EZH2 inhibition promotes ANGPTL4/CREB1 to suppress the progression of ulcerative colitis

Enhancer of zeste homolog 2 (EZH2) is associated with ulcerative colitis development. However, the mechanism of EZH2 in ulcerative colitis progression remains unclear. Lipopolysaccharide (LPS)-treated Caco-2 cells and dextran sodium sulfate (DSS)-treated mice were used as model of ulcerative colitis...

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Bibliographic Details
Published in:	Life sciences (1973) Vol. 250; pp. 117553 - 10
Main Authors:	Li, Kun, Yang, Jing, Lei, Xiao-Fei, Li, Shuang-Ling, Yang, Hong-Li, Xu, Chang-Qing, Deng, Li
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01.06.2020 Elsevier BV
Subjects:	Adenosine monophosphate Angiopoietin Angiopoietin-like 4 Protein - metabolism ANGPTL4 Animals Apoptosis Caco-2 Cells Cell Survival Cell viability Chromatin chromatin immunoprecipitation Colitis, Ulcerative - metabolism Colon CREB1 Cyclic AMP Cyclic AMP Response Element-Binding Protein - metabolism Cytokines Damage Dextran Dextrans Disease Progression Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors Enzyme-linked immunosorbent assay EZH2 Flow cytometry histology Homology human cell lines Humans Immunoprecipitation Inflammation Inflammatory bowel disease Inflammatory bowel diseases Inflammatory response Lipopolysaccharides Male Mice Mice, Inbred BALB C Polymerase chain reaction quantitative polymerase chain reaction reverse transcriptase polymerase chain reaction Sodium sulfate Ulcerative colitis Western blotting Inflammatory response CREB1 ANGPTL4 Ulcerative colitis EZH2 Apoptosis
ISSN:	0024-3205, 1879-0631, 1879-0631
Online Access:	Get full text
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