Effects of acute and chronic quercetin administration on methylphenidate-induced hyperlocomotion and oxidative stress

Increases in protein kinase C (PKC) and oxidative stress have been related to mania. Drugs with antioxidant effects or inhibitory actions on PKC may have antimanic effects. The flavonoid quercetin has antioxidant and PKC-inhibiting effects that resemble those of lithium, the first-line treatment for...

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Bibliographic Details
Published in:	Life sciences (1973) Vol. 171; pp. 1 - 8
Main Authors:	Kanazawa, Luiz K.S., Vecchia, Débora D., Wendler, Etiéli M., Hocayen, Palloma de A.S., Beirão, Paulo S., de Mélo, Manuela L., dos Reis Lívero, Francislaine A., Corso, Claudia Rita, Stipp, Maria Carolina, Acco, Alexandra, Andreatini, Roberto
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 15.02.2017 Elsevier BV
Subjects:	Affective disorders Animal models Animals antioxidant activity Antioxidants Behavior, Animal - drug effects Bipolar disorder Brain Brain - drug effects Diazepam Dose-Response Relationship, Drug Glutathione hippocampus Hyperlocomotion Kinases Lipid peroxidation Lithium locomotion Locomotion - drug effects Locomotor activity Male males Mania Manic depression Methylphenidate Methylphenidate - toxicity Mice Neostriatum Oxidative stress Oxidative Stress - drug effects Peroxidation Prefrontal cortex Protein kinase C Quercetin Quercetin - administration & dosage Oxidative stress BD Protein kinase C DTNB PKC Bipolar disorder LPO PFC Quercetin CMC Mania Hyperlocomotion GSH
ISSN:	0024-3205, 1879-0631, 1879-0631
Online Access:	Get full text
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