Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of Scutellariae baicalensis radix Extract and Chitosan for Periodontal Diseases Treatment

Scutellaria baicalensis root displays anti-inflammatory and antibacterial properties due to the presence of flavonoids, particularly baicalin, baicalein, and wogonin. Our work aimed at developing thermosensitive hydrogels containing a binary mixture of S. baicalensis radix lyophilized extract and ch...

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Published in:	International journal of molecular sciences Vol. 22; no. 21; p. 11319
Main Authors:	Chanaj-Kaczmarek, Justyna, Osmałek, Tomasz, Szymańska, Emilia, Winnicka, Katarzyna, Karpiński, Tomasz M., Dyba, Magdalena, Bekalarska-Dębek, Marta, Cielecka-Piontek, Judyta
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 20.10.2021 MDPI
Subjects:	Animals Antibiotics Bacteria Biopolymers Cellulose Chitosan - administration & dosage Chitosan - pharmacology Chromatography Cytokines Dental plaque Disease Drugs, Chinese Herbal - pharmacology Flavanones - pharmacology Flavonoids Flavonoids - pharmacology Fourier transforms Gum disease Hydrogels Hydrogels - analysis Hydrogels - chemistry Hydrogels - pharmacology Kinases Ligaments Microorganisms Mouth Mucosa - drug effects Mouth Mucosa - metabolism Periodontal Diseases - drug therapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Roots Polymers Proteins Scutellaria baicalensis - metabolism Signal transduction Spectrum analysis Swine Viscosity chitosan dissolution studies Scutellaria baicalensis periodontal diseases ex vivo mucoadhesion permeability
ISSN:	1422-0067, 1661-6596, 1422-0067
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Abstract	Scutellaria baicalensis root displays anti-inflammatory and antibacterial properties due to the presence of flavonoids, particularly baicalin, baicalein, and wogonin. Our work aimed at developing thermosensitive hydrogels containing a binary mixture of S. baicalensis radix lyophilized extract and chitosan as a novel approach for periodontal diseases treatment. Two types of chitosan were employed in preliminary studies on binary mixtures with S. baicalensis radix lyophilized extract standardized for baicalin, baicalein, and wogonin. Thermosensitive hydrogels were prepared of poloxamer 407, alginate sodium, and cellulose derivatives and evaluated in terms of rheological and mucoadhesive behavior. The presence of chitosan altered the release profile of active compounds but did not affect their in vitro permeation behavior in PAMPA assay. The synergistic effects of S. baicalensis radix lyophilized extract and chitosan toward ferrous ion-chelating activity, inhibition of hyaluronidase, and pathogen growth were observed. The thermosensitive gelling system showed shear-thinning properties, gelation temperature between 25 and 27 °C, and favorable mucoadhesiveness in contact with porcine buccal mucosa, which was enhanced in the presence of binary mixture of S. baicalensis radix extract and chitosan. The release tests showed that baicalin and baicalein were liberated in a prolonged manner with a fast onset from hydrogel formulations.
AbstractList	Scutellaria baicalensis root displays anti-inflammatory and antibacterial properties due to the presence of flavonoids, particularly baicalin, baicalein, and wogonin. Our work aimed at developing thermosensitive hydrogels containing a binary mixture of S. baicalensis radix lyophilized extract and chitosan as a novel approach for periodontal diseases treatment. Two types of chitosan were employed in preliminary studies on binary mixtures with S. baicalensis radix lyophilized extract standardized for baicalin, baicalein, and wogonin. Thermosensitive hydrogels were prepared of poloxamer 407, alginate sodium, and cellulose derivatives and evaluated in terms of rheological and mucoadhesive behavior. The presence of chitosan altered the release profile of active compounds but did not affect their in vitro permeation behavior in PAMPA assay. The synergistic effects of S. baicalensis radix lyophilized extract and chitosan toward ferrous ion-chelating activity, inhibition of hyaluronidase, and pathogen growth were observed. The thermosensitive gelling system showed shear-thinning properties, gelation temperature between 25 and 27 °C, and favorable mucoadhesiveness in contact with porcine buccal mucosa, which was enhanced in the presence of binary mixture of S. baicalensis radix extract and chitosan. The release tests showed that baicalin and baicalein were liberated in a prolonged manner with a fast onset from hydrogel formulations.Scutellaria baicalensis root displays anti-inflammatory and antibacterial properties due to the presence of flavonoids, particularly baicalin, baicalein, and wogonin. Our work aimed at developing thermosensitive hydrogels containing a binary mixture of S. baicalensis radix lyophilized extract and chitosan as a novel approach for periodontal diseases treatment. Two types of chitosan were employed in preliminary studies on binary mixtures with S. baicalensis radix lyophilized extract standardized for baicalin, baicalein, and wogonin. Thermosensitive hydrogels were prepared of poloxamer 407, alginate sodium, and cellulose derivatives and evaluated in terms of rheological and mucoadhesive behavior. The presence of chitosan altered the release profile of active compounds but did not affect their in vitro permeation behavior in PAMPA assay. The synergistic effects of S. baicalensis radix lyophilized extract and chitosan toward ferrous ion-chelating activity, inhibition of hyaluronidase, and pathogen growth were observed. The thermosensitive gelling system showed shear-thinning properties, gelation temperature between 25 and 27 °C, and favorable mucoadhesiveness in contact with porcine buccal mucosa, which was enhanced in the presence of binary mixture of S. baicalensis radix extract and chitosan. The release tests showed that baicalin and baicalein were liberated in a prolonged manner with a fast onset from hydrogel formulations. root displays anti-inflammatory and antibacterial properties due to the presence of flavonoids, particularly baicalin, baicalein, and wogonin. Our work aimed at developing thermosensitive hydrogels containing a binary mixture of lyophilized extract and chitosan as a novel approach for periodontal diseases treatment. Two types of chitosan were employed in preliminary studies on binary mixtures with lyophilized extract standardized for baicalin, baicalein, and wogonin. Thermosensitive hydrogels were prepared of poloxamer 407, alginate sodium, and cellulose derivatives and evaluated in terms of rheological and mucoadhesive behavior. The presence of chitosan altered the release profile of active compounds but did not affect their in vitro permeation behavior in PAMPA assay. The synergistic effects of lyophilized extract and chitosan toward ferrous ion-chelating activity, inhibition of hyaluronidase, and pathogen growth were observed. The thermosensitive gelling system showed shear-thinning properties, gelation temperature between 25 and 27 °C, and favorable mucoadhesiveness in contact with porcine buccal mucosa, which was enhanced in the presence of binary mixture of extract and chitosan. The release tests showed that baicalin and baicalein were liberated in a prolonged manner with a fast onset from hydrogel formulations. Scutellaria baicalensis root displays anti-inflammatory and antibacterial properties due to the presence of flavonoids, particularly baicalin, baicalein, and wogonin. Our work aimed at developing thermosensitive hydrogels containing a binary mixture of S. baicalensis radix lyophilized extract and chitosan as a novel approach for periodontal diseases treatment. Two types of chitosan were employed in preliminary studies on binary mixtures with S. baicalensis radix lyophilized extract standardized for baicalin, baicalein, and wogonin. Thermosensitive hydrogels were prepared of poloxamer 407, alginate sodium, and cellulose derivatives and evaluated in terms of rheological and mucoadhesive behavior. The presence of chitosan altered the release profile of active compounds but did not affect their in vitro permeation behavior in PAMPA assay. The synergistic effects of S. baicalensis radix lyophilized extract and chitosan toward ferrous ion-chelating activity, inhibition of hyaluronidase, and pathogen growth were observed. The thermosensitive gelling system showed shear-thinning properties, gelation temperature between 25 and 27 °C, and favorable mucoadhesiveness in contact with porcine buccal mucosa, which was enhanced in the presence of binary mixture of S. baicalensis radix extract and chitosan. The release tests showed that baicalin and baicalein were liberated in a prolonged manner with a fast onset from hydrogel formulations.
Author	Cielecka-Piontek, Judyta Karpiński, Tomasz M. Osmałek, Tomasz Winnicka, Katarzyna Dyba, Magdalena Chanaj-Kaczmarek, Justyna Bekalarska-Dębek, Marta Szymańska, Emilia
AuthorAffiliation	5 Department of Prosthodontics and Dental Technology, Faculty of Dentistry, Poznan University of Medical Sciences, 70 Bukowska Street, 60-812 Poznan, Poland; magdalena.nowak@ump.edu.pl 6 Department of Conservative Dentistry and Periodontology, Faculty of Dentistry, Poznan University of Medical Sciences, 70 Bukowska Street, 60-812 Poznan, Poland; m.bekalarskadebek@ump.edu.pl 2 Department of Pharmaceutical Technology, Faculty of Pharmacy, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznan, Poland; tosmalek@ump.edu.pl 3 Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Bialystok, 2c Mickiewicza Street, 15-222 Białystok, Poland; emilia.szymanska@umb.edu.pl (E.S.); kwin@umb.edu.pl (K.W.) 4 Chair and Department of Medical Microbiology, Medical Faculty, Poznan University of Medical Sciences, 3 Wieniawskiego Street, 61-712 Poznan, Poland; tkarpin@ump.edu.pl 1 Department of Pharmacognosy, Faculty of Pharmacy, Poznan University of Medical Scie
AuthorAffiliation_xml	– name: 4 Chair and Department of Medical Microbiology, Medical Faculty, Poznan University of Medical Sciences, 3 Wieniawskiego Street, 61-712 Poznan, Poland; tkarpin@ump.edu.pl – name: 3 Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Bialystok, 2c Mickiewicza Street, 15-222 Białystok, Poland; emilia.szymanska@umb.edu.pl (E.S.); kwin@umb.edu.pl (K.W.) – name: 6 Department of Conservative Dentistry and Periodontology, Faculty of Dentistry, Poznan University of Medical Sciences, 70 Bukowska Street, 60-812 Poznan, Poland; m.bekalarskadebek@ump.edu.pl – name: 1 Department of Pharmacognosy, Faculty of Pharmacy, Poznan University of Medical Sciences, 4 Swiecickiego Street, 61-781 Poznan, Poland; justyna.chanaj-kaczmarek@ump.edu.pl – name: 5 Department of Prosthodontics and Dental Technology, Faculty of Dentistry, Poznan University of Medical Sciences, 70 Bukowska Street, 60-812 Poznan, Poland; magdalena.nowak@ump.edu.pl – name: 2 Department of Pharmaceutical Technology, Faculty of Pharmacy, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznan, Poland; tosmalek@ump.edu.pl
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Cites_doi	10.1080/00325481.2018.1396876 10.3390/antibiotics10070874 10.1016/j.arabjc.2017.08.002 10.1155/2014/563702 10.1177/0885328215614191 10.1016/j.supflu.2015.06.005 10.1016/j.heliyon.2017.e00390 10.1006/abbi.1994.1485 10.14336/AD.2017.0829 10.12968/denu.2002.29.3.144 10.1007/s10891-017-1676-9 10.1016/j.jinorgbio.2011.02.003 10.1016/j.ijbiomac.2020.11.036 10.1063/1.3203272 10.1111/j.1601-0825.2000.tb00325.x 10.1016/S0960-894X(01)00285-2 10.1007/s10856-010-4098-1 10.3390/pr8111468 10.1055/s-0032-1328764 10.1016/j.jinorgbio.2008.11.003 10.1016/j.archoralbio.2017.01.019 10.1007/s00784-010-0471-1 10.3390/agronomy9010021 10.1002/jrs.2166 10.3390/polym7111510 10.1002/jssc.201200156 10.1093/ecam/nep067 10.5504/BBEQ.2013.0027 10.1080/10717540590889781 10.1021/acs.jafc.8b01079 10.1111/j.1365-2842.2012.02341.x 10.1007/s00396-002-0808-7 10.1016/j.jcma.2017.04.013 10.1201/9781315194677-2 10.1016/j.archoralbio.2020.104770 10.1902/jop.2014.130635 10.1590/S0104-14282009000300013 10.1111/prd.12201 10.1016/j.ijbiomac.2013.03.039 10.21776/ub.jkb.2019.030.04.3 10.1159/000092853 10.4103/1947-2714.112473 10.1021/bm049813w 10.1016/S0891-5849(98)00315-3 10.3390/antiox4030447 10.1016/j.ijpharm.2014.03.038 10.1016/j.jobcr.2019.05.001 10.1111/j.1750-3841.2010.01755.x 10.15259/PCACD.21.06 10.1016/j.hermed.2021.100432 10.1208/s12249-010-9522-9 10.1208/s12249-009-9260-z 10.1111/j.1600-0765.2007.00989.x 10.3390/md14050095 10.1016/j.jep.2003.09.035 10.5455/jice.20160122065556 10.1080/10717540902861267 10.1016/0006-2952(90)90709-T 10.1002/ptr.3013 10.3390/app9235235 10.1016/S0308-8146(02)00180-2 10.3390/ijms130911194 10.3109/10837450.2010.508074 10.3390/ani11041039 10.4049/jimmunol.177.2.1272 10.1111/prd.12337 10.1186/s12937-016-0186-5 10.1016/j.ejps.2015.09.021 10.3390/molecules23092133 10.3390/jcm9010109 10.1016/j.archoralbio.2007.11.007 10.1371/journal.pone.0239316 10.2174/1381612826666200513112607 10.1385/IR:31:3:207 10.1111/ics.12072 10.1016/j.ajps.2014.09.005 10.1186/s13020-020-00384-0 10.1016/j.actbio.2020.09.018 10.3390/md13010141 10.3109/10837450902882351 10.1016/j.procbio.2015.02.007 10.3390/polym8090338 10.1248/cpb.40.1439 10.3390/ma4101861 10.1021/acs.biomac.7b01058 10.1016/j.ijpharm.2003.11.024 10.1186/s12906-021-03213-5 10.1155/2016/9130976 10.1177/2042098614554919 10.1136/postgradmedj-2017-134801 10.3109/13880209.2013.782505 10.1016/j.carbpol.2021.118117 10.1002/app.32056 10.3389/fimmu.2014.00101 10.3390/ma12091448 10.1016/j.hermed.2018.100254 10.1038/s41598-019-38916-w 10.1016/j.biomaterials.2014.10.024 10.1211/0022357001777621 10.3390/polym10030254 10.3390/pharmaceutics13030417 10.1016/j.jep.2006.08.001 10.3109/03639040903117348 10.1016/j.jds.2013.03.008 10.3390/medicines5040122 10.1177/0022034513494816 10.1016/j.ejps.2007.02.001 10.3390/ph13070153 10.1001/archinte.160.18.2749 10.3390/jcm9041208 10.1007/s11434-016-1136-5 10.3797/scipharm.0804-05 10.1111/j.1600-051X.1998.tb02420.x 10.1007/s11095-006-9104-4 10.1152/physrev.00052.2009
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Copyright_xml	– notice: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2021 by the authors. 2021
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References	Froelich (ref_39) 2014; 466 ref_90 Ozma (ref_26) 2021; 27 ref_12 Xu (ref_33) 2015; 37 ref_99 ref_10 Amorati (ref_74) 2018; 66 Lopez (ref_109) 2021; 267 Kim (ref_108) 2003; 281 Lee (ref_95) 2010; 75 Perez (ref_81) 2009; 103 Dumortier (ref_37) 2006; 23 Akcali (ref_7) 2013; 40 Waddington (ref_8) 2000; 6 Kurutas (ref_75) 2016; 15 Nallamuthu (ref_76) 2015; 10 ref_126 Li (ref_24) 2004; 39 ref_127 Chen (ref_28) 2017; 78 Liang (ref_42) 2004; 5 Popova (ref_6) 2013; 27 Janakiram (ref_5) 2020; 84 ref_122 ref_124 ref_123 ref_27 Shapovalov (ref_107) 2017; 90 Banerjee (ref_40) 2013; 57 Roy (ref_111) 2010; 117 Yan (ref_59) 2015; 104 ref_72 Pai (ref_49) 2004; 90 Zhao (ref_16) 2016; 61 Yamalik (ref_83) 1998; 25 Tigga (ref_97) 2019; 22 Mao (ref_98) 2021; 166 Xu (ref_58) 2013; 79 Akao (ref_69) 2000; 52 Mohamed (ref_104) 2012; 13 Baloglu (ref_106) 2011; 16 ref_78 Zeng (ref_96) 2015; 50 Joshi (ref_44) 2011; 4 Sosnowska (ref_125) 2015; 7 ref_73 Zillich (ref_113) 2013; 35 Pakzad (ref_36) 2016; 30 Arancibia (ref_30) 2013; 92 Kim (ref_18) 2018; 81 Bansal (ref_43) 2009; 10 Llor (ref_11) 2014; 5 Kuppusamy (ref_91) 1990; 40 Maestrelli (ref_64) 2004; 271 Wang (ref_34) 2020; 116 Wang (ref_21) 2006; 77 Song (ref_66) 2020; 15 Palombo (ref_15) 2011; 2011 Forouzanfar (ref_51) 2020; 26 Kmiec (ref_31) 2017; 2 Goy (ref_102) 2009; 19 Giampieri (ref_70) 2015; 4 Dinis (ref_121) 1994; 315 Xie (ref_80) 2001; 11 Puranik (ref_13) 2015; 1 Chen (ref_20) 2008; 76 Nema (ref_92) 2013; 51 Fischer (ref_119) 2007; 31 Re (ref_120) 1999; 26 ref_56 Kakegawa (ref_94) 1992; 40 ref_54 ref_53 Liang (ref_68) 2017; 8 Roy (ref_110) 2009; 1152 Serpe (ref_114) 2016; 81 Graziani (ref_9) 2017; 75 Jiang (ref_86) 2011; 91 Cardoso (ref_4) 2018; 130 ref_61 Zhu (ref_25) 2007; 109 Gross (ref_3) 2017; 93 Cai (ref_19) 2008; 43 ref_65 Unsalan (ref_57) 2009; 40 ref_63 ref_62 Ng (ref_112) 2010; 11 Scheibner (ref_84) 2006; 177 Jang (ref_29) 2010; 24 Prabaharan (ref_52) 2004; 12 ref_115 Bovicelli (ref_82) 2011; 105 ref_116 Pignatello (ref_32) 2009; 16 ref_118 Sohi (ref_67) 2010; 36 Wang (ref_55) 2012; 35 Moore (ref_117) 1996; 20 ref_38 Safiaghdam (ref_50) 2018; 21 Huang (ref_17) 2013; 8 Li (ref_77) 2018; 11 Kamil (ref_79) 2002; 79 Dahiya (ref_87) 2013; 5 Pei (ref_22) 2014; 85 Pappu (ref_48) 2019; 15 Liana (ref_93) 2019; 30 Ramesh (ref_71) 2016; 5 Melo (ref_60) 2014; 13 Ertan (ref_105) 2009; 14 Sahariah (ref_103) 2017; 18 Ji (ref_35) 2010; 21 ref_47 ref_46 Kunimatsu (ref_23) 2020; 116 ref_41 ref_101 ref_1 Tanimoto (ref_85) 2008; 53 Da (ref_100) 2019; 9 Arweiler (ref_45) 2011; 15 Moseley (ref_88) 2002; 29 Wu (ref_2) 2000; 160 (ref_14) 2019; 9 Powell (ref_89) 2005; 31
References_xml	– volume: 130 start-page: 98 year: 2018 ident: ref_4 article-title: Chronic Periodontitis, Inflammatory Cytokines, and Interrelationship with Other Chronic Diseases publication-title: Postgrad. Med. doi: 10.1080/00325481.2018.1396876 – ident: ref_12 doi: 10.3390/antibiotics10070874 – volume: 11 start-page: 159 year: 2018 ident: ref_77 article-title: Structure-Activity Relationship of Eight High Content Flavonoids Analyzed with a Preliminary Assign-Score Method and Their Contribution to Antioxidant Ability of Flavonoids-Rich Extract from Scutellaria Baicalensis Shoots publication-title: Arab. J. Chem. doi: 10.1016/j.arabjc.2017.08.002 – ident: ref_54 doi: 10.1155/2014/563702 – volume: 30 start-page: 919 year: 2016 ident: ref_36 article-title: Thermosensitive Hydrogel for Periodontal Application: In Vitro Drug Release, Antibacterial Activity and Toxicity Evaluation publication-title: J. Biomater. Appl. doi: 10.1177/0885328215614191 – volume: 104 start-page: 177 year: 2015 ident: ref_59 article-title: Preparation and Characterization of Baicalein Powder Micronized by the SEDS Process publication-title: J. Supercrit. Fluids doi: 10.1016/j.supflu.2015.06.005 – ident: ref_38 doi: 10.1016/j.heliyon.2017.e00390 – volume: 315 start-page: 161 year: 1994 ident: ref_121 article-title: Action of Phenolic Derivatives (Acetaminophen, Salicylate, and 5-Aminosalicylate) as Inhibitors of Membrane Lipid Peroxidation and as Peroxyl Radical Scavengers publication-title: Arch Biochem. Biophys. doi: 10.1006/abbi.1994.1485 – volume: 8 start-page: 850 year: 2017 ident: ref_68 article-title: The Effects of Baicalin and Baicalein on Cerebral Ischemia: A Review publication-title: Aging Dis. doi: 10.14336/AD.2017.0829 – volume: 29 start-page: 144 year: 2002 ident: ref_88 article-title: Hyaluronan and Its Potential Role in Periodontal Healing publication-title: Dent Update doi: 10.12968/denu.2002.29.3.144 – volume: 90 start-page: 1213 year: 2017 ident: ref_107 article-title: On the Applicability of the Ostwald–De Waele Model in Solving Applied Problems publication-title: J. Eng. Phys. Thermophy. doi: 10.1007/s10891-017-1676-9 – volume: 105 start-page: 693 year: 2011 ident: ref_82 article-title: In Vitro Analysis of Iron Chelating Activity of Flavonoids publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2011.02.003 – volume: 166 start-page: 1570 year: 2021 ident: ref_98 article-title: Chitosan Oligosaccharide-g-Linalool Polymer as Inhibitor of Hyaluronidase and Collagenase Activity publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2020.11.036 – volume: 1152 start-page: 210 year: 2009 ident: ref_110 article-title: Importance of Viscoelastic Property Measurement of a New Hydrogel for Health Care publication-title: AIP Conf. Proc. doi: 10.1063/1.3203272 – volume: 6 start-page: 138 year: 2000 ident: ref_8 article-title: Periodontal Disease Mechanisms: Reactive Oxygen Species: A Potential Role in the Pathogenesis of Periodontal Diseases publication-title: Oral Dis. doi: 10.1111/j.1601-0825.2000.tb00325.x – volume: 11 start-page: 1699 year: 2001 ident: ref_80 article-title: Antioxidant Activity of Water-Soluble Chitosan Derivatives publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/S0960-894X(01)00285-2 – volume: 21 start-page: 2435 year: 2010 ident: ref_35 article-title: A Novel Injectable Chlorhexidine Thermosensitive Hydrogel for Periodontal Application: Preparation, Antibacterial Activity and Toxicity Evaluation publication-title: J. Mater. Sci. Mater. Med. doi: 10.1007/s10856-010-4098-1 – ident: ref_65 doi: 10.3390/pr8111468 – volume: 79 start-page: 1068 year: 2013 ident: ref_58 article-title: Unveiling Ontogenesis of Herbal Medicine in Plant Chemical Profiles by Infrared Macro-Fingerprinting publication-title: Planta Med. doi: 10.1055/s-0032-1328764 – volume: 103 start-page: 326 year: 2009 ident: ref_81 article-title: Iron-Binding and Anti-Fenton Properties of Baicalein and Baicalin publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2008.11.003 – volume: 78 start-page: 100 year: 2017 ident: ref_28 article-title: Baicalein Enhances the Osteogenic Differentiation of Human Periodontal Ligament Cells by Activating the Wnt/β-Catenin Signaling Pathway publication-title: Arch. Oral Biol. doi: 10.1016/j.archoralbio.2017.01.019 – volume: 15 start-page: 909 year: 2011 ident: ref_45 article-title: Clinical and Antibacterial Effect of an Anti-Inflammatory Toothpaste Formulation with Scutellaria Baicalensis Extract on Experimental Gingivitis publication-title: Clin. Oral Investig. doi: 10.1007/s00784-010-0471-1 – ident: ref_63 doi: 10.3390/agronomy9010021 – volume: 40 start-page: 562 year: 2009 ident: ref_57 article-title: FT-Raman and FT-IR Spectral and Quantum Chemical Studies on Some Flavonoid Derivatives: Baicalein and Naringenin publication-title: J. Raman Spectrosc. doi: 10.1002/jrs.2166 – volume: 7 start-page: 2223 year: 2015 ident: ref_125 article-title: The Effect of β-Glycerophosphate Crosslinking on Chitosan Cytotoxicity and Properties of Hydrogels for Vaginal Application publication-title: Polymers doi: 10.3390/polym7111510 – volume: 35 start-page: 2223 year: 2012 ident: ref_55 article-title: Screening of Radical Scavengers in Scutellaria Baicalensis Using HPLC with Diode Array and Chemiluminescence Detection publication-title: J. Sep. Sci. doi: 10.1002/jssc.201200156 – ident: ref_56 – volume: 2011 start-page: enep067 year: 2011 ident: ref_15 article-title: Traditional Medicinal Plant Extracts and Natural Products with Activity against Oral Bacteria: Potential Application in the Prevention and Treatment of Oral Diseases publication-title: Evid.-Based Complementary Altern. Med. doi: 10.1093/ecam/nep067 – volume: 27 start-page: 3754 year: 2013 ident: ref_6 article-title: Microbiology of Periodontal Diseases. A Review publication-title: Biotechnol. Biotechnol. Equip. doi: 10.5504/BBEQ.2013.0027 – volume: 12 start-page: 41 year: 2004 ident: ref_52 article-title: Chitosan-Based Particles as Controlled Drug Delivery Systems publication-title: Drug Deliv. doi: 10.1080/10717540590889781 – volume: 66 start-page: 3324 year: 2018 ident: ref_74 article-title: Methods to Measure the Antioxidant Activity of Phytochemicals and Plant Extracts publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.8b01079 – volume: 40 start-page: 60 year: 2013 ident: ref_7 article-title: Periodontal Diseases and Stress: A Brief Review publication-title: J. Oral Rehabil. doi: 10.1111/j.1365-2842.2012.02341.x – volume: 281 start-page: 614 year: 2003 ident: ref_108 article-title: Rheological Properties and Microstructures of Carbopol Gel Network System publication-title: Colloid Polym. Sci. doi: 10.1007/s00396-002-0808-7 – volume: 81 start-page: 141 year: 2018 ident: ref_18 article-title: Scutellaria Baicalensis Ameliorates the Destruction of Periodontal Ligament via Inhibition of Inflammatory Cytokine Expression publication-title: J. Chin. Med Assoc. doi: 10.1016/j.jcma.2017.04.013 – ident: ref_47 doi: 10.1201/9781315194677-2 – volume: 116 start-page: 104770 year: 2020 ident: ref_23 article-title: Baicalin Inhibits Root Resorption during Tooth Movement in a Rodent Model publication-title: Arch. Oral Biol. doi: 10.1016/j.archoralbio.2020.104770 – volume: 1 start-page: 26 year: 2015 ident: ref_13 article-title: Herbs: A Good Alternatives to Current Treatments for Oral Health Problems publication-title: Int. J. Adv. Health Sci. – volume: 85 start-page: 1283 year: 2014 ident: ref_22 article-title: Response of Human Periodontal Ligament Cells to Baicalin publication-title: J. Periodontol. doi: 10.1902/jop.2014.130635 – volume: 19 start-page: 241 year: 2009 ident: ref_102 article-title: de Assis, O.B.G. A Review of the Antimicrobial Activity of Chitosan publication-title: Polímeros doi: 10.1590/S0104-14282009000300013 – volume: 75 start-page: 152 year: 2017 ident: ref_9 article-title: Nonsurgical and Surgical Treatment of Periodontitis: How Many Options for One Disease? publication-title: Periodontology 2000 doi: 10.1111/prd.12201 – volume: 57 start-page: 297 year: 2013 ident: ref_40 article-title: Trivalent Ion Cross-Linked PH Sensitive Alginate-Methyl Cellulose Blend Hydrogel Beads from Aqueous Template publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2013.03.039 – ident: ref_53 – volume: 30 start-page: 247 year: 2019 ident: ref_93 article-title: Antioxidant and Anti-Hyaluronidase Activities of Dragon Fruit Peel Extract and Kaempferol-3-O-Rutinoside publication-title: J. Kedokt. Brawijaya doi: 10.21776/ub.jkb.2019.030.04.3 – volume: 77 start-page: 71 year: 2006 ident: ref_21 article-title: Influence of Baicalin on the Expression of Receptor Activator of Nuclear Factor-ΚB Ligand in Cultured Human Periodontal Ligament Cells publication-title: Pharmacology doi: 10.1159/000092853 – volume: 5 start-page: 309 year: 2013 ident: ref_87 article-title: Hyaluronic Acid: A Boon in Periodontal Therapy publication-title: N. Am. J. Med. Sci. doi: 10.4103/1947-2714.112473 – ident: ref_115 – volume: 5 start-page: 1917 year: 2004 ident: ref_42 article-title: Novel Method Using a Temperature-Sensitive Polymer (Methylcellulose) to Thermally Gel Aqueous Alginate as a PH-Sensitive Hydrogel publication-title: Biomacromolecules doi: 10.1021/bm049813w – volume: 26 start-page: 1231 year: 1999 ident: ref_120 article-title: Antioxidant Activity Applying an Improved ABTS Radical Cation Decolorization Assay publication-title: Free Radic. Biol. Med. doi: 10.1016/S0891-5849(98)00315-3 – volume: 4 start-page: 447 year: 2015 ident: ref_70 article-title: Non-Nutrient, Naturally Occurring Phenolic Compounds with Antioxidant Activity for the Prevention and Treatment of Periodontal Diseases publication-title: Antioxidants doi: 10.3390/antiox4030447 – volume: 466 start-page: 328 year: 2014 ident: ref_39 article-title: Application of Gellan Gum in Pharmacy and Medicine publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2014.03.038 – volume: 9 start-page: 212 year: 2019 ident: ref_14 article-title: Herbal Medicine as Adjunct in Periodontal Therapies- A Review of Clinical Trials in Past Decade publication-title: J. Oral. Biol. Craniofac. Res. doi: 10.1016/j.jobcr.2019.05.001 – volume: 21 start-page: 978 year: 2018 ident: ref_50 article-title: Medicinal Plants for Gingivitis: A Review of Clinical Trials publication-title: Iran J. Basic. Med. Sci. – volume: 75 start-page: H212 year: 2010 ident: ref_95 article-title: Evaluation of Antioxidant and Inhibitory Activities for Different Subclasses Flavonoids on Enzymes for Rheumatoid Arthritis publication-title: J. Food Sci. doi: 10.1111/j.1750-3841.2010.01755.x – ident: ref_61 doi: 10.15259/PCACD.21.06 – volume: 27 start-page: 100432 year: 2021 ident: ref_26 article-title: Baicalin, a Natural Antimicrobial and Anti-Biofilm Agent publication-title: J. Herb. Med. doi: 10.1016/j.hermed.2021.100432 – volume: 11 start-page: 1432 year: 2010 ident: ref_112 article-title: Validation of a Static Franz Diffusion Cell System for In Vitro Permeation Studies publication-title: AAPS PharmSciTech doi: 10.1208/s12249-010-9522-9 – volume: 10 start-page: 716 year: 2009 ident: ref_43 article-title: Development of Satranidazole Mucoadhesive Gel for the Treatment of Periodontitis publication-title: AAPS PharmSciTech doi: 10.1208/s12249-009-9260-z – volume: 43 start-page: 14 year: 2008 ident: ref_19 article-title: Protective Effects of Baicalin on Ligature-Induced Periodontitis in Rats publication-title: J. Periodontal Res. doi: 10.1111/j.1600-0765.2007.00989.x – ident: ref_78 doi: 10.3390/md14050095 – volume: 90 start-page: 99 year: 2004 ident: ref_49 article-title: Evaluation of Antiplaque Activity of Azadirachta Indica Leaf Extract Gel—a 6-Week Clinical Study publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2003.09.035 – volume: 5 start-page: 92 year: 2016 ident: ref_71 article-title: Herbs as an Antioxidant Arsenal for Periodontal Diseases publication-title: J. Intercult. Ethnopharmacol. doi: 10.5455/jice.20160122065556 – volume: 16 start-page: 176 year: 2009 ident: ref_32 article-title: Chitosan Glutamate Hydrogels with Local Anesthetic Activity for Buccal Application publication-title: Drug Deliv. doi: 10.1080/10717540902861267 – volume: 40 start-page: 397 year: 1990 ident: ref_91 article-title: Structure-Activity Studies of Flavonoids as Inhibitors of Hyaluronidase publication-title: Biochem. Pharmacol. doi: 10.1016/0006-2952(90)90709-T – volume: 24 start-page: 964 year: 2010 ident: ref_29 article-title: Wogonin Inhibits Osteoclast Formation Induced by Lipopolysaccharide publication-title: Phytother. Res. doi: 10.1002/ptr.3013 – ident: ref_41 doi: 10.3390/app9235235 – volume: 79 start-page: 69 year: 2002 ident: ref_79 article-title: Antioxidative Activity of Chitosans of Different Viscosity in Cooked Comminuted Flesh of Herring (Clupea Harengus) publication-title: Food Chem. doi: 10.1016/S0308-8146(02)00180-2 – volume: 13 start-page: 11194 year: 2012 ident: ref_104 article-title: Synthesis and Antimicrobial Activity of Some Novel Cross-Linked Chitosan Hydrogels publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms130911194 – volume: 16 start-page: 627 year: 2011 ident: ref_106 article-title: Rheological and Mechanical Properties of Poloxamer Mixtures as a Mucoadhesive Gel Base publication-title: Pharm. Dev. Technol. doi: 10.3109/10837450.2010.508074 – ident: ref_101 doi: 10.3390/ani11041039 – volume: 177 start-page: 1272 year: 2006 ident: ref_84 article-title: Hyaluronan Fragments Act as an Endogenous Danger Signal by Engaging TLR2 publication-title: J. Immunol. doi: 10.4049/jimmunol.177.2.1272 – volume: 84 start-page: 202 year: 2020 ident: ref_5 article-title: A Public Health Approach for Prevention of Periodontal Disease publication-title: Periodontology 2000 doi: 10.1111/prd.12337 – volume: 15 start-page: 71 year: 2016 ident: ref_75 article-title: The Importance of Antioxidants Which Play the Role in Cellular Response against Oxidative/Nitrosative Stress: Current State publication-title: Nutr. J. doi: 10.1186/s12937-016-0186-5 – volume: 81 start-page: 52 year: 2016 ident: ref_114 article-title: Evaluation of Different Pig Oral Mucosa Sites as Permeability Barrier Models for Drug Permeation Studies publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2015.09.021 – ident: ref_122 doi: 10.3390/molecules23092133 – ident: ref_123 doi: 10.3390/jcm9010109 – volume: 53 start-page: 330 year: 2008 ident: ref_85 article-title: Inhibition of the Proliferation of Human Periodontal Ligament Fibroblasts by Hyaluronidase publication-title: Arch. Oral Biol. doi: 10.1016/j.archoralbio.2007.11.007 – ident: ref_99 doi: 10.1371/journal.pone.0239316 – volume: 26 start-page: 4277 year: 2020 ident: ref_51 article-title: Curcumin for the Management of Periodontal Diseases: A Review publication-title: Curr. Pharm. Des. doi: 10.2174/1381612826666200513112607 – volume: 31 start-page: 207 year: 2005 ident: ref_89 article-title: Threat Matrix. Low-molecular-weight hyaluronan (HA) as a danger signal publication-title: Immunol. Res. doi: 10.1385/IR:31:3:207 – volume: 35 start-page: 491 year: 2013 ident: ref_113 article-title: Release and in vitro skin permeation of polyphenols from cosmetic emulsions publication-title: Int. J. Cosmet. Sci. doi: 10.1111/ics.12072 – volume: 10 start-page: 203 year: 2015 ident: ref_76 article-title: Chlorogenic Acid Loaded Chitosan Nanoparticles with Sustained Release Property, Retained Antioxidant Activity and Enhanced Bioavailability publication-title: Asian J. Pharm. Sci. doi: 10.1016/j.ajps.2014.09.005 – volume: 15 start-page: 102 year: 2020 ident: ref_66 article-title: Applications, Phytochemistry, Pharmacological Effects, Pharmacokinetics, Toxicity of Scutellaria Baicalensis Georgi. and Its Probably Potential Therapeutic Effects on COVID-19: A Review publication-title: Chin. Med. doi: 10.1186/s13020-020-00384-0 – volume: 116 start-page: 259 year: 2020 ident: ref_34 article-title: Antimicrobial and Anti-Inflammatory Thermo-Reversible Hydrogel for Periodontal Delivery publication-title: Acta Biomater. doi: 10.1016/j.actbio.2020.09.018 – volume: 13 start-page: 141 year: 2014 ident: ref_60 article-title: Does the Use of Chitosan Contribute to Oxalate Kidney Stone Formation? publication-title: Mar. Drugs doi: 10.3390/md13010141 – volume: 14 start-page: 623 year: 2009 ident: ref_105 article-title: Benzydamine Hydrochloride Buccal Bioadhesive Gels Designed for Oral Ulcers: Preparation, Rheological, Textural, Mucoadhesive and Release Properties publication-title: Pharm. Dev. Technol. doi: 10.3109/10837450902882351 – volume: 50 start-page: 738 year: 2015 ident: ref_96 article-title: Spectroscopic and Molecular Modeling Investigation on the Interactions between Hyaluronidase and Baicalein and Chrysin publication-title: Process. Biochem. doi: 10.1016/j.procbio.2015.02.007 – ident: ref_62 doi: 10.3390/polym8090338 – volume: 40 start-page: 1439 year: 1992 ident: ref_94 article-title: Inhibitory Effects of Some Natural Products on the Activation of Hyaluronidase and Their Anti-Allergic Actions publication-title: Chem. Pharm. Bull. doi: 10.1248/cpb.40.1439 – volume: 4 start-page: 1861 year: 2011 ident: ref_44 article-title: Sol-Gel Behavior of Hydroxypropyl Methylcellulose (HPMC) in Ionic Media Including Drug Release publication-title: Materials doi: 10.3390/ma4101861 – volume: 18 start-page: 3846 year: 2017 ident: ref_103 article-title: Antimicrobial Chitosan and Chitosan Derivatives: A Review of the Structure–Activity Relationship publication-title: Biomacromolecules doi: 10.1021/acs.biomac.7b01058 – volume: 271 start-page: 257 year: 2004 ident: ref_64 article-title: Influence of Chitosan and Its Glutamate and Hydrochloride Salts on Naproxen Dissolution Rate and Permeation across Caco-2 Cells publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2003.11.024 – ident: ref_72 – ident: ref_27 doi: 10.1186/s12906-021-03213-5 – ident: ref_73 doi: 10.1155/2016/9130976 – volume: 5 start-page: 229 year: 2014 ident: ref_11 article-title: Antimicrobial Resistance: Risk Associated with Antibiotic Overuse and Initiatives to Reduce the Problem publication-title: Ther. Adv. Drug Saf. doi: 10.1177/2042098614554919 – volume: 93 start-page: 560 year: 2017 ident: ref_3 article-title: Periodontitis: A Global Disease and the Primary Care Provider’s Role publication-title: Postgrad. Med. J. doi: 10.1136/postgradmedj-2017-134801 – volume: 51 start-page: 1182 year: 2013 ident: ref_92 article-title: Matrix Metalloproteinase, Hyaluronidase and Elastase Inhibitory Potential of Standardized Extract of Centella Asiatica publication-title: Pharm. Biol. doi: 10.3109/13880209.2013.782505 – volume: 267 start-page: 118117 year: 2021 ident: ref_109 article-title: Oscillatory Rheology of Carboxymethyl Cellulose Gels: Influence of Concentration and PH publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2021.118117 – volume: 117 start-page: 1703 year: 2010 ident: ref_111 article-title: Novel Hydrogels of PVP–CMC and Their Swelling Effect on Viscoelastic Properties publication-title: J. Appl. Polym. Sci. doi: 10.1002/app.32056 – ident: ref_90 doi: 10.3389/fimmu.2014.00101 – volume: 2 start-page: 1 year: 2017 ident: ref_31 article-title: Chitosan-Properties and Applications in Dentistry publication-title: Adv. Tissue Eng. Regen. Med. – volume: 39 start-page: 197 year: 2004 ident: ref_24 article-title: Effects of baicalin on the expression of pro-MMP-1 and MMP-3 in human gingival fibroblasts and periodontal ligament cells publication-title: Zhonghua Kou Qiang Yi Xue Za Zhi – volume: 22 start-page: 1229 year: 2019 ident: ref_97 article-title: In-Vitro Hyaluronidase Inhibition Assay of Chitosan Extracted from Exoskeleton of Freshwater Edible Crab Sartoriana Spinigera publication-title: J. Exp. Zool. India – volume: 20 start-page: 64 year: 1996 ident: ref_117 article-title: Mathematical Comparison of Dissolution Profiles publication-title: Pharm. Technol. – ident: ref_10 doi: 10.3390/ma12091448 – volume: 15 start-page: 100254 year: 2019 ident: ref_48 article-title: Evaluation of Biodegradable Gel Containing Flax Seed Extract (Linum Usitatissimum) as a Targeted Drug Delivery for Management of Chronic Periodontitis publication-title: J. Herb. Med. doi: 10.1016/j.hermed.2018.100254 – volume: 9 start-page: 1683 year: 2019 ident: ref_100 article-title: Antifungal Activity and Mechanism of Action of Ou-Gon (Scutellaria Root Extract) Components against Pathogenic Fungi publication-title: Sci. Rep. doi: 10.1038/s41598-019-38916-w – volume: 37 start-page: 395 year: 2015 ident: ref_33 article-title: Genipin-Crosslinked Catechol-Chitosan Mucoadhesive Hydrogels for Buccal Drug Delivery publication-title: Biomaterials doi: 10.1016/j.biomaterials.2014.10.024 – volume: 52 start-page: 1563 year: 2000 ident: ref_69 article-title: Baicalin, the Predominant Flavone Glucuronide of Scutellariae Radix, Is Absorbed from the Rat Gastrointestinal Tract as the Aglycone and Restored to Its Original Form publication-title: J. Pharm. Pharmacol. doi: 10.1211/0022357001777621 – ident: ref_127 doi: 10.3390/polym10030254 – ident: ref_126 doi: 10.3390/pharmaceutics13030417 – volume: 109 start-page: 325 year: 2007 ident: ref_25 article-title: Inhibitory Effect of Flavonoid Baicalin on Degranulation of Human Polymorphonuclear Leukocytes Induced by Interleukin-8: Potential Role in Periodontal Diseases publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2006.08.001 – volume: 36 start-page: 254 year: 2010 ident: ref_67 article-title: Critical Evaluation of Permeation Enhancers for Oral Mucosal Drug Delivery publication-title: Drug Dev. Ind. Pharm. doi: 10.3109/03639040903117348 – volume: 8 start-page: 405 year: 2013 ident: ref_17 article-title: The Effect of Scutellaria Baicalensis Georgi on Immune Response in Mouse Model of Experimental Periodontitis publication-title: J. Dent. Sci. doi: 10.1016/j.jds.2013.03.008 – ident: ref_1 doi: 10.3390/medicines5040122 – volume: 92 start-page: 740 year: 2013 ident: ref_30 article-title: Effects of Chitosan Particles in Periodontal Pathogens and Gingival Fibroblasts publication-title: J. Dent Res. doi: 10.1177/0022034513494816 – ident: ref_116 – volume: 31 start-page: 32 year: 2007 ident: ref_119 article-title: Permeation of Permanently Positive Charged Molecules through Artificial Membranes--Influence of Physico-Chemical Properties publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2007.02.001 – ident: ref_124 doi: 10.3390/ph13070153 – ident: ref_46 – volume: 160 start-page: 2749 year: 2000 ident: ref_2 article-title: Periodontal Disease and Risk of Cerebrovascular Disease: The First National Health and Nutrition Examination Survey and Its Follow-up Study publication-title: Arch. Intern. Med. doi: 10.1001/archinte.160.18.2749 – ident: ref_118 doi: 10.3390/jcm9041208 – volume: 61 start-page: 1391 year: 2016 ident: ref_16 article-title: Scutellaria Baicalensis, the Golden Herb from the Garden of Chinese Medicinal Plants publication-title: Sci. Bull. doi: 10.1007/s11434-016-1136-5 – volume: 76 start-page: 689 year: 2008 ident: ref_20 article-title: Influence of Baicalin on Alveolar Bone Resorption in Rat Experimental Periodontitis publication-title: Sci. Pharm. doi: 10.3797/scipharm.0804-05 – volume: 25 start-page: 145 year: 1998 ident: ref_83 article-title: Molecular Size Distribution Analysis of Human Gingival Proteoglycans and Glycosaminoglycans in Specific Periodontal Diseases publication-title: J. Clin. Periodontol. doi: 10.1111/j.1600-051X.1998.tb02420.x – volume: 23 start-page: 2709 year: 2006 ident: ref_37 article-title: A Review of Poloxamer 407 Pharmaceutical and Pharmacological Characteristics publication-title: Pharm. Res. doi: 10.1007/s11095-006-9104-4 – volume: 91 start-page: 221 year: 2011 ident: ref_86 article-title: Hyaluronan as an Immune Regulator in Human Diseases publication-title: Physiol. Rev. doi: 10.1152/physrev.00052.2009
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Snippet	Scutellaria baicalensis root displays anti-inflammatory and antibacterial properties due to the presence of flavonoids, particularly baicalin, baicalein, and... root displays anti-inflammatory and antibacterial properties due to the presence of flavonoids, particularly baicalin, baicalein, and wogonin. Our work aimed...
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SubjectTerms	Animals Antibiotics Bacteria Biopolymers Cellulose Chitosan - administration & dosage Chitosan - pharmacology Chromatography Cytokines Dental plaque Disease Drugs, Chinese Herbal - pharmacology Flavanones - pharmacology Flavonoids Flavonoids - pharmacology Fourier transforms Gum disease Hydrogels Hydrogels - analysis Hydrogels - chemistry Hydrogels - pharmacology Kinases Ligaments Microorganisms Mouth Mucosa - drug effects Mouth Mucosa - metabolism Periodontal Diseases - drug therapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Roots Polymers Proteins Scutellaria baicalensis - metabolism Signal transduction Spectrum analysis Swine Viscosity
Title	Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of Scutellariae baicalensis radix Extract and Chitosan for Periodontal Diseases Treatment
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