Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open‐label, phase I study in healthy subjects

Valemetostat tosylate (valemetostat) is an oral, potent, dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1 under investigation for the treatment of cancer, including non‐Hodgkin's lymphomas and solid tumors. Itraconazole and fluconazole are antifungal medications often used as typica...

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Bibliographic Details
Published in:	Clinical and translational science Vol. 16; no. 11; pp. 2153 - 2162
Main Authors:	Tachibana, Masaya, Matsuki, Shunji, Maekawa, Yutaro, Kuroda, Kana, Shimizu, Takako, Tsutsumi, Junko, Ishizuka, Hitoshi
Format:	Journal Article
Language:	English
Published:	United States John Wiley & Sons, Inc 01.11.2023 Wiley
Subjects:	Antifungal agents Area Under Curve Beverages Cross-Over Studies Cytochrome Cytochrome P-450 CYP3A - metabolism Cytochrome P-450 CYP3A Inhibitors Cytochrome P450 Drug dosages Drug interaction Drug Interactions Enzyme Inhibitors Fluconazole Fluconazole - adverse effects Glycoproteins Healthy Volunteers Humans Itraconazole Itraconazole - adverse effects Leukemia Lymphoma Male Neoplasms Non-Hodgkin's lymphoma P-Glycoprotein Pharmaceuticals Pharmacokinetics Plasma Solid tumors Japan
ISSN:	1752-8054, 1752-8062, 1752-8062
Online Access:	Get full text
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