Synthetic and biosynthetic routes to nitrogen-nitrogen bonds

The nitrogen-nitrogen bond is a core feature of diverse functional groups like hydrazines, nitrosamines, diazos, and pyrazoles. Such functional groups are found in >300 known natural products. Such N-N bond-containing functional groups are also found in significant percentage of clinical drugs. T...

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Vydáno v:Chemical Society reviews Ročník 51; číslo 8; s. 2991
Hlavní autoři: He, Hai-Yan, Niikura, Haruka, Du, Yi-Ling, Ryan, Katherine S
Médium: Journal Article
Jazyk:angličtina
Vydáno: England 19.04.2022
Témata:
Biological Products - chemistry
Biosynthetic Pathways
Hydrazines - chemistry
Hydrazines - metabolism
Nitrogen - chemistry
ISSN:1460-4744, 1460-4744
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Shrnutí:The nitrogen-nitrogen bond is a core feature of diverse functional groups like hydrazines, nitrosamines, diazos, and pyrazoles. Such functional groups are found in >300 known natural products. Such N-N bond-containing functional groups are also found in significant percentage of clinical drugs. Therefore, there is wide interest in synthetic and enzymatic methods to form nitrogen-nitrogen bonds. In this review, we summarize synthetic and biosynthetic approaches to diverse nitrogen-nitrogen-bond-containing functional groups, with a focus on biosynthetic pathways and enzymes.
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ISSN:1460-4744
1460-4744
DOI:10.1039/c7cs00458c