Questioning risk compensation: pre-exposure prophylaxis (PrEP) and sexually transmitted infections among men who have sex with men, capital region of Denmark, 2019 to 2022
BackgroundPre-exposure prophylaxis (PrEP) effectively prevents HIV, but its association with sexually transmitted infections (STIs) has raised concerns about risk compensation, potentially impacting the expansion of PrEP programmes.AimWe examined the relationship between PrEP and the incidence of ch...
Gespeichert in:
| Veröffentlicht in: | Euro surveillance : bulletin européen sur les maladies transmissibles Jg. 29; H. 13; S. 1 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Sweden
Centre Europeen pour la Surveillance Epidemiologique du SIDA (European Centre for the Epidemiological Monitoring of AIDS)
28.03.2024
|
| Schlagworte: | |
| ISSN: | 1560-7917, 1025-496X, 1560-7917 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | BackgroundPre-exposure prophylaxis (PrEP) effectively prevents HIV, but its association with sexually transmitted infections (STIs) has raised concerns about risk compensation, potentially impacting the expansion of PrEP programmes.AimWe examined the relationship between PrEP and the incidence of chlamydia, gonorrhoea and syphilis.MethodsIn this prospective cohort study, we compared STI rates before and after PrEP initiation among users in the capital region of Denmark (2019-2022), calculating incidence rate ratios adjusted for age and testing frequency (aIRR). To pinpoint when increases began, we plotted weekly STI rates, adjusting the timeline to correspond with PrEP initiation.ResultsThe study included 1,326 PrEP users with a median age of 35 years. The STI incidence rate per 100,000 person-years rose from 35.3 before to 81.2 after PrEP start, with an aIRR of 1.35 (95% CI: 1.18-1.56). Notably, this increase preceded PrEP initiation by 10-20 weeks. Specific aIRR for chlamydia, gonorrhoea and syphilis were 1.23 (95% CI: 1.03-1.48), 1.24 (95% CI: 1.04-1.47) and 1.15 (95% CI: 0.76-1.72), respectively. In subanalyses for anatomical sites aIRR was 1.26 (95% CI: 1.01-1.56) for rectal chlamydia and 0.66 (95% CI: 0.45-0.96) for genital gonorrhoea.ConclusionWe found a 35% increase in STI incidence associated with PrEP use. It started before PrEP initiation, challenging the assumption that PrEP leads to risk compensation. Instead, the data suggest that individuals seek PrEP during periods of heightened sexual risk-taking. Consequently, PrEP programmes should include sexual health consultations, STI testing, treatment and prevention strategies to prevent HIV and improve sexual health. |
|---|---|
| AbstractList | BackgroundPre-exposure prophylaxis (PrEP) effectively prevents HIV, but its association with sexually transmitted infections (STIs) has raised concerns about risk compensation, potentially impacting the expansion of PrEP programmes.AimWe examined the relationship between PrEP and the incidence of chlamydia, gonorrhoea and syphilis.MethodsIn this prospective cohort study, we compared STI rates before and after PrEP initiation among users in the capital region of Denmark (2019-2022), calculating incidence rate ratios adjusted for age and testing frequency (aIRR). To pinpoint when increases began, we plotted weekly STI rates, adjusting the timeline to correspond with PrEP initiation.ResultsThe study included 1,326 PrEP users with a median age of 35 years. The STI incidence rate per 100,000 person-years rose from 35.3 before to 81.2 after PrEP start, with an aIRR of 1.35 (95% CI: 1.18-1.56). Notably, this increase preceded PrEP initiation by 10-20 weeks. Specific aIRR for chlamydia, gonorrhoea and syphilis were 1.23 (95% CI: 1.03-1.48), 1.24 (95% CI: 1.04-1.47) and 1.15 (95% CI: 0.76-1.72), respectively. In subanalyses for anatomical sites aIRR was 1.26 (95% CI: 1.01-1.56) for rectal chlamydia and 0.66 (95% CI: 0.45-0.96) for genital gonorrhoea.ConclusionWe found a 35% increase in STI incidence associated with PrEP use. It started before PrEP initiation, challenging the assumption that PrEP leads to risk compensation. Instead, the data suggest that individuals seek PrEP during periods of heightened sexual risk-taking. Consequently, PrEP programmes should include sexual health consultations, STI testing, treatment and prevention strategies to prevent HIV and improve sexual health. BackgroundPre-exposure prophylaxis (PrEP) effectively prevents HIV, but its association with sexually transmitted infections (STIs) has raised concerns about risk compensation, potentially impacting the expansion of PrEP programmes.AimWe examined the relationship between PrEP and the incidence of chlamydia, gonorrhoea and syphilis.MethodsIn this prospective cohort study, we compared STI rates before and after PrEP initiation among users in the capital region of Denmark (2019-2022), calculating incidence rate ratios adjusted for age and testing frequency (aIRR). To pinpoint when increases began, we plotted weekly STI rates, adjusting the timeline to correspond with PrEP initiation.ResultsThe study included 1,326 PrEP users with a median age of 35 years. The STI incidence rate per 100,000 person-years rose from 35.3 before to 81.2 after PrEP start, with an aIRR of 1.35 (95% CI: 1.18-1.56). Notably, this increase preceded PrEP initiation by 10-20 weeks. Specific aIRR for chlamydia, gonorrhoea and syphilis were 1.23 (95% CI: 1.03-1.48), 1.24 (95% CI: 1.04-1.47) and 1.15 (95% CI: 0.76-1.72), respectively. In subanalyses for anatomical sites aIRR was 1.26 (95% CI: 1.01-1.56) for rectal chlamydia and 0.66 (95% CI: 0.45-0.96) for genital gonorrhoea.ConclusionWe found a 35% increase in STI incidence associated with PrEP use. It started before PrEP initiation, challenging the assumption that PrEP leads to risk compensation. Instead, the data suggest that individuals seek PrEP during periods of heightened sexual risk-taking. Consequently, PrEP programmes should include sexual health consultations, STI testing, treatment and prevention strategies to prevent HIV and improve sexual health.BackgroundPre-exposure prophylaxis (PrEP) effectively prevents HIV, but its association with sexually transmitted infections (STIs) has raised concerns about risk compensation, potentially impacting the expansion of PrEP programmes.AimWe examined the relationship between PrEP and the incidence of chlamydia, gonorrhoea and syphilis.MethodsIn this prospective cohort study, we compared STI rates before and after PrEP initiation among users in the capital region of Denmark (2019-2022), calculating incidence rate ratios adjusted for age and testing frequency (aIRR). To pinpoint when increases began, we plotted weekly STI rates, adjusting the timeline to correspond with PrEP initiation.ResultsThe study included 1,326 PrEP users with a median age of 35 years. The STI incidence rate per 100,000 person-years rose from 35.3 before to 81.2 after PrEP start, with an aIRR of 1.35 (95% CI: 1.18-1.56). Notably, this increase preceded PrEP initiation by 10-20 weeks. Specific aIRR for chlamydia, gonorrhoea and syphilis were 1.23 (95% CI: 1.03-1.48), 1.24 (95% CI: 1.04-1.47) and 1.15 (95% CI: 0.76-1.72), respectively. In subanalyses for anatomical sites aIRR was 1.26 (95% CI: 1.01-1.56) for rectal chlamydia and 0.66 (95% CI: 0.45-0.96) for genital gonorrhoea.ConclusionWe found a 35% increase in STI incidence associated with PrEP use. It started before PrEP initiation, challenging the assumption that PrEP leads to risk compensation. Instead, the data suggest that individuals seek PrEP during periods of heightened sexual risk-taking. Consequently, PrEP programmes should include sexual health consultations, STI testing, treatment and prevention strategies to prevent HIV and improve sexual health. Background Pre-exposure prophylaxis (PrEP) effectively prevents HIV, but its association with sexually transmitted infections (STIs) has raised concerns about risk compensation, potentially impacting the expansion of PrEP programmes. Aim We examined the relationship between PrEP and the incidence of chlamydia, gonorrhoea and syphilis. Methods In this prospective cohort study, we compared STI rates before and after PrEP initiation among users in the capital region of Denmark (2019–2022), calculating incidence rate ratios adjusted for age and testing frequency (aIRR). To pinpoint when increases began, we plotted weekly STI rates, adjusting the timeline to correspond with PrEP initiation. Results The study included 1,326 PrEP users with a median age of 35 years. The STI incidence rate per 100,000 person-years rose from 35.3 before to 81.2 after PrEP start, with an aIRR of 1.35 (95% CI: 1.18–1.56). Notably, this increase preceded PrEP initiation by 10–20 weeks. Specific aIRR for chlamydia, gonorrhoea and syphilis were 1.23 (95% CI: 1.03–1.48), 1.24 (95% CI: 1.04–1.47) and 1.15 (95% CI: 0.76–1.72), respectively. In subanalyses for anatomical sites aIRR was 1.26 (95% CI: 1.01–1.56) for rectal chlamydia and 0.66 (95% CI: 0.45–0.96) for genital gonorrhoea. Conclusion We found a 35% increase in STI incidence associated with PrEP use. It started before PrEP initiation, challenging the assumption that PrEP leads to risk compensation. Instead, the data suggest that individuals seek PrEP during periods of heightened sexual risk-taking. Consequently, PrEP programmes should include sexual health consultations, STI testing, treatment and prevention strategies to prevent HIV and improve sexual health. |
| Author | Ahlström, Magnus Glindvad Nielsen, Lars Nørregaard Kronborg, Gitte Gerstoft, Jan Engsig, Frederik N Christensen, Hanne Lebech, Anne-Mette Harritshøj, Lene Holm Pedersen, Susanne Kriegel Hertz, Frederik Boetius Lunding, Suzanne von Schreeb, Sebastian Jørgsensen, Kristina Melbardis |
| Author_xml | – sequence: 1 givenname: Sebastian orcidid: 0000-0002-1442-2621 surname: von Schreeb fullname: von Schreeb, Sebastian organization: Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark, Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Copenhagen, Denmark – sequence: 2 givenname: Susanne Kriegel surname: Pedersen fullname: Pedersen, Susanne Kriegel organization: Department of Infectious Diseases, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark – sequence: 3 givenname: Hanne surname: Christensen fullname: Christensen, Hanne organization: Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Copenhagen, Denmark – sequence: 4 givenname: Kristina Melbardis surname: Jørgsensen fullname: Jørgsensen, Kristina Melbardis organization: Department of Clinical Microbiology, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark – sequence: 5 givenname: Lene Holm surname: Harritshøj fullname: Harritshøj, Lene Holm organization: Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, Department of Clinical Immunology, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark – sequence: 6 givenname: Frederik Boetius surname: Hertz fullname: Hertz, Frederik Boetius organization: Department of Clinical Microbiology, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark – sequence: 7 givenname: Magnus Glindvad surname: Ahlström fullname: Ahlström, Magnus Glindvad organization: Department of Clinical Microbiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark – sequence: 8 givenname: Anne-Mette surname: Lebech fullname: Lebech, Anne-Mette organization: Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, Department of Infectious Diseases, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark – sequence: 9 givenname: Suzanne surname: Lunding fullname: Lunding, Suzanne organization: Department of Internal Medicine, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, Denmark – sequence: 10 givenname: Lars Nørregaard surname: Nielsen fullname: Nielsen, Lars Nørregaard organization: Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital – North Zealand Hospital, Copenhagen, Denmark – sequence: 11 givenname: Jan surname: Gerstoft fullname: Gerstoft, Jan organization: Department of Infectious Diseases, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark – sequence: 12 givenname: Gitte surname: Kronborg fullname: Kronborg, Gitte organization: Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Copenhagen, Denmark – sequence: 13 givenname: Frederik N surname: Engsig fullname: Engsig, Frederik N organization: Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Copenhagen, Denmark |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38551099$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkctu1TAQhi1URC_wCsgSC1qpJ_iWi7tBqA0XqRJFhbXlJJMet4kd7ISe80y8JLZ6qFBXrMYeffNr5v8P0Z51FhB6S0nGKlK-o3lBVqWkZVZfZ4wwkTGZUZ4xTojI6TN08Ejs_fPeR4ch3EaEE8leoH1e5TklUh6g398WCLNx1tgb7E24w60bJ7BBp-YZnjysYDO5sHiIHzett4PemICPr3x9dYK17XCAzaKHYYtnr20YzTxDh43toU0aAevRRfERLL5fO7zWvyCN4Hszr1P3FLd6MrMesIebOIBdjy_AjtrfnWJGqMSzi5Wxl-h5r4cAr3b1CP34WH8__7y6_Prpy_mHy1UrqJhXPOdABQjgeVHoomh0U_BGV6LqG95LWVY57SQUHeURJAWhXNJeMy50o4uu4Ufo-EE33vsz2aNGE1oYBm3BLUHxuEteEilIRN88QW_d4m3cLlGilKWoeKRe76ilGaFTkzfxuq36G0ME3j8ArXcheOgfEUpUCl6lKFWKUtXXKgWvmFSUq13wUaF-otBGS5P_MRQz_LfOH0aVtro |
| CitedBy_id | crossref_primary_10_1093_eurpub_ckaf034 crossref_primary_10_3138_jammi_2024_0027 crossref_primary_10_1093_ofid_ofaf491 crossref_primary_10_4102_jphia_v16i1_1306 crossref_primary_10_1038_s41591_025_03535_8 crossref_primary_10_1080_15381501_2025_2540865 crossref_primary_10_2196_65713 |
| Cites_doi | 10.1001/jama.2019.2947 10.1001/jamanetworkopen.2020.30806 10.1016/S0140-6736(15)00056-2 10.1016/S2352-3018(19)30136-5 10.1136/ip.6.2.82 10.2105/AJPH.2017.303930 10.1097/QAD.0000000000001874 10.1097/QAD.0000000000001718 10.1097/00002030-200211220-00022 10.1097/QAI.0000000000001885 10.1007/s11904-019-00446-5 10.1016/S2352-3018(19)30333-9 10.1126/scitranslmed.3004006 10.1093/cid/ciy182 10.1177/15579883211018917 10.1371/journal.pone.0245925 10.1097/OLQ.0000000000001189 |
| ContentType | Journal Article |
| Copyright | Copyright Centre Europeen pour la Surveillance Epidemiologique du SIDA (European Centre for the Epidemiological Monitoring of AIDS) Mar 28, 2024 |
| Copyright_xml | – notice: Copyright Centre Europeen pour la Surveillance Epidemiologique du SIDA (European Centre for the Epidemiological Monitoring of AIDS) Mar 28, 2024 |
| DBID | AAYXX CITATION NPM 7X8 |
| DOI | 10.2807/1560-7917.ES.2024.29.13.2300451 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Public Health |
| EISSN | 1560-7917 |
| ExternalDocumentID | 38551099 10_2807_1560_7917_ES_2024_29_13_2300451 |
| Genre | Journal Article |
| GeographicLocations | Denmark |
| GeographicLocations_xml | – name: Denmark |
| GroupedDBID | --- 2WC 53G 5GY 5VS 9K5 AAYXX ABOCM ADBBV AENEX ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK E3Z EBD EBS EJD EMOBN F5P FRP GROUPED_DOAJ GX1 HYE KQ8 M48 OK1 OVT P6G PQQKQ RNS RPM SV3 TR2 XSB ADRAZ FZ- IPNFZ NPM RIG 7X8 |
| ID | FETCH-LOGICAL-c414t-353e14e4e3566a66bab63ba848fb3f997851d9e6d133e10601391fa234aba6db3 |
| ISICitedReferencesCount | 11 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001235580600003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1560-7917 1025-496X |
| IngestDate | Wed Oct 01 13:20:39 EDT 2025 Mon Jun 30 12:44:25 EDT 2025 Mon Jul 21 05:53:54 EDT 2025 Tue Nov 18 22:37:47 EST 2025 Sat Nov 29 03:13:54 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 13 |
| Keywords | Chlamydia HIV risk compensation Syphilis Pre-exposure Prophylaxis Gonorrhea PrEP, Gonorrhoea |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c414t-353e14e4e3566a66bab63ba848fb3f997851d9e6d133e10601391fa234aba6db3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-1442-2621 |
| OpenAccessLink | https://www.eurosurveillance.org/deliver/fulltext/eurosurveillance/29/13/eurosurv-29-13_4.pdf?itemId=%2Fcontent%2F10.2807%2F1560-7917.ES.2024.29.13.2300451&mimeType=pdf&containerItemId=content/eurosurveillance |
| PMID | 38551099 |
| PQID | 3024797483 |
| PQPubID | 105456 |
| ParticipantIDs | proquest_miscellaneous_3022570940 proquest_journals_3024797483 pubmed_primary_38551099 crossref_primary_10_2807_1560_7917_ES_2024_29_13_2300451 crossref_citationtrail_10_2807_1560_7917_ES_2024_29_13_2300451 |
| PublicationCentury | 2000 |
| PublicationDate | 2024-03-28 |
| PublicationDateYYYYMMDD | 2024-03-28 |
| PublicationDate_xml | – month: 03 year: 2024 text: 2024-03-28 day: 28 |
| PublicationDecade | 2020 |
| PublicationPlace | Sweden |
| PublicationPlace_xml | – name: Sweden – name: Saint-Maurice |
| PublicationTitle | Euro surveillance : bulletin européen sur les maladies transmissibles |
| PublicationTitleAlternate | Euro Surveill |
| PublicationYear | 2024 |
| Publisher | Centre Europeen pour la Surveillance Epidemiologique du SIDA (European Centre for the Epidemiological Monitoring of AIDS) |
| Publisher_xml | – name: Centre Europeen pour la Surveillance Epidemiologique du SIDA (European Centre for the Epidemiological Monitoring of AIDS) |
| References | r3 r4 Page-Shafer (r20) 2002; 16 Nguyen (r21) 2018; 32 Traeger (r6) 2022; 19 Konnoth (r13) 2019; 105 McManus (r29) 2020; 3 Anderson (r2) 2012; 4 Hoornenborg (r17) 2018; 32 Hedlund (r10) 2000; 6 Ayerdi Aguirrebengoa (r16) 2021; 16 Hoornenborg (r18) 2019; 6 r19 McCormack (r1) 2016; 387 Quaife (r7) 2020; 7 Blumenthal (r9) 2014; 16 Traeger (r14) 2018; 67 Rojas Castro (r12) 2019; 22 Ramchandani (r5) 2019; 16 Nguyen (r27) 2018; 32 Earnest (r30) 2020; 47 Azarnoosh (r26) 2021; 15 r23 McCormack (r28) 2016; 387 Milam (r8) 2019; 80 r22 r25 r24 Holt (r11) 2017; 107 Traeger (r15) 2019; 321 |
| References_xml | – volume: 16 start-page: 909 issue: 11 year: 2014 ident: r9 article-title: Will risk compensation accompany pre-exposure prophylaxis for HIV? publication-title: Virtual Mentor – volume: 321 start-page: 1380 issue: 14 year: 2019 ident: r15 article-title: Association of HIV preexposure prophylaxis with incidence of sexually transmitted infections among individuals at high risk of HIV infection. publication-title: JAMA doi: 10.1001/jama.2019.2947 – volume: 3 issue: 12 year: 2020 ident: r29 article-title: Comparison of trends in rates of sexually transmitted infections before vs after initiation of HIV preexposure prophylaxis among men who have sex with men. publication-title: JAMA Netw Open doi: 10.1001/jamanetworkopen.2020.30806 – volume: 22 issue: Suppl year: 2019 ident: r12 article-title: Give PrEP a chance: moving on from the "risk compensation" concept. publication-title: J Int AIDS Soc – ident: r19 – volume: 387 start-page: 53 issue: 10013 year: 2016 ident: r28 article-title: Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial. publication-title: Lancet doi: 10.1016/S0140-6736(15)00056-2 – ident: r25 – ident: r23 – volume: 6 start-page: e447 issue: 7 year: 2019 ident: r18 article-title: Sexual behaviour and incidence of HIV and sexually transmitted infections among men who have sex with men using daily and event-driven pre-exposure prophylaxis in AMPrEP: 2 year results from a demonstration study. publication-title: Lancet HIV doi: 10.1016/S2352-3018(19)30136-5 – volume: 6 start-page: 82 issue: 2 year: 2000 ident: r10 article-title: Risky business: safety regulations, risks compensation, and individual behavior. publication-title: Inj Prev doi: 10.1136/ip.6.2.82 – volume: 107 start-page: 1568 issue: 10 year: 2017 ident: r11 article-title: Individual versus community-level risk compensation following preexposure prophylaxis of HIV. publication-title: Am J Public Health doi: 10.2105/AJPH.2017.303930 – volume: 32 start-page: 1527 issue: 11 year: 2018 ident: r17 article-title: Change in sexual risk behaviour after 6 months of pre-exposure prophylaxis use: results from the Amsterdam pre-exposure prophylaxis demonstration project. publication-title: AIDS doi: 10.1097/QAD.0000000000001874 – volume: 32 start-page: 523 issue: 4 year: 2018 ident: r27 article-title: Incidence of sexually transmitted infections before and after preexposure prophylaxis for HIV. publication-title: AIDS doi: 10.1097/QAD.0000000000001718 – ident: r4 – volume: 19 start-page: 265 issue: 4 year: 2022 ident: r6 article-title: Why risk matters for STI control: who are those at greatest risk and how are they identified? publication-title: Sex Health – volume: 16 start-page: 2350 issue: 17 year: 2002 ident: r20 article-title: Risk of HIV infection attributable to oral sex among men who have sex with men and in the population of men who have sex with men. publication-title: AIDS doi: 10.1097/00002030-200211220-00022 – volume: 80 start-page: e9 issue: 1 year: 2019 ident: r8 article-title: Sexual risk compensation in a pre-exposure prophylaxis demonstration study among individuals at risk for HIV. publication-title: J Acquir Immune Defic Syndr doi: 10.1097/QAI.0000000000001885 – volume: 16 start-page: 244 issue: 3 year: 2019 ident: r5 article-title: Confronting rising STIs in the era of PrEP and treatment as prevention. publication-title: Curr HIV/AIDS Rep doi: 10.1007/s11904-019-00446-5 – volume: 7 start-page: e222 issue: 4 year: 2020 ident: r7 article-title: Risk compensation and STI incidence in PrEP programmes. publication-title: Lancet HIV doi: 10.1016/S2352-3018(19)30333-9 – volume: 105 start-page: 171 year: 2019 ident: r13 article-title: Drugs’ other side-effects. publication-title: Iowa Law Rev – ident: r22 – volume: 387 start-page: 53 issue: 10013 year: 2016 ident: r1 article-title: Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial. publication-title: Lancet doi: 10.1016/S0140-6736(15)00056-2 – ident: r24 – volume: 4 issue: 151 year: 2012 ident: r2 article-title: Emtricitabine-tenofovir concentrations and pre-exposure prophylaxis efficacy in men who have sex with men. publication-title: Sci Transl Med doi: 10.1126/scitranslmed.3004006 – volume: 67 start-page: 676 issue: 5 year: 2018 ident: r14 article-title: Effects of pre-exposure prophylaxis for the prevention of human immunodeficiency virus infection on sexual risk behavior in men who have sex with men: a systematic review and meta-analysis. publication-title: Clin Infect Dis doi: 10.1093/cid/ciy182 – volume: 15 issue: 3 year: 2021 ident: r26 article-title: Incidence of sexually transmitted infections after initiating HIV pre-exposure prophylaxis among MSM in southern Denmark. publication-title: Am J Mens Health doi: 10.1177/15579883211018917 – volume: 16 issue: 2 year: 2021 ident: r16 article-title: Low use of condom and high STI incidence among men who have sex with men in PrEP programs. publication-title: PLoS One doi: 10.1371/journal.pone.0245925 – ident: r3 – volume: 47 start-page: 484 issue: 7 year: 2020 ident: r30 article-title: Population-level benefits of extragenital gonorrhea screening among men who have sex with men: an exploratory modeling analysis. publication-title: Sex Transm Dis doi: 10.1097/OLQ.0000000000001189 – volume: 32 start-page: 523 issue: 4 year: 2018 ident: r21 article-title: Incidence of sexually transmitted infections before and after preexposure prophylaxis for HIV. publication-title: AIDS doi: 10.1097/QAD.0000000000001718 |
| SSID | ssj0043092 |
| Score | 2.4474738 |
| Snippet | BackgroundPre-exposure prophylaxis (PrEP) effectively prevents HIV, but its association with sexually transmitted infections (STIs) has raised concerns about... Background Pre-exposure prophylaxis (PrEP) effectively prevents HIV, but its association with sexually transmitted infections (STIs) has raised concerns about... |
| SourceID | proquest pubmed crossref |
| SourceType | Aggregation Database Index Database Enrichment Source |
| StartPage | 1 |
| SubjectTerms | Antiretroviral drugs Disease prevention Gays & lesbians Health risks Mens health Sexual health Sexually transmitted diseases STD |
| Title | Questioning risk compensation: pre-exposure prophylaxis (PrEP) and sexually transmitted infections among men who have sex with men, capital region of Denmark, 2019 to 2022 |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/38551099 https://www.proquest.com/docview/3024797483 https://www.proquest.com/docview/3022570940 |
| Volume | 29 |
| WOSCitedRecordID | wos001235580600003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Open Access Full Text customDbUrl: eissn: 1560-7917 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0043092 issn: 1560-7917 databaseCode: DOA dateStart: 19960101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1ti9NAEF6up4gg4rvV81hBUMm1Jtk0yfpB8KVyCB6FntBvYZNsvEKalCZX6m_yTzqzu0lTUayCX0pINpOls8_uzOyzM4Q883w3S0YjdyBEGoKDwiVcBXLgOmkQxhk4XYlQxSaCs7NwNuOTg96n5izMOg-KItxs-PK_qhrugbLx6OxfqLsVCjfgGpQOv6B2-N1L8SqEaaKsijiOrHFwVlsaBxI_5GZZYmwQ-VnwR-diM1fh18lqPMFAgQqnq2zM-TcsI1FUi3mNxmlD3ioqU6dogQfBL0rrAssYwSs6srvQs1kiVFESC8s_aMP0gywWhp4NRgFH09e19Znh7gaBBZ1bS6yIhBMP9jo2ecItzCay1Pv78GloZ-WyshYiR_Ja1XQWoZ5v-ZFrnBYTGLdS7T9NJazedQcZE8ypYYJRiqgEtjfMf9Iwftt8xMj3161OsU3LP8L-vAtXX6v2uZ49C2F9lnmMMNwJsLgeMszcnTXBtzGrZ9BdNEyYxoCD_WoxwjxDGBdpXh-Op0OUP3T50GHIwMfcPtt1uOEe_LQ8t6RJcNdQZIQCIxQYjacRCoxcHjksMgJ75IobjDhvwgvaKvGYrQqEt725Rp6bPr76Qw93LbbfuGHKHDu_RW4aP4q-1eP_NjmQxR1yQwehqT5bd5d872CBIhZoFwuvaRcJtIME-gJx8JICCmiDAtpBAd2igCoUUBjvFFBAEQX4CkUU4N0TajBANQZomVGDgROKCKB1SREB98iXj-Pz96cDU51kkHiOVw_YiEnHk55k4BEJ349F7LNYhF6YxSzjPABfJuXSTx0GDTHtEeNOJlzmiVj4aczuk8OiLORDQjN_xEGWk2DwAjQiUm67qR27sUicWPp98qbRQJSY1P1YQSaP9hwTfRK2ApY6i83-rx41Ko_MLFdFDJoFPPBC1idP28eAbdxtFIUsL1UbrJDJPbtPHuih0n6bheCogW_66N_79Zhc34L1iBzWq0v5hFxN1vW8Wh2TXjALjxUCfgC23Av9 |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Questioning+risk+compensation%3A+pre-exposure+prophylaxis+%28PrEP%29+and+sexually+transmitted+infections+among+men+who+have+sex+with+men%2C+capital+region+of+Denmark%2C+2019+to+2022&rft.jtitle=Euro+surveillance+%3A+bulletin+europ%C3%A9en+sur+les+maladies+transmissibles&rft.au=von+Schreeb%2C+Sebastian&rft.au=Pedersen%2C+Susanne+Kriegel&rft.au=Christensen%2C+Hanne&rft.au=J%C3%B8rgsensen%2C+Kristina+Melbardis&rft.date=2024-03-28&rft.issn=1560-7917&rft.volume=29&rft.issue=13&rft_id=info:doi/10.2807%2F1560-7917.ES.2024.29.13.2300451&rft.externalDBID=n%2Fa&rft.externalDocID=10_2807_1560_7917_ES_2024_29_13_2300451 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1560-7917&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1560-7917&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1560-7917&client=summon |