Febuxostat‐Induced Agranulocytosis: An Illustrative Case Report and Comprehensive Literature Review
ABSTRACT Neutropenia induced by febuxostat is uncommon, with limited literature available to assess its frequency. This rare complication carries a serious risk to life. It is essential for healthcare providers to stay alert and informed about this potential adverse reaction.
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| Vydáno v: | Clinical case reports Ročník 13; číslo 9; s. e70846 - n/a |
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John Wiley & Sons, Inc
01.09.2025
Wiley |
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| Abstract | ABSTRACT
Neutropenia induced by febuxostat is uncommon, with limited literature available to assess its frequency. This rare complication carries a serious risk to life. It is essential for healthcare providers to stay alert and informed about this potential adverse reaction. |
|---|---|
| AbstractList | ABSTRACT
Neutropenia induced by febuxostat is uncommon, with limited literature available to assess its frequency. This rare complication carries a serious risk to life. It is essential for healthcare providers to stay alert and informed about this potential adverse reaction. Neutropenia induced by febuxostat is uncommon, with limited literature available to assess its frequency. This rare complication carries a serious risk to life. It is essential for healthcare providers to stay alert and informed about this potential adverse reaction. ABSTRACT Neutropenia induced by febuxostat is uncommon, with limited literature available to assess its frequency. This rare complication carries a serious risk to life. It is essential for healthcare providers to stay alert and informed about this potential adverse reaction. Neutropenia induced by febuxostat is uncommon, with limited literature available to assess its frequency. This rare complication carries a serious risk to life. It is essential for healthcare providers to stay alert and informed about this potential adverse reaction.Neutropenia induced by febuxostat is uncommon, with limited literature available to assess its frequency. This rare complication carries a serious risk to life. It is essential for healthcare providers to stay alert and informed about this potential adverse reaction. |
| Author | Liu, Qiuping Zhong, Bing |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40948700$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1002/acr.24180 10.1186/s40360-023-00723-5 10.1111/jcpt.12057 10.1007/s00482-016-0160-3 10.1002/cpt.1377 10.21307/immunohematology-2019-103 10.1007/s40265-015-0360-7 10.1111/j.1600-0609.1996.tb01641.x 10.1097/MD.0000000000005863 10.1016/j.immuni.2021.06.006 |
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| References_xml | – volume: 106 start-page: 391 issue: 2 year: 2019 end-page: 401 article-title: Hypersensitivity and Cardiovascular Risks Related to Allopurinol and Febuxostat Therapy in Asians: A Population‐Based Cohort Study and Meta‐Analysis publication-title: Clinical Pharmacology and Therapeutics – volume: 38 start-page: 258 issue: 3 year: 2013 end-page: 261 article-title: Acute Neutropenia Associated With Initiation of Febuxostat Therapy for Hyperuricaemia in Patients With Chronic Kidney Disease publication-title: Journal of Clinical Pharmacy and Therapeutics – volume: 72 start-page: 744 year: 2020 end-page: 760 article-title: American College of Rheumatology Guideline for the Management of Gout publication-title: Arthritis Care & Research (Hoboken) – volume: 60 start-page: 23 year: 1996 end-page: 30 article-title: Drugs in the Aetiology of Agranulocytosis and Aplastic Anaemia[J] publication-title: European Journal of Haematology – volume: 4 start-page: 427 year: 2015 end-page: 438 article-title: Febuxostat: A Review of Its Use in the Treatment of Hyperuricaemia in Patients With Gout publication-title: Drugs – volume: 96 issue: 2 year: 2017 article-title: Febuxostat‐Induced Agranulocytosis in an End‐Stage Renal Disease Patient: A Case Report publication-title: Medicine – volume: 30 start-page: 95 issue: 2 year: 2014 end-page: 101 article-title: Drug‐Induced Immune Neutropenia/Agranulocytosis publication-title: Immunohematology – volume: 31 start-page: 5 year: 2017 end-page: 13 article-title: Dipyrone (Metamizole): Considerations on Monitoring for Early Detection of Agranulocytosis publication-title: Schmerz – volume: 54 start-page: 1377 year: 2021 end-page: 1391 article-title: The Neutrophil publication-title: Immunity – volume: 24 start-page: 79 issue: 1 year: 2023 article-title: Effectiveness and Safety of Different Doses of Febuxostat Compared With Allopurinol in the Treatment of Hyperuricemia: A Meta‐Analysis of Randomized Controlled Trials publication-title: BMC Pharmacology and Toxicology – ident: e_1_2_11_2_1 doi: 10.1002/acr.24180 – ident: e_1_2_11_4_1 doi: 10.1186/s40360-023-00723-5 – ident: e_1_2_11_7_1 doi: 10.1111/jcpt.12057 – ident: e_1_2_11_9_1 doi: 10.1007/s00482-016-0160-3 – ident: e_1_2_11_3_1 doi: 10.1002/cpt.1377 – ident: e_1_2_11_11_1 doi: 10.21307/immunohematology-2019-103 – ident: e_1_2_11_5_1 doi: 10.1007/s40265-015-0360-7 – ident: e_1_2_11_10_1 doi: 10.1111/j.1600-0609.1996.tb01641.x – ident: e_1_2_11_6_1 doi: 10.1097/MD.0000000000005863 – ident: e_1_2_11_8_1 doi: 10.1016/j.immuni.2021.06.006 |
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Neutropenia induced by febuxostat is uncommon, with limited literature available to assess its frequency. This rare complication carries a serious... Neutropenia induced by febuxostat is uncommon, with limited literature available to assess its frequency. This rare complication carries a serious risk to... ABSTRACT Neutropenia induced by febuxostat is uncommon, with limited literature available to assess its frequency. This rare complication carries a serious... |
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| SubjectTerms | adverse reaction Arthritis Biopsy Blood Blood diseases Bone marrow Case reports Drug dosages febuxostat granulocytosis Hospitals hyperuricemia Infections Leukocytes Literature reviews Liver Neutropenia Neutrophils Patients Rheumatism Uric acid Vital signs |
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| Title | Febuxostat‐Induced Agranulocytosis: An Illustrative Case Report and Comprehensive Literature Review |
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