Repurposing antifungals: population pharmacokinetics of itraconazole and hydroxy-itraconazole following administration of a nanocrystal formulation

Abstract Objectives To describe itraconazole and hydroxy-itraconazole pharmacokinetics following intravenous (IV) administration of a previously developed nanocrystal formulation (NCF) in haematopoietic cell transplant (HCT) recipients for prophylaxis of invasive fungal disease. Methods In a prospec...

Full description

Bibliographic Details

Published in:	Journal of antimicrobial chemotherapy Vol. 78; no. 5; pp. 1219 - 1224
Main Authors:	Jansen, Anouk M E, Ter Heine, Rob, Donnelly, J P, Blijlevens, Nicole, Brüggemann, Roger J M
Format:	Journal Article
Language:	English
Published:	US Oxford University Press 03.05.2023
Subjects:	Antifungal Agents - therapeutic use Drug Repositioning Hematopoietic Stem Cell Transplantation Humans Itraconazole Nanoparticles Prospective Studies
ISSN:	0305-7453, 1460-2091, 1460-2091
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!