Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice

Despite decades of research, our understanding of the processes controlling late-stage atherosclerotic plaque stability remains poor. A prevailing hypothesis is that reducing inflammation may improve advanced plaque stability, as recently tested in the Canakinumab Anti-inflammatory Thrombosis Outcom...

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Bibliographic Details
Published in:	Nature medicine Vol. 24; no. 9; pp. 1418 - 1429
Main Authors:	Gomez, Delphine, Baylis, Richard A., Durgin, Brittany G., Newman, Alexandra A. C., Alencar, Gabriel F., Mahan, Sidney, St. Hilaire, Cynthia, Müller, Werner, Waisman, Ari, Francis, Sheila E., Pinteaux, Emmanuel, Randolph, Gwendalyn J., Gram, Hermann, Owens, Gary K.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.09.2018 Nature Publishing Group
Subjects:	631/80/304 692/420/256/2515 692/699/75/593/2100 Animals Antibodies Antibodies, Neutralizing - pharmacology Apolipoprotein E Apoptosis - drug effects Arteriosclerosis Atherosclerosis Atherosclerosis - metabolism Atherosclerosis - pathology Biomedical and Life Sciences Biomedicine Cancer Research Cell Polarity - drug effects Cell Proliferation - drug effects Collagen Control stability Down-Regulation - drug effects Immunoglobulin G Infectious Diseases Inflammation Inflammation - pathology Interleukin 1 Interleukin 1 receptors Interleukin-1beta - metabolism Lesions Macrophages Macrophages - drug effects Macrophages - metabolism Metabolic Diseases Mice Mice, Inbred C57BL Molecular Medicine Monocytes - drug effects Monocytes - metabolism Muscles Myocardial infarction Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Neurosciences Neutralization Tests Phenotype Signal Transduction - drug effects Smooth muscle Thromboembolism Thrombosis
ISSN:	1078-8956, 1546-170X, 1546-170X
Online Access:	Get full text
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