Effects of CYP2C93 and 13 alleles on the pharmacokinetics and pharmacodynamics of glipizide in healthy Korean subjects

Glipizide is a second-generation sulfonylurea antidiabetic drug. It is principally metabolized to inactive metabolites by genetically polymorphic CYP2C9 enzyme. In this study, we investigated the effects of CYP2C9*3 and *13 variant alleles on the pharmacokinetics and pharmacodynamics of glipizide. T...

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Vydáno v:	Archives of pharmacal research Ročník 45; číslo 2; s. 114 - 121
Hlavní autoři:	Kim, Nam-Tae, Cho, Chang‑Keun, Kang, Pureum, Park, Hye-Jung, Lee, Yun Jeong, Bae, Jung‑Woo, Jang, Choon-Gon, Lee, Seok-Yong
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Seoul Pharmaceutical Society of Korea 01.02.2022 대한약학회
Témata:	Administration, Oral Adult Alleles Asians blood glucose Blood Glucose - metabolism Cytochrome P-450 CYP2C9 - genetics Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - genetics enzymes Female Genetic Predisposition to Disease genotype glipizide Glipizide - blood Glipizide - pharmacokinetics Glipizide - pharmacology Healthy Volunteers Humans hypoglycemic agents Hypoglycemic Agents - blood Hypoglycemic Agents - pharmacokinetics Hypoglycemic Agents - pharmacology insulin Male Medicine metabolites oral administration pharmacodynamics pharmacokinetics Pharmacology/Toxicology Pharmacy Polymorphism, Genetic - drug effects Republic of Korea Research Article Young Adult 약학 Republic of Korea CYP2C9 Genotype Pharmacodynamics Glipizide Pharmacokinetics Genetic polymorphism
ISSN:	0253-6269, 1976-3786, 1976-3786
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