ABO blood group and von Willebrand factor: biological implications

ABO blood group antigens are complex carbohydrate molecules expressed on the surface of red blood cells and a variety of human cells and tissues. It is well known that ABO blood type exerts a profound influence on hemostasis, being a major determinant of von Willebrand factor (VWF), and consequently...

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Veröffentlicht in:Clinical chemistry and laboratory medicine Jg. 52; H. 9; S. 1273
Hauptverfasser: Franchini, Massimo, Crestani, Silvia, Frattini, Francesco, Sissa, Cinzia, Bonfanti, Carlo
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Germany 01.09.2014
Schlagworte:
ABO Blood-Group System - physiology
ADAM Proteins - blood
ADAMTS13 Protein
Glycosylation
Hemostasis - physiology
Humans
Phenotype
von Willebrand Diseases - blood
von Willebrand Factor - chemistry
von Willebrand Factor - physiology
ISSN:1437-4331, 1437-4331
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Zusammenfassung:ABO blood group antigens are complex carbohydrate molecules expressed on the surface of red blood cells and a variety of human cells and tissues. It is well known that ABO blood type exerts a profound influence on hemostasis, being a major determinant of von Willebrand factor (VWF), and consequently factor VIII, plasma levels. In this review, we will focus on the molecular mechanisms underlying the interaction between ABO blood group and VWF in normal and pathological conditions.
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ObjectType-Review-3
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ISSN:1437-4331
1437-4331
DOI:10.1515/cclm-2014-0564