Potential for pharmacokinetic interactions between Schisandra sphenanthera and bosutinib, but not imatinib: in vitro metabolism study combined with a physiologically‐based pharmacokinetic modelling approach

Aims This study aimed to investigate the potential interaction between Schisandra sphenanthera, imatinib and bosutinib combining in vitro and in silico methods. Methods In vitro metabolism of imatinib and bosutinib using recombinant enzymes and human liver microsomes were investigated in the presenc...

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Vydáno v:	British journal of clinical pharmacology Ročník 86; číslo 10; s. 2080 - 2094
Hlavní autoři:	Adiwidjaja, Jeffry, Boddy, Alan V., McLachlan, Andrew J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England John Wiley and Sons Inc 01.10.2020
Témata:	drug metabolism herb–drug interactions modelling and simulation Original physiologically‐based pharmacokinetic (PBPK) physiologically-based pharmacokinetic (PBPK) modelling and simulation herb-drug interactions drug metabolism
ISSN:	0306-5251, 1365-2125, 1365-2125
On-line přístup:	Získat plný text
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