ProstaNet: A Novel Geometric Vector Perceptrons–Graph Neural Network Algorithm for Protein Stability Prediction in Single- and Multiple-Point Mutations with Experimental Validation

Proteins play a critical role in biology and biopharma due to their specificity and minimal side effects. Predicting the effects of mutations on protein stability is vital but experimentally challenging. Deep learning offers an efficient solution to this problem. In the present work, we introduced P...

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Vydáno v:	Research (Washington) Ročník 8; s. 0674
Hlavní autoři:	Liang, Tianjian, Sun, Ze-Yu, Ishima, Rieko, Xie, Xiang-Qun, Xue, Ying, Li, Wei, Feng, Zhiwei
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States AAAS 2025 American Association for the Advancement of Science (AAAS)
Témata:	Artificial Intelligence
ISSN:	2639-5274, 2639-5274
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