Autoantibodies in neuromuscular disorders: a review of their utility in clinical practice

A great proportion of neuromuscular diseases are immune-mediated, included myasthenia gravis, Lambert-Eaton myasthenic syndrome, acute- and chronic-onset autoimmune neuropathies (anti-MAG neuropathy, multifocal motor neuropathy, Guillain-Barré syndromes, chronic inflammatory demyelinating polyradicu...

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Bibliographic Details
Published in:Frontiers in neurology Vol. 15; p. 1495205
Main Authors: Loser, Valentin, Vicino, Alex, Théaudin, Marie
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 01.11.2024
Subjects:
autoantibodies
clinical practice
detection method
neuromuscular diseases
review
clinical practice
neuromuscular diseases
autoantibodies
detection method
review
ISSN:1664-2295, 1664-2295
Online Access:Get full text
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Summary:A great proportion of neuromuscular diseases are immune-mediated, included myasthenia gravis, Lambert-Eaton myasthenic syndrome, acute- and chronic-onset autoimmune neuropathies (anti-MAG neuropathy, multifocal motor neuropathy, Guillain-Barré syndromes, chronic inflammatory demyelinating polyradiculoneuropathy, CANDA and autoimmune nodopathies), autoimmune neuronopathies, peripheral nerve hyperexcitability syndromes and idiopathic inflammatory myopathies. The detection of autoantibodies against neuromuscular structures has many diagnostic and therapeutic implications and, over time, allowed a better understanding of the physiopathology of those disorders. In this paper, we will review the main autoantibodies described in neuromuscular diseases and focus on their use in clinical practice.
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ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2024.1495205