Pentylenetetrazole-Induced Kindling Mouse Model

Pentylenetetrazole (PTZ) is a GABA-A receptor antagonist. An intraperitoneal injection of PTZ into an animal induces an acute, severe seizure at a high dose, whereas sequential injections of a subconvulsive dose have been used for the development of chemical kindling, an epilepsy model. A single low...

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Bibliographic Details
Published in:	Journal of visualized experiments no. 136
Main Authors:	Shimada, Tadayuki, Yamagata, Kanato
Format:	Journal Article
Language:	English
Published:	United States MyJove Corporation 12.06.2018
Subjects:	animal models animals antagonists brain chronic diseases drugs epilepsy gamma-aminobutyric acid receptors genes histology intraperitoneal injection neurons Neuroscience pathophysiology patients screening seizures
ISSN:	1940-087X, 1940-087X
Online Access:	Get full text
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