Potential for pharmacokinetic interactions between Schisandra sphenanthera and bosutinib, but not imatinib: in vitro metabolism study combined with a physiologically‐based pharmacokinetic modelling approach

Aims This study aimed to investigate the potential interaction between Schisandra sphenanthera, imatinib and bosutinib combining in vitro and in silico methods. Methods In vitro metabolism of imatinib and bosutinib using recombinant enzymes and human liver microsomes were investigated in the presenc...

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Bibliographic Details

Published in:	British journal of clinical pharmacology Vol. 86; no. 10; pp. 2080 - 2094
Main Authors:	Adiwidjaja, Jeffry, Boddy, Alan V., McLachlan, Andrew J.
Format:	Journal Article
Language:	English
Published:	England John Wiley and Sons Inc 01.10.2020
Subjects:	drug metabolism herb–drug interactions modelling and simulation Original physiologically‐based pharmacokinetic (PBPK) physiologically-based pharmacokinetic (PBPK) modelling and simulation herb-drug interactions drug metabolism
ISSN:	0306-5251, 1365-2125, 1365-2125
Online Access:	Get full text
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