Epidemiology of Renal Cell Carcinoma: 2022 Update
We explored the global incidence and mortality of kidney cancer as well as its risk factors. We also highlight germline and somatic mutations that predispose to kidney cancer development. The data provide an insight into the complexity of kidney cancer epidemiology and germline and somatic mutations...
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| Published in: | European urology Vol. 82; no. 5; pp. 529 - 542 |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Switzerland
Elsevier B.V
01.11.2022
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| Subjects: | |
| ISSN: | 0302-2838, 1873-7560, 1873-7560 |
| Online Access: | Get full text |
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| Abstract | We explored the global incidence and mortality of kidney cancer as well as its risk factors. We also highlight germline and somatic mutations that predispose to kidney cancer development. The data provide an insight into the complexity of kidney cancer epidemiology and germline and somatic mutations in patients at risk of developing kidney cancer.
International variations in the rates of kidney cancer (KC) are considerable. An understanding of the risk factors for KC development is necessary to generate opportunities to reduce its incidence through prevention and surveillance.
To retrieve and summarize global incidence and mortality rates of KC and risk factors associated with its development, and to describe known familial syndromes and genetic alterations that represent biologic risk factors.
A systematic review was conducted via Medline (PubMed) and Scopus to include meta-analyses, reviews, and original studies regarding renal cell carcinoma, epidemiology, and risk factors.
Our narrative review provides a detailed analysis of KC incidence and mortality, with significant variations across time, geography, and sex. In particular, while KC incidence has continued to increase, mortality models have leveled off. Among the many risk factors, hypertension, obesity, and smoking are the most well established. The emergence of new genetic data coupled with observational data allows for integrated management and surveillance strategies for KC care.
KC incidence and mortality rates vary significantly by geography, sex, and age. Associations of the development of KC with modifiable and fixed risk factors such as obesity, hypertension, smoking, and chronic kidney disease (CKD)/end-stage kidney disease (ESKD) are well described. Recent advances in the genetic characterization of these cancers have led to a better understanding of the germline and somatic mutations that predispose patients to KC development, with potential for identification of therapeutic targets that may improve outcomes for these at-risk patients.
We reviewed evidence on the occurrence of kidney cancer (KC) around the world. Currently, the main avoidable causes are smoking, obesity, and high blood pressure. Although other risk factors also contribute, prevention and treatment of these three factors provide the best opportunities to reduce the risk of developing KC at present. |
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| AbstractList | International variations in the rates of kidney cancer (KC) are considerable. An understanding of the risk factors for KC development is necessary to generate opportunities to reduce its incidence through prevention and surveillance.
To retrieve and summarize global incidence and mortality rates of KC and risk factors associated with its development, and to describe known familial syndromes and genetic alterations that represent biologic risk factors.
A systematic review was conducted via Medline (PubMed) and Scopus to include meta-analyses, reviews, and original studies regarding renal cell carcinoma, epidemiology, and risk factors.
Our narrative review provides a detailed analysis of KC incidence and mortality, with significant variations across time, geography, and sex. In particular, while KC incidence has continued to increase, mortality models have leveled off. Among the many risk factors, hypertension, obesity, and smoking are the most well established. The emergence of new genetic data coupled with observational data allows for integrated management and surveillance strategies for KC care.
KC incidence and mortality rates vary significantly by geography, sex, and age. Associations of the development of KC with modifiable and fixed risk factors such as obesity, hypertension, smoking, and chronic kidney disease (CKD)/end-stage kidney disease (ESKD) are well described. Recent advances in the genetic characterization of these cancers have led to a better understanding of the germline and somatic mutations that predispose patients to KC development, with potential for identification of therapeutic targets that may improve outcomes for these at-risk patients.
We reviewed evidence on the occurrence of kidney cancer (KC) around the world. Currently, the main avoidable causes are smoking, obesity, and high blood pressure. Although other risk factors also contribute, prevention and treatment of these three factors provide the best opportunities to reduce the risk of developing KC at present. We explored the global incidence and mortality of kidney cancer as well as its risk factors. We also highlight germline and somatic mutations that predispose to kidney cancer development. The data provide an insight into the complexity of kidney cancer epidemiology and germline and somatic mutations in patients at risk of developing kidney cancer. International variations in the rates of kidney cancer (KC) are considerable. An understanding of the risk factors for KC development is necessary to generate opportunities to reduce its incidence through prevention and surveillance. To retrieve and summarize global incidence and mortality rates of KC and risk factors associated with its development, and to describe known familial syndromes and genetic alterations that represent biologic risk factors. A systematic review was conducted via Medline (PubMed) and Scopus to include meta-analyses, reviews, and original studies regarding renal cell carcinoma, epidemiology, and risk factors. Our narrative review provides a detailed analysis of KC incidence and mortality, with significant variations across time, geography, and sex. In particular, while KC incidence has continued to increase, mortality models have leveled off. Among the many risk factors, hypertension, obesity, and smoking are the most well established. The emergence of new genetic data coupled with observational data allows for integrated management and surveillance strategies for KC care. KC incidence and mortality rates vary significantly by geography, sex, and age. Associations of the development of KC with modifiable and fixed risk factors such as obesity, hypertension, smoking, and chronic kidney disease (CKD)/end-stage kidney disease (ESKD) are well described. Recent advances in the genetic characterization of these cancers have led to a better understanding of the germline and somatic mutations that predispose patients to KC development, with potential for identification of therapeutic targets that may improve outcomes for these at-risk patients. We reviewed evidence on the occurrence of kidney cancer (KC) around the world. Currently, the main avoidable causes are smoking, obesity, and high blood pressure. Although other risk factors also contribute, prevention and treatment of these three factors provide the best opportunities to reduce the risk of developing KC at present. International variations in the rates of kidney cancer (KC) are considerable. An understanding of the risk factors for KC development is necessary to generate opportunities to reduce its incidence through prevention and surveillance.CONTEXTInternational variations in the rates of kidney cancer (KC) are considerable. An understanding of the risk factors for KC development is necessary to generate opportunities to reduce its incidence through prevention and surveillance.To retrieve and summarize global incidence and mortality rates of KC and risk factors associated with its development, and to describe known familial syndromes and genetic alterations that represent biologic risk factors.OBJECTIVETo retrieve and summarize global incidence and mortality rates of KC and risk factors associated with its development, and to describe known familial syndromes and genetic alterations that represent biologic risk factors.A systematic review was conducted via Medline (PubMed) and Scopus to include meta-analyses, reviews, and original studies regarding renal cell carcinoma, epidemiology, and risk factors.EVIDENCE ACQUISITIONA systematic review was conducted via Medline (PubMed) and Scopus to include meta-analyses, reviews, and original studies regarding renal cell carcinoma, epidemiology, and risk factors.Our narrative review provides a detailed analysis of KC incidence and mortality, with significant variations across time, geography, and sex. In particular, while KC incidence has continued to increase, mortality models have leveled off. Among the many risk factors, hypertension, obesity, and smoking are the most well established. The emergence of new genetic data coupled with observational data allows for integrated management and surveillance strategies for KC care.EVIDENCE SYNTHESISOur narrative review provides a detailed analysis of KC incidence and mortality, with significant variations across time, geography, and sex. In particular, while KC incidence has continued to increase, mortality models have leveled off. Among the many risk factors, hypertension, obesity, and smoking are the most well established. The emergence of new genetic data coupled with observational data allows for integrated management and surveillance strategies for KC care.KC incidence and mortality rates vary significantly by geography, sex, and age. Associations of the development of KC with modifiable and fixed risk factors such as obesity, hypertension, smoking, and chronic kidney disease (CKD)/end-stage kidney disease (ESKD) are well described. Recent advances in the genetic characterization of these cancers have led to a better understanding of the germline and somatic mutations that predispose patients to KC development, with potential for identification of therapeutic targets that may improve outcomes for these at-risk patients.CONCLUSIONSKC incidence and mortality rates vary significantly by geography, sex, and age. Associations of the development of KC with modifiable and fixed risk factors such as obesity, hypertension, smoking, and chronic kidney disease (CKD)/end-stage kidney disease (ESKD) are well described. Recent advances in the genetic characterization of these cancers have led to a better understanding of the germline and somatic mutations that predispose patients to KC development, with potential for identification of therapeutic targets that may improve outcomes for these at-risk patients.We reviewed evidence on the occurrence of kidney cancer (KC) around the world. Currently, the main avoidable causes are smoking, obesity, and high blood pressure. Although other risk factors also contribute, prevention and treatment of these three factors provide the best opportunities to reduce the risk of developing KC at present.PATIENT SUMMARYWe reviewed evidence on the occurrence of kidney cancer (KC) around the world. Currently, the main avoidable causes are smoking, obesity, and high blood pressure. Although other risk factors also contribute, prevention and treatment of these three factors provide the best opportunities to reduce the risk of developing KC at present. |
| Author | Bensalah, Karim Bukavina, Laura Montironi, Rodolfo Scelo, Ghislaine Blosser, Christopher D. van Poppel, Hein Mitchell, Thomas O'Brien, Tim Shuch, Brian Karam, Jose A. Carlo, Maria Kassouf, Wassim Panebianco, Valeria Psutka, Sarah P. Bray, Freddie Challacombe, Ben |
| Author_xml | – sequence: 1 givenname: Laura surname: Bukavina fullname: Bukavina, Laura organization: Division of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA – sequence: 2 givenname: Karim surname: Bensalah fullname: Bensalah, Karim organization: Department of Urology, University of Rennes, Rennes, France – sequence: 3 givenname: Freddie surname: Bray fullname: Bray, Freddie organization: Cancer Surveillance Section, International Agency for Research on Cancer, Lyon, France – sequence: 4 givenname: Maria surname: Carlo fullname: Carlo, Maria organization: Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 5 givenname: Ben surname: Challacombe fullname: Challacombe, Ben organization: Department of Urology, Guy’s and St. Thomas Hospitals, London, UK – sequence: 6 givenname: Jose A. surname: Karam fullname: Karam, Jose A. organization: Departments of Urology and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA – sequence: 7 givenname: Wassim surname: Kassouf fullname: Kassouf, Wassim organization: Division of Adult Urology, McGill University, Montreal, Canada – sequence: 8 givenname: Thomas surname: Mitchell fullname: Mitchell, Thomas organization: Department of Urology, Wellcome Sanger Institute, Cambridge, UK – sequence: 9 givenname: Rodolfo surname: Montironi fullname: Montironi, Rodolfo organization: Molecular Medicine and Cell Therapy Foundation, Polytechnic University of the Marche Region, Ancona, Italy – sequence: 10 givenname: Tim surname: O'Brien fullname: O'Brien, Tim organization: Department of Urology, Guy’s and St. Thomas Hospitals, London, UK – sequence: 11 givenname: Valeria surname: Panebianco fullname: Panebianco, Valeria organization: Department of Radiology, Sapienza University of Roma, Rome, Italy – sequence: 12 givenname: Ghislaine surname: Scelo fullname: Scelo, Ghislaine organization: International Agency for Research on Cancer, Lyon, France – sequence: 13 givenname: Brian surname: Shuch fullname: Shuch, Brian organization: Department of Urology, University of California-Los Angeles, Los Angeles, CA, USA – sequence: 14 givenname: Hein surname: van Poppel fullname: van Poppel, Hein organization: Department of Urology, Catholic University of Leuven, Leuven, Belgium – sequence: 15 givenname: Christopher D. surname: Blosser fullname: Blosser, Christopher D. organization: Department of Medicine, University of Washington and Seattle Children’s Hospital, Seattle, WA, USA – sequence: 16 givenname: Sarah P. surname: Psutka fullname: Psutka, Sarah P. email: spsutka@uw.edu organization: Department of Medicine, University of Washington and Seattle Children’s Hospital, Seattle, WA, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36100483$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Biological Products Carcinoma, Renal Cell - epidemiology Carcinoma, Renal Cell - genetics Epidemiology Humans Hypertension - complications Kidney cancer Kidney Neoplasms - epidemiology Kidney Neoplasms - genetics Obesity - epidemiology Renal cell carcinoma Risk factors Tumors of the kidney |
| Title | Epidemiology of Renal Cell Carcinoma: 2022 Update |
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