Epidemiology of Renal Cell Carcinoma: 2022 Update

We explored the global incidence and mortality of kidney cancer as well as its risk factors. We also highlight germline and somatic mutations that predispose to kidney cancer development. The data provide an insight into the complexity of kidney cancer epidemiology and germline and somatic mutations...

Full description

Saved in:
Bibliographic Details
Published in:European urology Vol. 82; no. 5; pp. 529 - 542
Main Authors: Bukavina, Laura, Bensalah, Karim, Bray, Freddie, Carlo, Maria, Challacombe, Ben, Karam, Jose A., Kassouf, Wassim, Mitchell, Thomas, Montironi, Rodolfo, O'Brien, Tim, Panebianco, Valeria, Scelo, Ghislaine, Shuch, Brian, van Poppel, Hein, Blosser, Christopher D., Psutka, Sarah P.
Format: Journal Article
Language:English
Published: Switzerland Elsevier B.V 01.11.2022
Subjects:
Biological Products
Carcinoma, Renal Cell - epidemiology
Carcinoma, Renal Cell - genetics
Epidemiology
Humans
Hypertension - complications
Kidney cancer
Kidney Neoplasms - epidemiology
Kidney Neoplasms - genetics
Obesity - epidemiology
Renal cell carcinoma
Risk factors
Tumors of the kidney
Tumors of the kidney
Renal cell carcinoma
Epidemiology
Risk factors
Kidney cancer
ISSN:0302-2838, 1873-7560, 1873-7560
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We explored the global incidence and mortality of kidney cancer as well as its risk factors. We also highlight germline and somatic mutations that predispose to kidney cancer development. The data provide an insight into the complexity of kidney cancer epidemiology and germline and somatic mutations in patients at risk of developing kidney cancer. International variations in the rates of kidney cancer (KC) are considerable. An understanding of the risk factors for KC development is necessary to generate opportunities to reduce its incidence through prevention and surveillance. To retrieve and summarize global incidence and mortality rates of KC and risk factors associated with its development, and to describe known familial syndromes and genetic alterations that represent biologic risk factors. A systematic review was conducted via Medline (PubMed) and Scopus to include meta-analyses, reviews, and original studies regarding renal cell carcinoma, epidemiology, and risk factors. Our narrative review provides a detailed analysis of KC incidence and mortality, with significant variations across time, geography, and sex. In particular, while KC incidence has continued to increase, mortality models have leveled off. Among the many risk factors, hypertension, obesity, and smoking are the most well established. The emergence of new genetic data coupled with observational data allows for integrated management and surveillance strategies for KC care. KC incidence and mortality rates vary significantly by geography, sex, and age. Associations of the development of KC with modifiable and fixed risk factors such as obesity, hypertension, smoking, and chronic kidney disease (CKD)/end-stage kidney disease (ESKD) are well described. Recent advances in the genetic characterization of these cancers have led to a better understanding of the germline and somatic mutations that predispose patients to KC development, with potential for identification of therapeutic targets that may improve outcomes for these at-risk patients. We reviewed evidence on the occurrence of kidney cancer (KC) around the world. Currently, the main avoidable causes are smoking, obesity, and high blood pressure. Although other risk factors also contribute, prevention and treatment of these three factors provide the best opportunities to reduce the risk of developing KC at present.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ObjectType-Undefined-4
ISSN:0302-2838
1873-7560
1873-7560
DOI:10.1016/j.eururo.2022.08.019