Melatonin directly binds and inhibits death‐associated protein kinase 1 function in Alzheimer’s disease

Death‐associated protein kinase 1 (DAPK1) is upregulated in the brains of human Alzheimer's disease (AD) patients compared with normal subjects, and aberrant DAPK1 regulation is implicated in the development of AD. However, little is known about whether and how DAPK1 function is regulated in AD...

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Vydáno v:Journal of pineal research Ročník 69; číslo 2; s. e12665 - n/a
Hlavní autoři: Chen, Dongmei, Mei, Yingxue, Kim, Nami, Lan, Guihua, Gan, Chen‐Ling, Fan, Fei, Zhang, Tao, Xia, Yongfang, Wang, Long, Lin, Chun, Ke, Fang, Zhou, Xiao Zhen, Lu, Kun Ping, Lee, Tae Ho
Médium: Journal Article
Jazyk:angličtina
Vydáno: England 01.09.2020
Témata:
Alzheimer's disease
death‐associated protein kinase 1 (DAPK1)
melatonin
Pin1
tau
Pin1
tau
death-associated protein kinase 1 (DAPK1)
melatonin
Alzheimer's disease
ISSN:0742-3098, 1600-079X, 1600-079X
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Abstract Death‐associated protein kinase 1 (DAPK1) is upregulated in the brains of human Alzheimer's disease (AD) patients compared with normal subjects, and aberrant DAPK1 regulation is implicated in the development of AD. However, little is known about whether and how DAPK1 function is regulated in AD. Here, we identified melatonin as a critical regulator of DAPK1 levels and function. Melatonin significantly decreases DAPK1 expression in a post‐transcriptional manner in neuronal cell lines and mouse primary cortical neurons. Moreover, melatonin directly binds to DAPK1 and promotes its ubiquitination, resulting in increased DAPK1 protein degradation through a proteasome‐dependent pathway. Furthermore, in tau‐overexpressing mouse brain slices, melatonin treatment and the inhibition of DAPK1 kinase activity synergistically decrease tau phosphorylation at multiple sites related to AD. In addition, melatonin and DAPK1 inhibitor dramatically accelerate neurite outgrowth and increase the assembly of microtubules. Mechanistically, melatonin‐mediated DAPK1 degradation increases the activity of Pin1, a prolyl isomerase known to play a protective role against tau hyperphosphorylation and tau‐related pathologies. Finally, elevated DAPK1 expression shows a strong correlation with the decrease in melatonin levels in human AD brains. Combined, these results suggest that DAPK1 regulation by melatonin is a novel mechanism that controls tau phosphorylation and function and offers new therapeutic options for treating human AD.
AbstractList Death‐associated protein kinase 1 (DAPK1) is upregulated in the brains of human Alzheimer's disease (AD) patients compared with normal subjects, and aberrant DAPK1 regulation is implicated in the development of AD. However, little is known about whether and how DAPK1 function is regulated in AD. Here, we identified melatonin as a critical regulator of DAPK1 levels and function. Melatonin significantly decreases DAPK1 expression in a post‐transcriptional manner in neuronal cell lines and mouse primary cortical neurons. Moreover, melatonin directly binds to DAPK1 and promotes its ubiquitination, resulting in increased DAPK1 protein degradation through a proteasome‐dependent pathway. Furthermore, in tau‐overexpressing mouse brain slices, melatonin treatment and the inhibition of DAPK1 kinase activity synergistically decrease tau phosphorylation at multiple sites related to AD. In addition, melatonin and DAPK1 inhibitor dramatically accelerate neurite outgrowth and increase the assembly of microtubules. Mechanistically, melatonin‐mediated DAPK1 degradation increases the activity of Pin1, a prolyl isomerase known to play a protective role against tau hyperphosphorylation and tau‐related pathologies. Finally, elevated DAPK1 expression shows a strong correlation with the decrease in melatonin levels in human AD brains. Combined, these results suggest that DAPK1 regulation by melatonin is a novel mechanism that controls tau phosphorylation and function and offers new therapeutic options for treating human AD.
Death-associated protein kinase 1 (DAPK1) is upregulated in the brains of human Alzheimer's disease (AD) patients compared with normal subjects, and aberrant DAPK1 regulation is implicated in the development of AD. However, little is known about whether and how DAPK1 function is regulated in AD. Here, we identified melatonin as a critical regulator of DAPK1 levels and function. Melatonin significantly decreases DAPK1 expression in a post-transcriptional manner in neuronal cell lines and mouse primary cortical neurons. Moreover, melatonin directly binds to DAPK1 and promotes its ubiquitination, resulting in increased DAPK1 protein degradation through a proteasome-dependent pathway. Furthermore, in tau-overexpressing mouse brain slices, melatonin treatment and the inhibition of DAPK1 kinase activity synergistically decrease tau phosphorylation at multiple sites related to AD. In addition, melatonin and DAPK1 inhibitor dramatically accelerate neurite outgrowth and increase the assembly of microtubules. Mechanistically, melatonin-mediated DAPK1 degradation increases the activity of Pin1, a prolyl isomerase known to play a protective role against tau hyperphosphorylation and tau-related pathologies. Finally, elevated DAPK1 expression shows a strong correlation with the decrease in melatonin levels in human AD brains. Combined, these results suggest that DAPK1 regulation by melatonin is a novel mechanism that controls tau phosphorylation and function and offers new therapeutic options for treating human AD.
Death-associated protein kinase 1 (DAPK1) is upregulated in the brains of human Alzheimer's disease (AD) patients compared with normal subjects, and aberrant DAPK1 regulation is implicated in the development of AD. However, little is known about whether and how DAPK1 function is regulated in AD. Here, we identified melatonin as a critical regulator of DAPK1 levels and function. Melatonin significantly decreases DAPK1 expression in a post-transcriptional manner in neuronal cell lines and mouse primary cortical neurons. Moreover, melatonin directly binds to DAPK1 and promotes its ubiquitination, resulting in increased DAPK1 protein degradation through a proteasome-dependent pathway. Furthermore, in tau-overexpressing mouse brain slices, melatonin treatment and the inhibition of DAPK1 kinase activity synergistically decrease tau phosphorylation at multiple sites related to AD. In addition, melatonin and DAPK1 inhibitor dramatically accelerate neurite outgrowth and increase the assembly of microtubules. Mechanistically, melatonin-mediated DAPK1 degradation increases the activity of Pin1, a prolyl isomerase known to play a protective role against tau hyperphosphorylation and tau-related pathologies. Finally, elevated DAPK1 expression shows a strong correlation with the decrease in melatonin levels in human AD brains. Combined, these results suggest that DAPK1 regulation by melatonin is a novel mechanism that controls tau phosphorylation and function and offers new therapeutic options for treating human AD.Death-associated protein kinase 1 (DAPK1) is upregulated in the brains of human Alzheimer's disease (AD) patients compared with normal subjects, and aberrant DAPK1 regulation is implicated in the development of AD. However, little is known about whether and how DAPK1 function is regulated in AD. Here, we identified melatonin as a critical regulator of DAPK1 levels and function. Melatonin significantly decreases DAPK1 expression in a post-transcriptional manner in neuronal cell lines and mouse primary cortical neurons. Moreover, melatonin directly binds to DAPK1 and promotes its ubiquitination, resulting in increased DAPK1 protein degradation through a proteasome-dependent pathway. Furthermore, in tau-overexpressing mouse brain slices, melatonin treatment and the inhibition of DAPK1 kinase activity synergistically decrease tau phosphorylation at multiple sites related to AD. In addition, melatonin and DAPK1 inhibitor dramatically accelerate neurite outgrowth and increase the assembly of microtubules. Mechanistically, melatonin-mediated DAPK1 degradation increases the activity of Pin1, a prolyl isomerase known to play a protective role against tau hyperphosphorylation and tau-related pathologies. Finally, elevated DAPK1 expression shows a strong correlation with the decrease in melatonin levels in human AD brains. Combined, these results suggest that DAPK1 regulation by melatonin is a novel mechanism that controls tau phosphorylation and function and offers new therapeutic options for treating human AD.
Author Lan, Guihua
Ke, Fang
Gan, Chen‐Ling
Xia, Yongfang
Wang, Long
Lin, Chun
Lu, Kun Ping
Lee, Tae Ho
Chen, Dongmei
Fan, Fei
Mei, Yingxue
Kim, Nami
Zhang, Tao
Zhou, Xiao Zhen
AuthorAffiliation 5 Fujian Health College, Fuzhou, Fujian, China
1 Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, China
2 Division of Translational Therapeutics, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
4 Fujian Provincial Key Laboratory of Neuroglia and Diseases, Laboratory of Pain Research, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, China
3 Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, Institute of Materia Medica, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China
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– name: 5 Fujian Health College, Fuzhou, Fujian, China
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/32358852$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1083/jcb.101.5.1799
10.1111/j.0953-816X.2004.03365.x
10.1111/j.1600-079X.2004.00136.x
10.1523/JNEUROSCI.2258-16.2016
10.1111/j.1600-079X.2011.00864.x
10.1038/nature01832
10.3233/JAD-170900
10.1038/emboj.2010.62
10.1210/jc.2003-030833
10.1074/jbc.M208585200
10.1016/j.bbadis.2004.06.017
10.1016/j.arr.2012.06.003
10.1034/j.1600-079X.2003.00065.x
10.1111/j.1600-079X.2004.00130.x
10.1016/j.cell.2009.12.055
10.1016/S0169-328X(00)00245-X
10.3390/ijms20133131
10.1007/s10495-013-0936-1
10.3233/JAD-130377
10.1074/jbc.M605097200
10.1111/j.1600-079X.2004.00116.x
10.1242/jcs.107.4.869
10.1111/j.1600-079X.2011.00937.x
10.1097/00001756-199908020-00035
10.1016/0006-8993(90)90214-V
10.1038/nrn3712
10.1093/hmg/ddl178
10.1016/j.tins.2008.11.007
10.1146/annurev.biochem.75.103004.142615
10.1016/S0531-5565(00)00160-1
10.1358/dnp.2006.19.8.1043961
10.1016/j.biopha.2006.01.002
10.1038/cdd.2016.114
10.1093/cercor/bhv096
10.1111/jpi.12578
10.1523/JNEUROSCI.1065-09.2009
10.3233/JAD-2009-0949
10.1002/1873-3468.13218
10.1111/j.1600-079X.2004.00196.x
10.1016/0006-8993(96)00086-8
10.1016/S0006-3223(97)00510-6
10.1038/cddis.2014.216
10.1111/jpi.12618
10.1016/0014-5793(94)00650-4
10.1016/0896-6273(93)90057-X
10.1034/j.1600-079X.2003.00034.x
10.1016/j.pneurobio.2008.04.001
10.2174/1570159X15666170313123454
10.1016/j.molcel.2011.03.005
10.1126/science.1132813
10.1111/j.1365-2990.2006.00795.x
10.1111/jpi.12238
10.1007/s10495-013-0917-4
10.1038/21650
10.1046/j.1471-4159.2003.01879.x
10.1111/j.1600-079X.2006.00343.x
10.1038/nrn2194
10.1242/jcs.01558
10.3390/ijms140714575
10.1046/j.1432-1033.2003.03430.x
10.1007/s12035-019-01660-3
10.1001/archneurol.2007.3
10.1046/j.1471-4159.1999.0722053.x
10.1074/jbc.M610430200
10.4049/jimmunol.0801892
10.1016/j.bbagen.2019.129467
10.1016/j.arr.2012.04.003
10.1111/jpi.12470
10.1007/s10495-013-0924-5
10.1016/S0896-6273(00)00147-1
10.1017/S1462399411001906
10.1016/0896-6273(89)90050-0
10.1002/(SICI)1097-4547(19991201)58:5<674::AID-JNR8>3.0.CO;2-3
10.1038/cdd.2011.2
10.1021/jm901191q
10.1074/jbc.M505804200
10.2174/1574892814666181218170257
10.1016/S0169-328X(02)00488-6
10.1016/S0166-2236(98)01337-X
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ISSN 0742-3098
1600-079X
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Issue 2
Keywords Pin1
tau
death-associated protein kinase 1 (DAPK1)
melatonin
Alzheimer's disease
Language English
License 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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Notes Dongmei Chen and Yingxue Mei contributed equally to this work.
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SourceType-Scholarly Journals-1
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content type line 23
DC designed the studies, analyzed the data, and wrote the manuscript. DC and YM performed most of experiments. NK performed qPCR and in vitro kinase assay, and edited the manuscript. GL performed immunohistochemical analysis and edited the manuscript. FF and CL helped with brain slice experiments and edited the manuscript. C.-LG and FK helped with biotin-melatonin experiments and edited the manuscript. TZ provided advice and edited the manuscript. YX and LW provided advice and technical assistance. XZZ and KPL provided human specimens and wrote the manuscript. THL conceived and supervised the project, designed the studies, and wrote the manuscript.
AUTHOR CONTRIBUTIONS
ORCID 0000-0001-5968-1478
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/7890046
PMID 32358852
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PublicationCentury 2000
PublicationDate September 2020
PublicationDateYYYYMMDD 2020-09-01
PublicationDate_xml – month: 09
  year: 2020
  text: September 2020
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Journal of pineal research
PublicationTitleAlternate J Pineal Res
PublicationYear 2020
References 2006; 75
2019; 56
2000; 85
2019; 14
2002; 277
1999; 45
2003; 270
2011; 13
2010; 140
1999; 84
2007; 33
2011; 18
2016; 36
2012; 52
2006; 60
2014; 5
2009; 52
2013; 14
2019; 20
2010; 29
2013; 12
2004; 36
2019; 67
2004; 37
1999; 58
2007; 8
2014; 15
2008; 118
1999; 10
2008; 65
2014; 19
2006; 281
2002; 109
1996; 4
2005; 38
1994; 107
1994; 349
2009; 16
2020; 1864
2003; 86
2003; 88
2010; 34
2015; 57
1989; 2
1990; 528
2015; 59
2005; 1739
2000; 28
2007; 282
2006; 17
2017; 24
2006; 15
2003; 35
1985; 101
2006; 19
2018; 62
2006; 314
1998; 21
2018; 64
2009; 29
1996; 717
2018; 592
2005; 280
2015; 25
2006; 41
2013; 37
2009; 32
2003; 424
2017; 15
2004; 19
2000; 35
1993; 10
2011; 51
2011; 42
2009; 183
2020; 68
1999; 399
2008; 85
1999; 72
2004; 117
2016; 25
e_1_2_7_3_1
e_1_2_7_9_1
e_1_2_7_7_1
e_1_2_7_19_1
e_1_2_7_60_1
e_1_2_7_83_1
e_1_2_7_17_1
e_1_2_7_62_1
e_1_2_7_81_1
e_1_2_7_15_1
e_1_2_7_41_1
e_1_2_7_64_1
e_1_2_7_13_1
e_1_2_7_43_1
e_1_2_7_85_1
e_1_2_7_11_1
e_1_2_7_45_1
e_1_2_7_68_1
e_1_2_7_47_1
e_1_2_7_26_1
e_1_2_7_49_1
e_1_2_7_28_1
Mandell JW (e_1_2_7_67_1) 1996; 4
e_1_2_7_73_1
Kim BM (e_1_2_7_37_1) 2016; 25
e_1_2_7_50_1
e_1_2_7_71_1
e_1_2_7_25_1
e_1_2_7_31_1
e_1_2_7_52_1
e_1_2_7_77_1
e_1_2_7_23_1
e_1_2_7_33_1
e_1_2_7_54_1
e_1_2_7_75_1
e_1_2_7_21_1
e_1_2_7_35_1
e_1_2_7_56_1
Yukawa K (e_1_2_7_34_1) 2006; 17
e_1_2_7_58_1
e_1_2_7_79_1
e_1_2_7_39_1
Silvia C (e_1_2_7_5_1) 2015; 57
e_1_2_7_6_1
e_1_2_7_4_1
e_1_2_7_80_1
e_1_2_7_8_1
e_1_2_7_18_1
e_1_2_7_84_1
e_1_2_7_16_1
e_1_2_7_40_1
e_1_2_7_61_1
e_1_2_7_82_1
e_1_2_7_2_1
e_1_2_7_14_1
e_1_2_7_42_1
e_1_2_7_63_1
e_1_2_7_12_1
e_1_2_7_65_1
e_1_2_7_86_1
e_1_2_7_10_1
e_1_2_7_46_1
e_1_2_7_48_1
e_1_2_7_69_1
e_1_2_7_27_1
e_1_2_7_29_1
Esmaeli‐Azad B (e_1_2_7_66_1) 1994; 107
Lim J (e_1_2_7_44_1) 2008; 118
e_1_2_7_51_1
e_1_2_7_70_1
e_1_2_7_30_1
e_1_2_7_53_1
e_1_2_7_76_1
e_1_2_7_24_1
e_1_2_7_32_1
e_1_2_7_55_1
e_1_2_7_74_1
e_1_2_7_22_1
e_1_2_7_57_1
Liu RY (e_1_2_7_72_1) 1999; 84
e_1_2_7_20_1
e_1_2_7_36_1
e_1_2_7_59_1
e_1_2_7_78_1
e_1_2_7_38_1
References_xml – volume: 35
  start-page: 125
  issue: 2
  year: 2003
  end-page: 130
  article-title: Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels
  publication-title: J Pineal Res
– volume: 51
  start-page: 75
  issue: 1
  year: 2011
  end-page: 86
  article-title: Melatonin treatment restores mitochondrial function in Alzheimer's mice: a mitochondrial protective role of melatonin membrane receptor signaling
  publication-title: J Pineal Res
– volume: 10
  start-page: 1089
  issue: 6
  year: 1993
  end-page: 1099
  article-title: Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding
  publication-title: Neuron
– volume: 1864
  start-page: 129467
  year: 2020
  article-title: Melatonin interacts with repeat domain of Tau to mediate disaggregation of paired helical filaments
  publication-title: Biochim Biophys Acta Gen Subj
– volume: 72
  start-page: 2053
  issue: 5
  year: 1999
  end-page: 2058
  article-title: p38 kinase is activated in the Alzheimer's disease brain
  publication-title: J Neurochem
– volume: 68
  year: 2020
  article-title: Identification of a novel melatonin‐binding nuclear receptor: vitamin D receptor
  publication-title: J Pineal Res
– volume: 281
  start-page: 39033
  issue: 51
  year: 2006
  end-page: 39040
  article-title: Control of death‐associated protein kinase (DAPK) activity by phosphorylation and proteasomal degradation
  publication-title: J Biol Chem
– volume: 101
  start-page: 1799
  issue: 5 Pt 1
  year: 1985
  end-page: 1807
  article-title: Nerve growth factor‐induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly‐promoting factors
  publication-title: J Cell Biol
– volume: 349
  start-page: 104
  issue: 1
  year: 1994
  end-page: 108
  article-title: Grundke‐Iqbal I. Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation
  publication-title: FEBS Lett
– volume: 18
  start-page: 1507
  issue: 9
  year: 2011
  end-page: 1520
  article-title: DAPK activates MARK1/2 to regulate microtubule assembly, neuronal differentiation, and tau toxicity
  publication-title: Cell Death Differ
– volume: 52
  start-page: 167
  issue: 2
  year: 2012
  end-page: 202
  article-title: Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin
  publication-title: J Pineal Res
– volume: 45
  start-page: 417
  issue: 4
  year: 1999
  end-page: 421
  article-title: Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer's type with disturbed sleep‐waking
  publication-title: Biol Psychiatry
– volume: 36
  start-page: 186
  issue: 3
  year: 2004
  end-page: 191
  article-title: Melatonin protects SH‐SY5Y neuroblastoma cells from calyculin A‐induced neurofilament impairment and neurotoxicity
  publication-title: J Pineal Res
– volume: 5
  year: 2014
  article-title: Death‐associated protein kinase 1 has a critical role in aberrant tau protein regulation and function
  publication-title: Cell Death Dis
– volume: 35
  start-page: 1239
  issue: 9–10
  year: 2000
  end-page: 1250
  article-title: Pineal and pituitary‐adrenocortical function in physiological aging and in senile dementia
  publication-title: Exp Gerontol
– volume: 12
  start-page: 188
  issue: 1
  year: 2013
  end-page: 200
  article-title: Reciprocal interactions between sleep, circadian rhythms and Alzheimer's disease: Focus on the role of hypocretin and melatonin
  publication-title: Ageing Res Rev
– volume: 29
  start-page: 10741
  issue: 34
  year: 2009
  end-page: 10749
  article-title: Age‐dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology
  publication-title: J Neurosci
– volume: 36
  start-page: 10843
  issue: 42
  year: 2016
  end-page: 10852
  article-title: Selective degeneration of entorhinal‐CA1 synapses in Alzheimer's disease via activation of DAPK1
  publication-title: J Neurosci
– volume: 399
  start-page: 784
  issue: 6738
  year: 1999
  end-page: 788
  article-title: The prolyl isomerase Pin1 restores the function of Alzheimer‐associated phosphorylated tau protein
  publication-title: Nature
– volume: 37
  start-page: 71
  issue: 2
  year: 2004
  end-page: 77
  article-title: Effect of inhibiting melatonin biosynthesis on spatial memory retention and tau phosphorylation in rat
  publication-title: J Pineal Res
– volume: 24
  start-page: 238
  issue: 2
  year: 2017
  end-page: 250
  article-title: Death‐associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death
  publication-title: Cell Death Differ
– volume: 282
  start-page: 11795
  issue: 16
  year: 2007
  end-page: 11804
  article-title: Regulation of death‐associated protein kinase. Stabilization by HSP90 heterocomplexes
  publication-title: J Biol Chem
– volume: 14
  start-page: 144
  issue: 2
  year: 2019
  end-page: 157
  article-title: Death‐associated protein kinase 1 as a promising drug target in cancer and Alzheimer's disease
  publication-title: Recent Pat Anticancer Drug Discov
– volume: 86
  start-page: 582
  issue: 3
  year: 2003
  end-page: 590
  article-title: Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
  publication-title: J Neurochem
– volume: 88
  start-page: 5898
  issue: 12
  year: 2003
  end-page: 5906
  article-title: Molecular changes underlying reduced pineal melatonin levels in Alzheimer disease: alterations in preclinical and clinical stages
  publication-title: J Clin Endocrinol Metab
– volume: 10
  start-page: 2411
  issue: 11
  year: 1999
  end-page: 2415
  article-title: Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation
  publication-title: NeuroReport
– volume: 41
  start-page: 124
  issue: 2
  year: 2006
  end-page: 129
  article-title: Melatonin arrests peroxynitrite‐induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain
  publication-title: J Pineal Res
– volume: 19
  start-page: 306
  issue: 2
  year: 2014
  end-page: 315
  article-title: Post‐translational regulation of the cellular levels of DAPK
  publication-title: Apoptosis
– volume: 67
  issue: 1
  year: 2019
  article-title: Pharmacological doses of melatonin impede cognitive decline in tau‐related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux
  publication-title: J Pineal Res
– volume: 183
  start-page: 2068
  issue: 3
  year: 2009
  end-page: 2078
  article-title: TNF‐alpha preconditioning protects neurons via neuron‐specific up‐regulation of CREB‐binding protein
  publication-title: J Immunol
– volume: 60
  start-page: 97
  issue: 3
  year: 2006
  end-page: 108
  article-title: Melatonin receptors in humans: biological role and clinical relevance
  publication-title: Biomed Pharmacother
– volume: 4
  start-page: 125
  issue: 2–3
  year: 1996
  end-page: 135
  article-title: Microtubule‐associated proteins, phosphorylation gradients, and the establishment of neuronal polarity
  publication-title: Perspect Dev Neurobiol
– volume: 34
  start-page: 153
  issue: 3
  year: 2010
  end-page: 160
  article-title: The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion
  publication-title: J Pineal Res
– volume: 19
  start-page: 286
  issue: 2
  year: 2014
  end-page: 297
  article-title: The DAPK family: a structure‐function analysis
  publication-title: Apoptosis
– volume: 2
  start-page: 1615
  issue: 6
  year: 1989
  end-page: 1624
  article-title: The microtubule binding domain of tau protein
  publication-title: Neuron
– volume: 14
  start-page: 14575
  issue: 7
  year: 2013
  end-page: 14593
  article-title: Melatonin in Alzheimer's disease
  publication-title: Int J Mol Sci
– volume: 25
  start-page: 2498
  issue: 12
  year: 2016
  end-page: 2513
  article-title: Inhibition of death‐associated protein kinase 1 attenuates the phosphorylation and amyloidogenic processing of amyloid precursor protein
  publication-title: Hum Mol Genet
– volume: 19
  start-page: 339
  issue: 2
  year: 2014
  end-page: 345
  article-title: Role of DAPK in neuronal cell death
  publication-title: Apoptosis
– volume: 25
  start-page: 4559
  issue: 11
  year: 2015
  end-page: 4571
  article-title: A novel mechanism of spine damages in stroke via DAPK1 and tau
  publication-title: Cereb Cortex
– volume: 13
  year: 2011
  article-title: Peptidyl‐prolyl cis‐trans isomerase Pin1 in ageing, cancer and Alzheimer disease
  publication-title: Expert Rev Mol Med
– volume: 52
  start-page: 7323
  issue: 22
  year: 2009
  end-page: 7327
  article-title: Identification of death‐associated protein kinases inhibitors using structure‐based virtual screening
  publication-title: J Med Chem
– volume: 12
  start-page: 289
  issue: 1
  year: 2013
  end-page: 309
  article-title: Tau protein kinases: involvement in Alzheimer's disease
  publication-title: Ageing Res Rev
– volume: 19
  start-page: 2711
  issue: 10
  year: 2004
  end-page: 2719
  article-title: Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain
  publication-title: Eur J Neurosci
– volume: 15
  start-page: 206
  issue: 4
  year: 2014
  end-page: 206
  article-title: Circadian rhythms: Methylation mediates clock plasticity
  publication-title: Nat Rev Neurosci
– volume: 57
  start-page: 192
  issue: 2
  year: 2015
  end-page: 199
  article-title: Melatonin reduces endoplasmic reticulum stress and preserves sirtuin 1 expression in neuronal cells of newborn rats after hypoxia‐ischemia
  publication-title: J Pineal Res
– volume: 85
  start-page: 221
  issue: 1–2
  year: 2000
  end-page: 233
  article-title: JNK activation is associated with intracellular beta‐amyloid accumulation
  publication-title: Brain Res Mol Brain Res
– volume: 8
  start-page: 663
  issue: 9
  year: 2007
  end-page: 672
  article-title: Tau‐mediated neurodegeneration in Alzheimer's disease and related disorders
  publication-title: Nat Rev Neurosci
– volume: 140
  start-page: 222
  issue: 2
  year: 2010
  end-page: 234
  article-title: DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke
  publication-title: Cell
– volume: 38
  start-page: 145
  issue: 3
  year: 2005
  end-page: 152
  article-title: The human pineal gland and melatonin in aging and Alzheimer's disease
  publication-title: J Pineal Res
– volume: 280
  start-page: 42290
  issue: 51
  year: 2005
  end-page: 42299
  article-title: Death‐associated protein kinase is activated by dephosphorylation in response to cerebral ischemia
  publication-title: J Biol Chem
– volume: 717
  start-page: 154
  issue: 1–2
  year: 1996
  end-page: 159
  article-title: Daily rhythm of serum melatonin in patients with dementia of the degenerate type
  publication-title: Brain Res
– volume: 64
  issue: 4
  year: 2018
  article-title: Melatonin ameliorates Abeta42 ‐induced alteration of betaAPP‐processing secretases via the melatonin receptor through the Pin1/GSK3beta/NF‐kappaB pathway in SH‐SY5Y cells
  publication-title: J Pineal Res
– volume: 592
  start-page: 3082
  issue: 18
  year: 2018
  end-page: 3091
  article-title: The trans isomer of Tau peptide is prone to aggregate, and the WW domain of Pin1 drastically decreases its aggregation
  publication-title: FEBS Lett
– volume: 118
  start-page: 1877
  issue: 5
  year: 2008
  end-page: 1889
  article-title: Pin1 has opposite effects on wild‐type and P301L tau stability and tauopathy
  publication-title: J Clin Investig
– volume: 56
  start-page: 8255
  issue: 12
  year: 2019
  end-page: 8276
  article-title: Melatonin in Alzheimer's disease: a latent endogenous regulator of neurogenesis to mitigate alzheimer's neuropathology
  publication-title: Mol Neurobiol
– volume: 424
  start-page: 556
  issue: 6948
  year: 2003
  end-page: 561
  article-title: Role of the prolyl isomerase Pin1 in protecting against age‐dependent neurodegeneration
  publication-title: Nature
– volume: 65
  start-page: 45
  issue: 1
  year: 2008
  end-page: 53
  article-title: Candidate single‐nucleotide polymorphisms from a genomewide association study of Alzheimer disease
  publication-title: Arch Neurol
– volume: 85
  start-page: 335
  issue: 3
  year: 2008
  end-page: 353
  article-title: Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways
  publication-title: Prog Neurogibol
– volume: 117
  start-page: 5721
  issue: Pt 24
  year: 2004
  end-page: 5729
  article-title: Tau phosphorylation in neuronal cell function and dysfunction
  publication-title: J Cell Sci
– volume: 42
  start-page: 147
  issue: 2
  year: 2011
  end-page: 159
  article-title: Death‐associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function
  publication-title: Mol Cell
– volume: 84
  start-page: 323
  issue: 1
  year: 1999
  end-page: 327
  article-title: Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E‐epsilon4/4 genotype
  publication-title: J Clin Endocrinol Metab
– volume: 15
  start-page: 1010
  issue: 7
  year: 2017
  end-page: 1031
  article-title: Mechanisms of Melatonin in Alleviating Alzheimer's Disease
  publication-title: Curr Neuropharmacol
– volume: 17
  start-page: 869
  issue: 5
  year: 2006
  end-page: 873
  article-title: Deletion of the kinase domain from death‐associated protein kinase enhances spatial memory in mice
  publication-title: Int J Mol Med
– volume: 1739
  start-page: 280
  issue: 2–3
  year: 2005
  end-page: 297
  article-title: Tau phosphorylation: physiological and pathological consequences
  publication-title: Biochem Biophys Acta
– volume: 19
  start-page: 453
  issue: 8
  year: 2006
  end-page: 460
  article-title: The role of CDK5/P25 formation/inhibition in neurodegeneration
  publication-title: Drug News Perspect
– volume: 62
  start-page: 1481
  issue: 4
  year: 2018
  end-page: 1493
  article-title: Multi‐Faceted Role of Melatonin in Neuroprotection and Amelioration of Tau Aggregates in Alzheimer's Disease
  publication-title: Journal of Alzheimer's disease : JAD
– volume: 37
  start-page: 11
  issue: 1
  year: 2004
  end-page: 16
  article-title: Melatonin attenuates isoproterenol‐induced protein kinase A overactivation and tau hyperphosphorylation in rat brain
  publication-title: J Pineal Res
– volume: 75
  start-page: 189
  year: 2006
  end-page: 210
  article-title: The death‐associated protein kinases: structure, function, and beyond
  publication-title: Annu Rev Biochem
– volume: 528
  start-page: 170
  issue: 1
  year: 1990
  end-page: 174
  article-title: Daily variation in the concentration of melatonin and 5‐methoxytryptophol in the human pineal gland: effect of age and Alzheimer's disease
  publication-title: Brain Res
– volume: 109
  start-page: 45
  issue: 1–2
  year: 2002
  end-page: 55
  article-title: Up‐regulation of mitogen‐activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease
  publication-title: Brain Res Mol Brain Res
– volume: 15
  start-page: 2560
  issue: 17
  year: 2006
  end-page: 2568
  article-title: DAPK1 variants are associated with Alzheimer's disease and allele‐specific expression
  publication-title: Hum Mol Genet
– volume: 107
  start-page: 869
  issue: Pt 4
  year: 1994
  end-page: 879
  article-title: Sense and antisense transfection analysis of tau function: tau influences net microtubule assembly, neurite outgrowth and neuritic stability
  publication-title: J Cell Sci
– volume: 58
  start-page: 674
  issue: 5
  year: 1999
  end-page: 683
  article-title: Developmental changes in distribution of death‐associated protein kinase mRNAs
  publication-title: J Neurosci Res
– volume: 28
  start-page: 697
  issue: 3
  year: 2000
  end-page: 711
  article-title: NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein
  publication-title: Neuron
– volume: 33
  start-page: 43
  issue: 1
  year: 2007
  end-page: 55
  article-title: Increased level of active GSK‐3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration
  publication-title: Neuropathol Appl Neurobiol
– volume: 16
  start-page: 287
  issue: 2
  year: 2009
  end-page: 300
  article-title: Constant illumination induces Alzheimer‐like damages with endoplasmic reticulum involvement and the protection of melatonin
  publication-title: J Alzheimer's Dis
– volume: 37
  start-page: 795
  issue: 4
  year: 2013
  end-page: 808
  article-title: Phosphorylation of tau by death‐associated protein kinase 1 antagonizes the kinase‐induced cell apoptosis
  publication-title: J Alzheimer's Dis
– volume: 314
  start-page: 781
  issue: 5800
  year: 2006
  end-page: 784
  article-title: 100 years and counting: prospects for defeating Alzheimer's disease
  publication-title: Science (New York, NY)
– volume: 29
  start-page: 1748
  issue: 10
  year: 2010
  end-page: 1761
  article-title: The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses
  publication-title: EMBO J
– volume: 270
  start-page: 832
  issue: 5
  year: 2003
  end-page: 840
  article-title: An unexpected relationship
  publication-title: Eur J Biochem
– volume: 21
  start-page: 428
  issue: 10
  year: 1998
  end-page: 433
  article-title: Tau protein pathology in neurodegenerative diseases
  publication-title: Trends Neurosci
– volume: 32
  start-page: 150
  issue: 3
  year: 2009
  end-page: 159
  article-title: Tau pathophysiology in neurodegeneration: a tangled issue
  publication-title: Trends Neurosci
– volume: 20
  start-page: 3131
  issue: 13
  year: 2019
  article-title: Death‐associated protein kinase 1 phosphorylation in neuronal cell death and neurodegenerative disease
  publication-title: Int J Mol Sci
– volume: 277
  start-page: 46980
  issue: 49
  year: 2002
  end-page: 46986
  article-title: A death‐associated protein kinase (DAPK)‐interacting protein, DIP‐1, is an E3 ubiquitin ligase that promotes tumor necrosis factor‐induced apoptosis and regulates the cellular levels of DAPK
  publication-title: J Biol Chem
– volume: 59
  start-page: 47
  issue: 1
  year: 2015
  end-page: 59
  article-title: Melatonin ameliorates amyloid beta‐induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus
  publication-title: J Pineal Res
– ident: e_1_2_7_64_1
  doi: 10.1083/jcb.101.5.1799
– ident: e_1_2_7_85_1
  doi: 10.1111/j.0953-816X.2004.03365.x
– ident: e_1_2_7_22_1
  doi: 10.1111/j.1600-079X.2004.00136.x
– ident: e_1_2_7_35_1
  doi: 10.1523/JNEUROSCI.2258-16.2016
– ident: e_1_2_7_6_1
  doi: 10.1111/j.1600-079X.2011.00864.x
– ident: e_1_2_7_59_1
  doi: 10.1038/nature01832
– volume: 84
  start-page: 323
  issue: 1
  year: 1999
  ident: e_1_2_7_72_1
  article-title: Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E‐epsilon4/4 genotype
  publication-title: J Clin Endocrinol Metab
– ident: e_1_2_7_15_1
  doi: 10.3233/JAD-170900
– ident: e_1_2_7_47_1
  doi: 10.1038/emboj.2010.62
– ident: e_1_2_7_76_1
  doi: 10.1210/jc.2003-030833
– ident: e_1_2_7_46_1
  doi: 10.1074/jbc.M208585200
– ident: e_1_2_7_71_1
  doi: 10.1016/j.bbadis.2004.06.017
– ident: e_1_2_7_78_1
  doi: 10.1016/j.arr.2012.06.003
– ident: e_1_2_7_12_1
  doi: 10.1034/j.1600-079X.2003.00065.x
– ident: e_1_2_7_19_1
  doi: 10.1111/j.1600-079X.2004.00130.x
– ident: e_1_2_7_29_1
  doi: 10.1016/j.cell.2009.12.055
– ident: e_1_2_7_83_1
  doi: 10.1016/S0169-328X(00)00245-X
– ident: e_1_2_7_28_1
  doi: 10.3390/ijms20133131
– ident: e_1_2_7_50_1
  doi: 10.1007/s10495-013-0936-1
– ident: e_1_2_7_40_1
  doi: 10.3233/JAD-130377
– ident: e_1_2_7_49_1
  doi: 10.1074/jbc.M605097200
– ident: e_1_2_7_21_1
  doi: 10.1111/j.1600-079X.2004.00116.x
– volume: 107
  start-page: 869
  issue: 4
  year: 1994
  ident: e_1_2_7_66_1
  article-title: Sense and antisense transfection analysis of tau function: tau influences net microtubule assembly, neurite outgrowth and neuritic stability
  publication-title: J Cell Sci
  doi: 10.1242/jcs.107.4.869
– ident: e_1_2_7_7_1
  doi: 10.1111/j.1600-079X.2011.00937.x
– ident: e_1_2_7_82_1
  doi: 10.1097/00001756-199908020-00035
– ident: e_1_2_7_73_1
  doi: 10.1016/0006-8993(90)90214-V
– ident: e_1_2_7_3_1
  doi: 10.1038/nrn3712
– ident: e_1_2_7_32_1
  doi: 10.1093/hmg/ddl178
– ident: e_1_2_7_57_1
  doi: 10.1016/j.tins.2008.11.007
– ident: e_1_2_7_25_1
  doi: 10.1146/annurev.biochem.75.103004.142615
– ident: e_1_2_7_75_1
  doi: 10.1016/S0531-5565(00)00160-1
– ident: e_1_2_7_80_1
  doi: 10.1358/dnp.2006.19.8.1043961
– ident: e_1_2_7_52_1
  doi: 10.1016/j.biopha.2006.01.002
– ident: e_1_2_7_38_1
  doi: 10.1038/cdd.2016.114
– ident: e_1_2_7_41_1
  doi: 10.1093/cercor/bhv096
– ident: e_1_2_7_18_1
  doi: 10.1111/jpi.12578
– ident: e_1_2_7_63_1
  doi: 10.1523/JNEUROSCI.1065-09.2009
– ident: e_1_2_7_23_1
  doi: 10.3233/JAD-2009-0949
– ident: e_1_2_7_61_1
  doi: 10.1002/1873-3468.13218
– ident: e_1_2_7_11_1
  doi: 10.1111/j.1600-079X.2004.00196.x
– ident: e_1_2_7_74_1
  doi: 10.1016/0006-8993(96)00086-8
– volume: 57
  start-page: 192
  issue: 2
  year: 2015
  ident: e_1_2_7_5_1
  article-title: Melatonin reduces endoplasmic reticulum stress and preserves sirtuin 1 expression in neuronal cells of newborn rats after hypoxia‐ischemia
  publication-title: J Pineal Res
– ident: e_1_2_7_13_1
  doi: 10.1016/S0006-3223(97)00510-6
– ident: e_1_2_7_36_1
  doi: 10.1038/cddis.2014.216
– ident: e_1_2_7_54_1
  doi: 10.1111/jpi.12618
– ident: e_1_2_7_70_1
  doi: 10.1016/0014-5793(94)00650-4
– ident: e_1_2_7_69_1
  doi: 10.1016/0896-6273(93)90057-X
– ident: e_1_2_7_4_1
  doi: 10.1034/j.1600-079X.2003.00034.x
– ident: e_1_2_7_51_1
  doi: 10.1016/j.pneurobio.2008.04.001
– ident: e_1_2_7_14_1
  doi: 10.2174/1570159X15666170313123454
– ident: e_1_2_7_45_1
  doi: 10.1016/j.molcel.2011.03.005
– ident: e_1_2_7_9_1
  doi: 10.1126/science.1132813
– ident: e_1_2_7_79_1
  doi: 10.1111/j.1365-2990.2006.00795.x
– ident: e_1_2_7_8_1
  doi: 10.1111/jpi.12238
– ident: e_1_2_7_26_1
  doi: 10.1007/s10495-013-0917-4
– ident: e_1_2_7_60_1
  doi: 10.1038/21650
– ident: e_1_2_7_62_1
  doi: 10.1046/j.1471-4159.2003.01879.x
– ident: e_1_2_7_20_1
  doi: 10.1111/j.1600-079X.2006.00343.x
– ident: e_1_2_7_10_1
  doi: 10.1038/nrn2194
– ident: e_1_2_7_68_1
  doi: 10.1242/jcs.01558
– ident: e_1_2_7_16_1
  doi: 10.3390/ijms140714575
– ident: e_1_2_7_53_1
  doi: 10.1046/j.1432-1033.2003.03430.x
– ident: e_1_2_7_17_1
  doi: 10.1007/s12035-019-01660-3
– ident: e_1_2_7_33_1
  doi: 10.1001/archneurol.2007.3
– ident: e_1_2_7_81_1
  doi: 10.1046/j.1471-4159.1999.0722053.x
– ident: e_1_2_7_48_1
  doi: 10.1074/jbc.M610430200
– ident: e_1_2_7_43_1
  doi: 10.4049/jimmunol.0801892
– ident: e_1_2_7_55_1
  doi: 10.1016/j.bbagen.2019.129467
– ident: e_1_2_7_2_1
  doi: 10.1016/j.arr.2012.04.003
– ident: e_1_2_7_86_1
  doi: 10.1111/jpi.12470
– ident: e_1_2_7_24_1
  doi: 10.1007/s10495-013-0924-5
– volume: 118
  start-page: 1877
  issue: 5
  year: 2008
  ident: e_1_2_7_44_1
  article-title: Pin1 has opposite effects on wild‐type and P301L tau stability and tauopathy
  publication-title: J Clin Investig
– ident: e_1_2_7_42_1
  doi: 10.1016/S0896-6273(00)00147-1
– ident: e_1_2_7_58_1
  doi: 10.1017/S1462399411001906
– ident: e_1_2_7_65_1
  doi: 10.1016/0896-6273(89)90050-0
– ident: e_1_2_7_27_1
  doi: 10.1002/(SICI)1097-4547(19991201)58:5<674::AID-JNR8>3.0.CO;2-3
– volume: 4
  start-page: 125
  issue: 2
  year: 1996
  ident: e_1_2_7_67_1
  article-title: Microtubule‐associated proteins, phosphorylation gradients, and the establishment of neuronal polarity
  publication-title: Perspect Dev Neurobiol
– volume: 17
  start-page: 869
  issue: 5
  year: 2006
  ident: e_1_2_7_34_1
  article-title: Deletion of the kinase domain from death‐associated protein kinase enhances spatial memory in mice
  publication-title: Int J Mol Med
– ident: e_1_2_7_39_1
  doi: 10.1038/cdd.2011.2
– ident: e_1_2_7_56_1
  doi: 10.1021/jm901191q
– ident: e_1_2_7_30_1
  doi: 10.1074/jbc.M505804200
– volume: 25
  start-page: 2498
  issue: 12
  year: 2016
  ident: e_1_2_7_37_1
  article-title: Inhibition of death‐associated protein kinase 1 attenuates the phosphorylation and amyloidogenic processing of amyloid precursor protein
  publication-title: Hum Mol Genet
– ident: e_1_2_7_31_1
  doi: 10.2174/1574892814666181218170257
– ident: e_1_2_7_84_1
  doi: 10.1016/S0169-328X(02)00488-6
– ident: e_1_2_7_77_1
  doi: 10.1016/S0166-2236(98)01337-X
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Snippet Death‐associated protein kinase 1 (DAPK1) is upregulated in the brains of human Alzheimer's disease (AD) patients compared with normal subjects, and aberrant...
Death-associated protein kinase 1 (DAPK1) is upregulated in the brains of human Alzheimer's disease (AD) patients compared with normal subjects, and aberrant...
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StartPage e12665
SubjectTerms Alzheimer's disease
death‐associated protein kinase 1 (DAPK1)
melatonin
Pin1
tau
Title Melatonin directly binds and inhibits death‐associated protein kinase 1 function in Alzheimer’s disease
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjpi.12665
https://www.ncbi.nlm.nih.gov/pubmed/32358852
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https://pubmed.ncbi.nlm.nih.gov/PMC7890046
Volume 69
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