Synthetic and biosynthetic routes to nitrogen-nitrogen bonds
The nitrogen-nitrogen bond is a core feature of diverse functional groups like hydrazines, nitrosamines, diazos, and pyrazoles. Such functional groups are found in >300 known natural products. Such N-N bond-containing functional groups are also found in significant percentage of clinical drugs. T...
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| Vydáno v: | Chemical Society reviews Ročník 51; číslo 8; s. 2991 |
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| Hlavní autoři: | , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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England
19.04.2022
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| ISSN: | 1460-4744, 1460-4744 |
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| Abstract | The nitrogen-nitrogen bond is a core feature of diverse functional groups like hydrazines, nitrosamines, diazos, and pyrazoles. Such functional groups are found in >300 known natural products. Such N-N bond-containing functional groups are also found in significant percentage of clinical drugs. Therefore, there is wide interest in synthetic and enzymatic methods to form nitrogen-nitrogen bonds. In this review, we summarize synthetic and biosynthetic approaches to diverse nitrogen-nitrogen-bond-containing functional groups, with a focus on biosynthetic pathways and enzymes. |
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| AbstractList | The nitrogen-nitrogen bond is a core feature of diverse functional groups like hydrazines, nitrosamines, diazos, and pyrazoles. Such functional groups are found in >300 known natural products. Such N-N bond-containing functional groups are also found in significant percentage of clinical drugs. Therefore, there is wide interest in synthetic and enzymatic methods to form nitrogen-nitrogen bonds. In this review, we summarize synthetic and biosynthetic approaches to diverse nitrogen-nitrogen-bond-containing functional groups, with a focus on biosynthetic pathways and enzymes. The nitrogen-nitrogen bond is a core feature of diverse functional groups like hydrazines, nitrosamines, diazos, and pyrazoles. Such functional groups are found in >300 known natural products. Such N-N bond-containing functional groups are also found in significant percentage of clinical drugs. Therefore, there is wide interest in synthetic and enzymatic methods to form nitrogen-nitrogen bonds. In this review, we summarize synthetic and biosynthetic approaches to diverse nitrogen-nitrogen-bond-containing functional groups, with a focus on biosynthetic pathways and enzymes.The nitrogen-nitrogen bond is a core feature of diverse functional groups like hydrazines, nitrosamines, diazos, and pyrazoles. Such functional groups are found in >300 known natural products. Such N-N bond-containing functional groups are also found in significant percentage of clinical drugs. Therefore, there is wide interest in synthetic and enzymatic methods to form nitrogen-nitrogen bonds. In this review, we summarize synthetic and biosynthetic approaches to diverse nitrogen-nitrogen-bond-containing functional groups, with a focus on biosynthetic pathways and enzymes. |
| Author | He, Hai-Yan Du, Yi-Ling Niikura, Haruka Ryan, Katherine S |
| Author_xml | – sequence: 1 givenname: Hai-Yan orcidid: 0000-0002-3540-1707 surname: He fullname: He, Hai-Yan email: ksryan@chem.ubc.ca, hehaiyan@imb.cams.cn organization: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. hehaiyan@imb.cams.cn – sequence: 2 givenname: Haruka orcidid: 0000-0001-6732-6978 surname: Niikura fullname: Niikura, Haruka email: ksryan@chem.ubc.ca organization: Department of Chemistry, University of British Columbia, Vancouver, Canada. ksryan@chem.ubc.ca – sequence: 3 givenname: Yi-Ling orcidid: 0000-0001-7072-4803 surname: Du fullname: Du, Yi-Ling organization: Institute of Pharmaceutical Biotechnology, Zhejiang University School of Medicine, Hangzhou, China – sequence: 4 givenname: Katherine S orcidid: 0000-0003-1643-1940 surname: Ryan fullname: Ryan, Katherine S email: ksryan@chem.ubc.ca organization: Department of Chemistry, University of British Columbia, Vancouver, Canada. ksryan@chem.ubc.ca |
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| SubjectTerms | Biological Products - chemistry Biosynthetic Pathways Hydrazines - chemistry Hydrazines - metabolism Nitrogen - chemistry |
| Title | Synthetic and biosynthetic routes to nitrogen-nitrogen bonds |
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