Oxygen - chemistry
Regression Analysis
ISSN:1399-3003, 1399-3003
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Abstract Asthma is an oxidative stress related disease, but associations with asthma outcomes are poorly studied in adults. We aimed to study the associations between several biomarkers related to oxidative stress and various asthma outcomes.Cross-sectional analyses were conducted in 1388 adults (mean age 43 years, 44% with asthma) from the Epidemiological Study of the Genetics and Environment of Asthma (EGEA2). Three blood antioxidant enzyme activities (biomarkers of response to oxidative stress) and exhaled breath condensate 8-isoprostanes and plasma fluorescent oxidation products (FlOPs) levels (two biomarkers of damage) were measured. Associations between biomarkers and 1) ever asthma and 2) asthma attacks, asthma control and lung function in participants with asthma were evaluated using regression models adjusted for age, sex and smoking.Biomarkers of response were unrelated to asthma outcomes. Higher 8-isoprostane levels were significantly associated with ever asthma (odds ratio for one interquartile range increase 1.28 (95% CI 1.06-1.67). Among participants with asthma, 8-isoprostane levels were negatively associated with adult-onset asthma (0.63, 0.41-0.97) and FlOPs levels were positively associated with asthma attacks (1.33, 1.07-1.65), poor asthma control (1.30, 1.02-1.66) and poor lung function (1.34, 1.04-1.74).Our results suggest that 8-isoprostanes are involved in childhood-onset asthma and FlOPs are linked to asthma expression.
AbstractList Asthma is an oxidative stress related disease, but associations with asthma outcomes are poorly studied in adults. We aimed to study the associations between several biomarkers related to oxidative stress and various asthma outcomes.Cross-sectional analyses were conducted in 1388 adults (mean age 43 years, 44% with asthma) from the Epidemiological Study of the Genetics and Environment of Asthma (EGEA2). Three blood antioxidant enzyme activities (biomarkers of response to oxidative stress) and exhaled breath condensate 8-isoprostanes and plasma fluorescent oxidation products (FlOPs) levels (two biomarkers of damage) were measured. Associations between biomarkers and 1) ever asthma and 2) asthma attacks, asthma control and lung function in participants with asthma were evaluated using regression models adjusted for age, sex and smoking.Biomarkers of response were unrelated to asthma outcomes. Higher 8-isoprostane levels were significantly associated with ever asthma (odds ratio for one interquartile range increase 1.28 (95% CI 1.06-1.67). Among participants with asthma, 8-isoprostane levels were negatively associated with adult-onset asthma (0.63, 0.41-0.97) and FlOPs levels were positively associated with asthma attacks (1.33, 1.07-1.65), poor asthma control (1.30, 1.02-1.66) and poor lung function (1.34, 1.04-1.74).Our results suggest that 8-isoprostanes are involved in childhood-onset asthma and FlOPs are linked to asthma expression.Asthma is an oxidative stress related disease, but associations with asthma outcomes are poorly studied in adults. We aimed to study the associations between several biomarkers related to oxidative stress and various asthma outcomes.Cross-sectional analyses were conducted in 1388 adults (mean age 43 years, 44% with asthma) from the Epidemiological Study of the Genetics and Environment of Asthma (EGEA2). Three blood antioxidant enzyme activities (biomarkers of response to oxidative stress) and exhaled breath condensate 8-isoprostanes and plasma fluorescent oxidation products (FlOPs) levels (two biomarkers of damage) were measured. Associations between biomarkers and 1) ever asthma and 2) asthma attacks, asthma control and lung function in participants with asthma were evaluated using regression models adjusted for age, sex and smoking.Biomarkers of response were unrelated to asthma outcomes. Higher 8-isoprostane levels were significantly associated with ever asthma (odds ratio for one interquartile range increase 1.28 (95% CI 1.06-1.67). Among participants with asthma, 8-isoprostane levels were negatively associated with adult-onset asthma (0.63, 0.41-0.97) and FlOPs levels were positively associated with asthma attacks (1.33, 1.07-1.65), poor asthma control (1.30, 1.02-1.66) and poor lung function (1.34, 1.04-1.74).Our results suggest that 8-isoprostanes are involved in childhood-onset asthma and FlOPs are linked to asthma expression.
Asthma is an oxidative stress related disease, but associations with asthma outcomes are poorly studied in adults. We aimed to study the associations between several biomarkers related to oxidative stress and various asthma outcomes.Cross-sectional analyses were conducted in 1388 adults (mean age 43 years, 44% with asthma) from the Epidemiological Study of the Genetics and Environment of Asthma (EGEA2). Three blood antioxidant enzyme activities (biomarkers of response to oxidative stress) and exhaled breath condensate 8-isoprostanes and plasma fluorescent oxidation products (FlOPs) levels (two biomarkers of damage) were measured. Associations between biomarkers and 1) ever asthma and 2) asthma attacks, asthma control and lung function in participants with asthma were evaluated using regression models adjusted for age, sex and smoking.Biomarkers of response were unrelated to asthma outcomes. Higher 8-isoprostane levels were significantly associated with ever asthma (odds ratio for one interquartile range increase 1.28 (95% CI 1.06-1.67). Among participants with asthma, 8-isoprostane levels were negatively associated with adult-onset asthma (0.63, 0.41-0.97) and FlOPs levels were positively associated with asthma attacks (1.33, 1.07-1.65), poor asthma control (1.30, 1.02-1.66) and poor lung function (1.34, 1.04-1.74).Our results suggest that 8-isoprostanes are involved in childhood-onset asthma and FlOPs are linked to asthma expression.
Author Le Moual, Nicole
Huyvaert, Helene
Zerimech, Farid
Akiki, Zeina
Andrianjafimasy, Miora
Siroux, Valérie
Matran, Régis
Nadif, Rachel
Dumas, Orianne
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  givenname: Miora
  surname: Andrianjafimasy
  fullname: Andrianjafimasy, Miora
  email: miora.andrianjafimasy@inserm.fr
  organization: Univ Versailles St-Quentin-en-Yvelines, UMR-S 1168, Montigny-le-Bretonneux, France
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  givenname: Farid
  surname: Zerimech
  fullname: Zerimech, Farid
  organization: Université de Lille, EA4483, IMPECS, Institut Pasteur de Lille, Lille, France
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  surname: Akiki
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  organization: Univ Versailles St-Quentin-en-Yvelines, UMR-S 1168, Montigny-le-Bretonneux, France
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  surname: Huyvaert
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  surname: Le Moual
  fullname: Le Moual, Nicole
  organization: Univ Versailles St-Quentin-en-Yvelines, UMR-S 1168, Montigny-le-Bretonneux, France
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  givenname: Valérie
  surname: Siroux
  fullname: Siroux, Valérie
  organization: Institute for Advanced Biosciences, Centre de Recherche UGA-Inserm U1209-CNRS UMR 5309, Équipe d'Épidémiologie Environnementale, Site Santé, Allée des Alpes, La Tronche, France
– sequence: 7
  givenname: Régis
  surname: Matran
  fullname: Matran, Régis
  organization: Univ Lille Nord de France, Lille, France
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  givenname: Orianne
  orcidid: 0000-0001-8423-2826
  surname: Dumas
  fullname: Dumas, Orianne
  organization: Univ Versailles St-Quentin-en-Yvelines, UMR-S 1168, Montigny-le-Bretonneux, France
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  givenname: Rachel
  orcidid: 0000-0003-4938-9339
  surname: Nadif
  fullname: Nadif, Rachel
  organization: Univ Versailles St-Quentin-en-Yvelines, UMR-S 1168, Montigny-le-Bretonneux, France
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29284685$$D View this record in MEDLINE/PubMed
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Snippet Asthma is an oxidative stress related disease, but associations with asthma outcomes are poorly studied in adults. We aimed to study the associations between...
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SubjectTerms Adult
Age of Onset
Asthma - blood
Asthma - physiopathology
Biomarkers
Breath Tests
Cohort Studies
Cross-Sectional Studies
Dinoprost - analogs & derivatives
Dinoprost - analysis
Exhalation
Female
Forced Expiratory Volume
Humans
Male
Middle Aged
Nitric Oxide - analysis
Oxidative Stress
Oxygen - chemistry
Regression Analysis
Title Oxidative stress biomarkers and asthma characteristics in adults of the EGEA study
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