Deep residual inception encoder‐decoder network for amyloid PET harmonization

Introduction Multiple positron emission tomography (PET) tracers are available for amyloid imaging, posing a significant challenge to consensus interpretation and quantitative analysis. We accordingly developed and validated a deep learning model as a harmonization strategy. Method A Residual Incept...

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Published in:Alzheimer's & dementia Vol. 18; no. 12; pp. 2448 - 2457
Main Authors: Shah, Jay, Gao, Fei, Li, Baoxin, Ghisays, Valentina, Luo, Ji, Chen, Yinghua, Lee, Wendy, Zhou, Yuxiang, Benzinger, Tammie L.S., Reiman, Eric M., Chen, Kewei, Su, Yi, Wu, Teresa
Format: Journal Article
Language:English
Published: United States 01.12.2022
Subjects:
Alzheimer Disease - diagnostic imaging
Alzheimer's disease
Amyloid - metabolism
amyloid PET
Amyloidogenic Proteins
Aniline Compounds
Brain - diagnostic imaging
Brain - metabolism
Centiloid
Humans
Positron-Emission Tomography - methods
Radiopharmaceuticals
Alzheimer's disease
Centiloid
amyloid PET
ISSN:1552-5260, 1552-5279, 1552-5279
Online Access:Get full text
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Summary:Introduction Multiple positron emission tomography (PET) tracers are available for amyloid imaging, posing a significant challenge to consensus interpretation and quantitative analysis. We accordingly developed and validated a deep learning model as a harmonization strategy. Method A Residual Inception Encoder‐Decoder Neural Network was developed to harmonize images between amyloid PET image pairs made with Pittsburgh Compound‐B and florbetapir tracers. The model was trained using a dataset with 92 subjects with 10‐fold cross validation and its generalizability was further examined using an independent external dataset of 46 subjects. Results Significantly stronger between‐tracer correlations (P < .001) were observed after harmonization for both global amyloid burden indices and voxel‐wise measurements in the training cohort and the external testing cohort. Discussion We proposed and validated a novel encoder‐decoder based deep model to harmonize amyloid PET imaging data from different tracers. Further investigation is ongoing to improve the model and apply to additional tracers.
Bibliography:Yi Su and Teresa Wu contributed equally to this work.
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ISSN:1552-5260
1552-5279
1552-5279
DOI:10.1002/alz.12564