Thyroglobulin Antibodies are Associated with Symptom Burden in Patients with Hashimoto's Thyroiditis: A Cross-Sectional Study

Background: Hashimoto's thyroiditis (HT) is the most common form of autoimmune thyroid disorders characterized by lower production of thyroid hormones and positivity to autoantibodies to thyroglobulin (TgAb) and/or thyroid peroxidase (TPOAb). We performed a comprehensive phenotypic characteriza...

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Published in:Immunological investigations Vol. 48; no. 2; pp. 198 - 209
Main Authors: Barić, Ana, Brčić, Luka, Gračan, Sanda, Škrabić, Veselin, Brekalo, Marko, Šimunac, Marta, Lovrić, Vesela Torlak, Anić, Iva, Barbalić, Maja, Zemunik, Tatijana, Punda, Ante, Boraska Perica, Vesna
Format: Journal Article
Language:English
Published: England Taylor & Francis 17.02.2019
Subjects:
Antibody to thyroglobulin (TgAb)
Autoantibodies - immunology
Biomarkers
Cross-Sectional Studies
Female
Hashimoto Disease - diagnosis
Hashimoto Disease - epidemiology
Hashimoto Disease - etiology
Hashimoto's thyroiditis
Humans
Male
Phenotype
Prognosis
subclinical hypothyroidism
symptoms
Thyroglobulin - immunology
thyroid autoimmunity
symptoms
Hashimoto’s thyroiditis
thyroid autoimmunity
subclinical hypothyroidism
Antibody to thyroglobulin (TgAb)
ISSN:0882-0139, 1532-4311, 1532-4311
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Abstract Background: Hashimoto's thyroiditis (HT) is the most common form of autoimmune thyroid disorders characterized by lower production of thyroid hormones and positivity to autoantibodies to thyroglobulin (TgAb) and/or thyroid peroxidase (TPOAb). We performed a comprehensive phenotypic characterization of patients with HT, with specific focus on thyroid autoimmunity, to get better understanding of disease manifestation. Methods: We collected information on thyroid-specific phenotypes (TSH, T3, T4, fT4, TgAb, TPOAb, thyroid volume) and other clinical phenotypes (age, body surface area, number of hypothyroidism symptoms, blood pressure) from 290 patients with HT without levothyroxine (LT4) therapy with the aim to test for correlations between thyroid-specific and clinical phenotypes. Results: Our key and novel finding is the existence of significant positive correlation between TgAb levels and the number of symptoms (r = 0.25, p = 0.0001) in HT patients without LT4 therapy that remained significant after adjustment for TPOAb, T3, TSH levels and thyroid volume (β = 0.66, SE = 0.3, p = 0.0299). Increased TgAb levels are significantly associated with fragile hair (p = 0.0043), face edema (p = 0.0061), edema of the eyes (p = 0.0293) and harsh voice (p = 0.0349). Conclusions: Elevated TgAb levels are associated with symptom burden in HT patients, suggesting a role of thyroid autoimmunity in clinical manifestations of HT. Based on these results, we recommend screening for TgAb antibodies in HT patients with symptom burden. We also suggest that further work on understandings of symptoms appearance due to their autoimmune or hypothyroid causation is needed.
AbstractList Background: Hashimoto's thyroiditis (HT) is the most common form of autoimmune thyroid disorders characterized by lower production of thyroid hormones and positivity to autoantibodies to thyroglobulin (TgAb) and/or thyroid peroxidase (TPOAb). We performed a comprehensive phenotypic characterization of patients with HT, with specific focus on thyroid autoimmunity, to get better understanding of disease manifestation. Methods: We collected information on thyroid-specific phenotypes (TSH, T3, T4, fT4, TgAb, TPOAb, thyroid volume) and other clinical phenotypes (age, body surface area, number of hypothyroidism symptoms, blood pressure) from 290 patients with HT without levothyroxine (LT4) therapy with the aim to test for correlations between thyroid-specific and clinical phenotypes. Results: Our key and novel finding is the existence of significant positive correlation between TgAb levels and the number of symptoms (r = 0.25, p = 0.0001) in HT patients without LT4 therapy that remained significant after adjustment for TPOAb, T3, TSH levels and thyroid volume (β = 0.66, SE = 0.3, p = 0.0299). Increased TgAb levels are significantly associated with fragile hair (p = 0.0043), face edema (p = 0.0061), edema of the eyes (p = 0.0293) and harsh voice (p = 0.0349). Conclusions: Elevated TgAb levels are associated with symptom burden in HT patients, suggesting a role of thyroid autoimmunity in clinical manifestations of HT. Based on these results, we recommend screening for TgAb antibodies in HT patients with symptom burden. We also suggest that further work on understandings of symptoms appearance due to their autoimmune or hypothyroid causation is needed.
Hashimoto's thyroiditis (HT) is the most common form of autoimmune thyroid disorders characterized by lower production of thyroid hormones and positivity to autoantibodies to thyroglobulin (TgAb) and/or thyroid peroxidase (TPOAb). We performed a comprehensive phenotypic characterization of patients with HT, with specific focus on thyroid autoimmunity, to get better understanding of disease manifestation. We collected information on thyroid-specific phenotypes (TSH, T3, T4, fT4, TgAb, TPOAb, thyroid volume) and other clinical phenotypes (age, body surface area, number of hypothyroidism symptoms, blood pressure) from 290 patients with HT without levothyroxine (LT4) therapy with the aim to test for correlations between thyroid-specific and clinical phenotypes. Our key and novel finding is the existence of significant positive correlation between TgAb levels and the number of symptoms (r = 0.25, p = 0.0001) in HT patients without LT4 therapy that remained significant after adjustment for TPOAb, T3, TSH levels and thyroid volume (β = 0.66, SE = 0.3, p = 0.0299). Increased TgAb levels are significantly associated with fragile hair (p = 0.0043), face edema (p = 0.0061), edema of the eyes (p = 0.0293) and harsh voice (p = 0.0349). Elevated TgAb levels are associated with symptom burden in HT patients, suggesting a role of thyroid autoimmunity in clinical manifestations of HT. Based on these results, we recommend screening for TgAb antibodies in HT patients with symptom burden. We also suggest that further work on understandings of symptoms appearance due to their autoimmune or hypothyroid causation is needed.
Hashimoto's thyroiditis (HT) is the most common form of autoimmune thyroid disorders characterized by lower production of thyroid hormones and positivity to autoantibodies to thyroglobulin (TgAb) and/or thyroid peroxidase (TPOAb). We performed a comprehensive phenotypic characterization of patients with HT, with specific focus on thyroid autoimmunity, to get better understanding of disease manifestation.BACKGROUNDHashimoto's thyroiditis (HT) is the most common form of autoimmune thyroid disorders characterized by lower production of thyroid hormones and positivity to autoantibodies to thyroglobulin (TgAb) and/or thyroid peroxidase (TPOAb). We performed a comprehensive phenotypic characterization of patients with HT, with specific focus on thyroid autoimmunity, to get better understanding of disease manifestation.We collected information on thyroid-specific phenotypes (TSH, T3, T4, fT4, TgAb, TPOAb, thyroid volume) and other clinical phenotypes (age, body surface area, number of hypothyroidism symptoms, blood pressure) from 290 patients with HT without levothyroxine (LT4) therapy with the aim to test for correlations between thyroid-specific and clinical phenotypes.METHODSWe collected information on thyroid-specific phenotypes (TSH, T3, T4, fT4, TgAb, TPOAb, thyroid volume) and other clinical phenotypes (age, body surface area, number of hypothyroidism symptoms, blood pressure) from 290 patients with HT without levothyroxine (LT4) therapy with the aim to test for correlations between thyroid-specific and clinical phenotypes.Our key and novel finding is the existence of significant positive correlation between TgAb levels and the number of symptoms (r = 0.25, p = 0.0001) in HT patients without LT4 therapy that remained significant after adjustment for TPOAb, T3, TSH levels and thyroid volume (β = 0.66, SE = 0.3, p = 0.0299). Increased TgAb levels are significantly associated with fragile hair (p = 0.0043), face edema (p = 0.0061), edema of the eyes (p = 0.0293) and harsh voice (p = 0.0349).RESULTSOur key and novel finding is the existence of significant positive correlation between TgAb levels and the number of symptoms (r = 0.25, p = 0.0001) in HT patients without LT4 therapy that remained significant after adjustment for TPOAb, T3, TSH levels and thyroid volume (β = 0.66, SE = 0.3, p = 0.0299). Increased TgAb levels are significantly associated with fragile hair (p = 0.0043), face edema (p = 0.0061), edema of the eyes (p = 0.0293) and harsh voice (p = 0.0349).Elevated TgAb levels are associated with symptom burden in HT patients, suggesting a role of thyroid autoimmunity in clinical manifestations of HT. Based on these results, we recommend screening for TgAb antibodies in HT patients with symptom burden. We also suggest that further work on understandings of symptoms appearance due to their autoimmune or hypothyroid causation is needed.CONCLUSIONSElevated TgAb levels are associated with symptom burden in HT patients, suggesting a role of thyroid autoimmunity in clinical manifestations of HT. Based on these results, we recommend screening for TgAb antibodies in HT patients with symptom burden. We also suggest that further work on understandings of symptoms appearance due to their autoimmune or hypothyroid causation is needed.
Author Brekalo, Marko
Punda, Ante
Anić, Iva
Boraska Perica, Vesna
Lovrić, Vesela Torlak
Gračan, Sanda
Barić, Ana
Škrabić, Veselin
Barbalić, Maja
Zemunik, Tatijana
Šimunac, Marta
Brčić, Luka
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  organization: Department of Medical Biology, University of Split, School of Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30332318$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/S0301-0546(02)79087-3
10.1001/archinte.160.4.526
10.1530/EJE-15-1061
10.1089/thy.2010.0191
10.1159/000358873
10.1093/clinchem/35.9.1949
10.1001/archinte.168.6.587
10.1136/ard.2004.022624
10.1089/rej.2017.1991
10.1016/j.amjsurg.2013.05.005
10.1586/1744666X.4.2.221
10.1089/thy.2011.0100
10.1210/jc.2006-2208
10.1210/jcem.87.7.8678
10.3389/fendo.2017.00290
10.1111/cen.12471
10.1080/08916934.2016.1191475
10.1007/BF03343925
10.1016/j.jtbi.2014.12.015
10.1016/S0140-6736(17)30703-1
10.1210/jcem.83.9.5131
10.3109/00016489.2015.1021932
10.1046/j.1365-2265.2000.00939.x
10.1007/BF03347031
10.1007/s11011-017-0076-3
10.1159/000356507
10.5603/EP.2015.0049
10.4158/EP161635.RA
10.1016/j.jaut.2015.07.009
10.1146/annurev-pathol-012513-104713
10.1016/j.kjms.2016.06.006
10.1530/EJE-11-0261
10.1684/ejd.2012.1711
10.1111/j.1365-2265.1995.tb01894.x
10.3389/fimmu.2017.00521
10.1210/jc.2011-3020
10.1097/MED.0000000000000355
10.1159/000371346
10.1371/journal.pone.0034979
10.1038/nrendo.2013.56
10.1080/08820139.2017.1337785
10.5114/ada.2017.72464
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Issue 2
Keywords symptoms
Hashimoto’s thyroiditis
thyroid autoimmunity
subclinical hypothyroidism
Antibody to thyroglobulin (TgAb)
Language English
License open-access: http://creativecommons.org/licenses/by-nc-nd/4.0/: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
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References CIT0030
CIT0010
CIT0032
CIT0031
CIT0012
CIT0034
CIT0011
CIT0033
Bastemir M. (CIT0006) 2007; 137
CIT0014
CIT0013
CIT0035
CIT0016
CIT0038
CIT0015
CIT0037
CIT0018
CIT0017
CIT0039
CIT0019
CIT0041
CIT0040
CIT0021
CIT0043
CIT0020
Schiemann U. (CIT0036) 2003; 9
CIT0042
CIT0023
CIT0045
CIT0022
CIT0044
Altamirano Ufion A. (CIT0001) 2017; 7539735
CIT0003
CIT0025
CIT0002
CIT0024
CIT0005
Beever K. (CIT0007) 1989; 35
CIT0027
CIT0004
CIT0026
CIT0029
CIT0028
CIT0009
CIT0008
References_xml – ident: CIT0028
  doi: 10.1016/S0301-0546(02)79087-3
– ident: CIT0012
  doi: 10.1001/archinte.160.4.526
– volume: 137
  start-page: 431
  issue: 29
  year: 2007
  ident: CIT0006
  publication-title: Swiss Med Wkly
– ident: CIT0003
  doi: 10.1530/EJE-15-1061
– ident: CIT0030
  doi: 10.1089/thy.2010.0191
– ident: CIT0025
  doi: 10.1159/000358873
– volume: 9
  start-page: MT13
  issue: 4
  year: 2003
  ident: CIT0036
  publication-title: Med Sci Monit
– volume: 35
  start-page: 1949
  issue: 9
  year: 1989
  ident: CIT0007
  publication-title: Clin Chem
  doi: 10.1093/clinchem/35.9.1949
– ident: CIT0020
  doi: 10.1001/archinte.168.6.587
– ident: CIT0040
  doi: 10.1136/ard.2004.022624
– ident: CIT0019
  doi: 10.1089/rej.2017.1991
– ident: CIT0033
  doi: 10.1016/j.amjsurg.2013.05.005
– ident: CIT0039
  doi: 10.1586/1744666X.4.2.221
– ident: CIT0017
  doi: 10.1089/thy.2011.0100
– ident: CIT0002
  doi: 10.1210/jc.2006-2208
– ident: CIT0022
  doi: 10.1210/jcem.87.7.8678
– ident: CIT0004
  doi: 10.3389/fendo.2017.00290
– ident: CIT0015
  doi: 10.1111/cen.12471
– ident: CIT0009
  doi: 10.1080/08916934.2016.1191475
– ident: CIT0034
  doi: 10.1007/BF03343925
– ident: CIT0027
  doi: 10.1016/j.jtbi.2014.12.015
– ident: CIT0013
  doi: 10.1016/S0140-6736(17)30703-1
– ident: CIT0032
  doi: 10.1210/jcem.83.9.5131
– ident: CIT0035
  doi: 10.3109/00016489.2015.1021932
– volume: 7539735
  start-page: 28
  issue: 10
  year: 2017
  ident: CIT0001
  publication-title: Cardiol Res Pract
– ident: CIT0005
  doi: 10.1046/j.1365-2265.2000.00939.x
– ident: CIT0045
  doi: 10.1007/BF03347031
– ident: CIT0029
  doi: 10.1007/s11011-017-0076-3
– ident: CIT0031
  doi: 10.1159/000356507
– ident: CIT0037
  doi: 10.5603/EP.2015.0049
– ident: CIT0014
  doi: 10.4158/EP161635.RA
– ident: CIT0026
  doi: 10.1016/j.jaut.2015.07.009
– ident: CIT0041
  doi: 10.1146/annurev-pathol-012513-104713
– ident: CIT0008
  doi: 10.1016/j.kjms.2016.06.006
– ident: CIT0018
  doi: 10.1530/EJE-11-0261
– ident: CIT0043
  doi: 10.1684/ejd.2012.1711
– ident: CIT0044
  doi: 10.1111/j.1365-2265.1995.tb01894.x
– ident: CIT0021
  doi: 10.3389/fimmu.2017.00521
– ident: CIT0011
  doi: 10.1210/jc.2011-3020
– ident: CIT0023
  doi: 10.1097/MED.0000000000000355
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Snippet Background: Hashimoto's thyroiditis (HT) is the most common form of autoimmune thyroid disorders characterized by lower production of thyroid hormones and...
Hashimoto's thyroiditis (HT) is the most common form of autoimmune thyroid disorders characterized by lower production of thyroid hormones and positivity to...
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SubjectTerms Antibody to thyroglobulin (TgAb)
Autoantibodies - immunology
Biomarkers
Cross-Sectional Studies
Female
Hashimoto Disease - diagnosis
Hashimoto Disease - epidemiology
Hashimoto Disease - etiology
Hashimoto's thyroiditis
Humans
Male
Phenotype
Prognosis
subclinical hypothyroidism
symptoms
Thyroglobulin - immunology
thyroid autoimmunity
Title Thyroglobulin Antibodies are Associated with Symptom Burden in Patients with Hashimoto's Thyroiditis: A Cross-Sectional Study
URI https://www.tandfonline.com/doi/abs/10.1080/08820139.2018.1529040
https://www.ncbi.nlm.nih.gov/pubmed/30332318
https://www.proquest.com/docview/2122592931
Volume 48
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