Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of Scutellariae baicalensis radix Extract and Chitosan for Periodontal Diseases Treatment

Scutellaria baicalensis root displays anti-inflammatory and antibacterial properties due to the presence of flavonoids, particularly baicalin, baicalein, and wogonin. Our work aimed at developing thermosensitive hydrogels containing a binary mixture of S. baicalensis radix lyophilized extract and ch...

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Veröffentlicht in:International journal of molecular sciences Jg. 22; H. 21; S. 11319
Hauptverfasser: Chanaj-Kaczmarek, Justyna, Osmałek, Tomasz, Szymańska, Emilia, Winnicka, Katarzyna, Karpiński, Tomasz M., Dyba, Magdalena, Bekalarska-Dębek, Marta, Cielecka-Piontek, Judyta
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 20.10.2021
MDPI
Schlagworte:
Animals
Antibiotics
Bacteria
Biopolymers
Cellulose
Chitosan - administration & dosage
Chitosan - pharmacology
Chromatography
Cytokines
Dental plaque
Disease
Drugs, Chinese Herbal - pharmacology
Flavanones - pharmacology
Flavonoids
Flavonoids - pharmacology
Fourier transforms
Gum disease
Hydrogels
Hydrogels - analysis
Hydrogels - chemistry
Hydrogels - pharmacology
Kinases
Ligaments
Microorganisms
Mouth Mucosa - drug effects
Mouth Mucosa - metabolism
Periodontal Diseases - drug therapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Roots
Polymers
Proteins
Scutellaria baicalensis - metabolism
Signal transduction
Spectrum analysis
Swine
Viscosity
chitosan
dissolution studies
Scutellaria baicalensis
periodontal diseases
ex vivo mucoadhesion
permeability
ISSN:1422-0067, 1661-6596, 1422-0067
Online-Zugang:Volltext
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Zusammenfassung:Scutellaria baicalensis root displays anti-inflammatory and antibacterial properties due to the presence of flavonoids, particularly baicalin, baicalein, and wogonin. Our work aimed at developing thermosensitive hydrogels containing a binary mixture of S. baicalensis radix lyophilized extract and chitosan as a novel approach for periodontal diseases treatment. Two types of chitosan were employed in preliminary studies on binary mixtures with S. baicalensis radix lyophilized extract standardized for baicalin, baicalein, and wogonin. Thermosensitive hydrogels were prepared of poloxamer 407, alginate sodium, and cellulose derivatives and evaluated in terms of rheological and mucoadhesive behavior. The presence of chitosan altered the release profile of active compounds but did not affect their in vitro permeation behavior in PAMPA assay. The synergistic effects of S. baicalensis radix lyophilized extract and chitosan toward ferrous ion-chelating activity, inhibition of hyaluronidase, and pathogen growth were observed. The thermosensitive gelling system showed shear-thinning properties, gelation temperature between 25 and 27 °C, and favorable mucoadhesiveness in contact with porcine buccal mucosa, which was enhanced in the presence of binary mixture of S. baicalensis radix extract and chitosan. The release tests showed that baicalin and baicalein were liberated in a prolonged manner with a fast onset from hydrogel formulations.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms222111319