ProstaNet: A Novel Geometric Vector Perceptrons–Graph Neural Network Algorithm for Protein Stability Prediction in Single- and Multiple-Point Mutations with Experimental Validation

Proteins play a critical role in biology and biopharma due to their specificity and minimal side effects. Predicting the effects of mutations on protein stability is vital but experimentally challenging. Deep learning offers an efficient solution to this problem. In the present work, we introduced P...

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Bibliographic Details

Published in:	Research (Washington) Vol. 8; p. 0674
Main Authors:	Liang, Tianjian, Sun, Ze-Yu, Ishima, Rieko, Xie, Xiang-Qun, Xue, Ying, Li, Wei, Feng, Zhiwei
Format:	Journal Article
Language:	English
Published:	United States AAAS 2025 American Association for the Advancement of Science (AAAS)
Subjects:	Artificial Intelligence
ISSN:	2639-5274, 2639-5274
Online Access:	Get full text
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