Establishment of induced pluripotent stem cell lines derived from Parkinson’s disease Mexican patients: A sporadic (UNAMi002-A) and a familial (UNAMi003-A) case carrying a mutation in PINK1

Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta, which results in a prominent reduction of striatal dopamine levels leading to motor alterations. The mechanisms underlying neurodegeneration in PD remain unknown. Here, we...

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Veröffentlicht in:	Stem cell research Jg. 76; S. 103337
Hauptverfasser:	Flores-Ponce, Xóchitl, López-Ornelas, Adolfo, Escobedo-Avila, Itzel, Rodríguez-Violante, Mayela, Dávila-Ortiz de Montellano, David, Cervantes-Arriaga, Amín, Monroy-Jaramillo, Nancy, Campos-Romo, Aurelio, Velasco, Iván
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier B.V 01.04.2024 Elsevier
Schlagworte:	Dopamine - metabolism Dopaminergic Neurons - metabolism Humans Induced Pluripotent Stem Cells - metabolism Mutation - genetics Parkinson Disease - genetics Parkinson Disease - metabolism Protein Kinases - genetics
ISSN:	1873-5061, 1876-7753, 1876-7753
Online-Zugang:	Volltext
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