Preparation and in vitro evaluation of folate-receptor-targeted SPION-polymer micelle hybrids for MRI contrast enhancement in cancer imaging

Polymer-SPION hybrids were investigated for receptor-mediated localization in tumour tissue. Superparamagnetic iron oxide nanoparticles (SPIONs) prepared by high-temperature decomposition of iron acetylacetonate were monodisperse (9.27 ± 3.37 nm), with high saturation magnetization of 76.8 emu g(-1)...

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Veröffentlicht in:	Nanotechnology Jg. 24; H. 1; S. 015603
Hauptverfasser:	Mahajan, Shveta, Koul, Veena, Choudhary, Veena, Shishodia, Gauri, Bharti, Alok C
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 11.01.2013
Schlagworte:	Cell Death - drug effects Contrast Media Dextrans - chemical synthesis Dextrans - chemistry Dextrans - toxicity Dextrans - ultrastructure Diagnostic Imaging - methods Endocytosis - drug effects Folate Receptor 1 - metabolism HeLa Cells Humans Intracellular Space - drug effects Intracellular Space - metabolism Magnetic Resonance Imaging Magnetite Nanoparticles - chemistry Magnetite Nanoparticles - toxicity Magnetite Nanoparticles - ultrastructure Micelles Microscopy, Confocal Microscopy, Electron, Transmission Neoplasms - diagnosis Neoplasms - pathology Polymerization Polymers - chemical synthesis Polymers - chemistry Pyrenes - chemistry Spectrophotometry, Ultraviolet X-Ray Diffraction
ISSN:	1361-6528, 1361-6528
Online-Zugang:	Weitere Angaben
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