Effect of a Nutritional Supplement Containing Vitamin E, Selenium, Vitamin C and Coenzyme Q10 on Serum PSA in Patients with Hormonally Untreated Carcinoma of the Prostate: A Randomised Placebo-Controlled Study

To assess the effect of a nutritional supplement containing vitamin E, selenium, vitamin C and coenzyme Q10 on changes in serum levels of PSA in patients with hormonally untreated carcinoma of the prostate and rising serum PSA levels. Eighty patients were randomised to receive a daily supplement wit...

Full description

Saved in:

Bibliographic Details
Published in:	European urology Vol. 47; no. 4; pp. 433 - 440
Main Authors:	Hoenjet, K.M.J.L.F., Dagnelie, P.C., Delaere, K.P.J., Wijckmans, N.E.G., Zambon, J.V., Oosterhof, G.O.N.
Format:	Journal Article
Language:	English
Published:	Switzerland Elsevier B.V 01.04.2005
Subjects:	Aged Aged, 80 and over Anti-oxidants Ascorbic Acid - therapeutic use Coenzyme Q10 Coenzymes Dietary Supplements Double-Blind Method Drug Therapy, Combination Hormones Humans Male Middle Aged Nutrition Prostate cancer Prostate-Specific Antigen - blood Prostatic Neoplasms - blood Prostatic Neoplasms - drug therapy PSA Selenium Selenium - therapeutic use Ubiquinone - analogs & derivatives Ubiquinone - therapeutic use Vitamin C Vitamin E Vitamin E - therapeutic use Anti-oxidants Nutrition Vitamin E Coenzyme Q10 Vitamin C Selenium Prostate cancer PSA
ISSN:	0302-2838, 1873-7560
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	To assess the effect of a nutritional supplement containing vitamin E, selenium, vitamin C and coenzyme Q10 on changes in serum levels of PSA in patients with hormonally untreated carcinoma of the prostate and rising serum PSA levels. Eighty patients were randomised to receive a daily supplement with either vitamin E, selenium, vitamin C, coenzyme Q10 (intervention group) or placebo over 21 weeks. Serum levels of PSA were assessed at baseline (−2, −1, 0 weeks) and after 6, 13, 19, 20 and 21 weeks. Mean changes in log serum level of PSA, testosterone, dihydrotestosterone, luteinizing hormone and sex hormone binding globulin over 21 weeks between the verum and the placebo group were compared by analysis of covariance. Seventy patients completed the study (36 verum; 34 placebo). Compliance was >90% in all patients. In the intervention group, plasma levels of vitamin E, selenium and coenzyme Q10 increased significantly over the 21 weeks study period. No significant differences in serum levels of PSA, testosterone, dihydrotestosterone, luteinizing hormone or sex hormone binding globulin ( p > 0.2) were observed between the intervention and control group. Our results indicate that supplementation of a combination of vitamin E, selenium, vitamin C and coenzyme-Q10 does not affect serum level of PSA or hormone levels in patients with hormonally untreated carcinoma of the prostate.
AbstractList	To assess the effect of a nutritional supplement containing vitamin E, selenium, vitamin C and coenzyme Q10 on changes in serum levels of PSA in patients with hormonally untreated carcinoma of the prostate and rising serum PSA levels.OBJECTIVETo assess the effect of a nutritional supplement containing vitamin E, selenium, vitamin C and coenzyme Q10 on changes in serum levels of PSA in patients with hormonally untreated carcinoma of the prostate and rising serum PSA levels.Eighty patients were randomised to receive a daily supplement with either vitamin E, selenium, vitamin C, coenzyme Q10 (intervention group) or placebo over 21 weeks. Serum levels of PSA were assessed at baseline (-2, -1, 0 weeks) and after 6, 13, 19, 20 and 21 weeks. Mean changes in log serum level of PSA, testosterone, dihydrotestosterone, luteinizing hormone and sex hormone binding globulin over 21 weeks between the verum and the placebo group were compared by analysis of covariance.METHODSEighty patients were randomised to receive a daily supplement with either vitamin E, selenium, vitamin C, coenzyme Q10 (intervention group) or placebo over 21 weeks. Serum levels of PSA were assessed at baseline (-2, -1, 0 weeks) and after 6, 13, 19, 20 and 21 weeks. Mean changes in log serum level of PSA, testosterone, dihydrotestosterone, luteinizing hormone and sex hormone binding globulin over 21 weeks between the verum and the placebo group were compared by analysis of covariance.Seventy patients completed the study (36 verum; 34 placebo). Compliance was >90% in all patients. In the intervention group, plasma levels of vitamin E, selenium and coenzyme Q10 increased significantly over the 21 weeks study period. No significant differences in serum levels of PSA, testosterone, dihydrotestosterone, luteinizing hormone or sex hormone binding globulin (p>0.2) were observed between the intervention and control group.RESULTSSeventy patients completed the study (36 verum; 34 placebo). Compliance was >90% in all patients. In the intervention group, plasma levels of vitamin E, selenium and coenzyme Q10 increased significantly over the 21 weeks study period. No significant differences in serum levels of PSA, testosterone, dihydrotestosterone, luteinizing hormone or sex hormone binding globulin (p>0.2) were observed between the intervention and control group.Our results indicate that supplementation of a combination of vitamin E, selenium, vitamin C and coenzyme-Q10 does not affect serum level of PSA or hormone levels in patients with hormonally untreated carcinoma of the prostate.CONCLUSIONOur results indicate that supplementation of a combination of vitamin E, selenium, vitamin C and coenzyme-Q10 does not affect serum level of PSA or hormone levels in patients with hormonally untreated carcinoma of the prostate. To assess the effect of a nutritional supplement containing vitamin E, selenium, vitamin C and coenzyme Q10 on changes in serum levels of PSA in patients with hormonally untreated carcinoma of the prostate and rising serum PSA levels. Eighty patients were randomised to receive a daily supplement with either vitamin E, selenium, vitamin C, coenzyme Q10 (intervention group) or placebo over 21 weeks. Serum levels of PSA were assessed at baseline (−2, −1, 0 weeks) and after 6, 13, 19, 20 and 21 weeks. Mean changes in log serum level of PSA, testosterone, dihydrotestosterone, luteinizing hormone and sex hormone binding globulin over 21 weeks between the verum and the placebo group were compared by analysis of covariance. Seventy patients completed the study (36 verum; 34 placebo). Compliance was >90% in all patients. In the intervention group, plasma levels of vitamin E, selenium and coenzyme Q10 increased significantly over the 21 weeks study period. No significant differences in serum levels of PSA, testosterone, dihydrotestosterone, luteinizing hormone or sex hormone binding globulin ( p > 0.2) were observed between the intervention and control group. Our results indicate that supplementation of a combination of vitamin E, selenium, vitamin C and coenzyme-Q10 does not affect serum level of PSA or hormone levels in patients with hormonally untreated carcinoma of the prostate. To assess the effect of a nutritional supplement containing vitamin E, selenium, vitamin C and coenzyme Q10 on changes in serum levels of PSA in patients with hormonally untreated carcinoma of the prostate and rising serum PSA levels. Eighty patients were randomised to receive a daily supplement with either vitamin E, selenium, vitamin C, coenzyme Q10 (intervention group) or placebo over 21 weeks. Serum levels of PSA were assessed at baseline (-2, -1, 0 weeks) and after 6, 13, 19, 20 and 21 weeks. Mean changes in log serum level of PSA, testosterone, dihydrotestosterone, luteinizing hormone and sex hormone binding globulin over 21 weeks between the verum and the placebo group were compared by analysis of covariance. Seventy patients completed the study (36 verum; 34 placebo). Compliance was >90% in all patients. In the intervention group, plasma levels of vitamin E, selenium and coenzyme Q10 increased significantly over the 21 weeks study period. No significant differences in serum levels of PSA, testosterone, dihydrotestosterone, luteinizing hormone or sex hormone binding globulin (p>0.2) were observed between the intervention and control group. Our results indicate that supplementation of a combination of vitamin E, selenium, vitamin C and coenzyme-Q10 does not affect serum level of PSA or hormone levels in patients with hormonally untreated carcinoma of the prostate.
Author	Delaere, K.P.J. Wijckmans, N.E.G. Hoenjet, K.M.J.L.F. Zambon, J.V. Dagnelie, P.C. Oosterhof, G.O.N.
Author_xml	– sequence: 1 givenname: K.M.J.L.F. surname: Hoenjet fullname: Hoenjet, K.M.J.L.F. organization: Department of Urology, University Hospital of Maastricht, P. Debeyelaan 25, 6202 AZ Maastricht, The Netherlands – sequence: 2 givenname: P.C. surname: Dagnelie fullname: Dagnelie, P.C. organization: Department of Epidemiology, Maastricht University, Maastricht, The Netherlands – sequence: 3 givenname: K.P.J. surname: Delaere fullname: Delaere, K.P.J. organization: Atrium Medical Centre, Heerlen, The Netherlands – sequence: 4 givenname: N.E.G. surname: Wijckmans fullname: Wijckmans, N.E.G. organization: Department of Epidemiology, Maastricht University, Maastricht, The Netherlands – sequence: 5 givenname: J.V. surname: Zambon fullname: Zambon, J.V. organization: Maasland Hospital, Sittard, The Netherlands – sequence: 6 givenname: G.O.N. surname: Oosterhof fullname: Oosterhof, G.O.N. email: G.Oosterhof@urology.azm.nl organization: Department of Urology, University Hospital of Maastricht, P. Debeyelaan 25, 6202 AZ Maastricht, The Netherlands
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/15774238$$D View this record in MEDLINE/PubMed
BookMark	eNqFktFu0zAUhi00xLrBGyDkK66WYsdJnExoUlUVhjRBoYxby3VOmItjF8cGhbfkjXDUAdJuemXp-Pv_c-z_nKET6ywg9JySOSW0erWbQ_TRu3lOSDGndE4of4RmtOYs42VFTtCMMJJnec3qU3Q2DDtCCCsb9gSd0pLzImf1DP1edR2ogF2HJX4fg9dBOysN3sT93kAPNuCls0Fqq-1X_EUH2WuLVxd4Awasjv3Fv-ISS9smGuyvsQf8kRLsbOJ87PF6s8AJWcugk-WAf-pwh6-d76dmZsS3NniQAZJeeqWt6-U0U7gDvPZuCOnqEi_wp9TB9XpI3NpIBVuXTdN5Z0wqbUJsx6focSfNAM_uz3N0-2b1eXmd3Xx4-265uMlUQVnI2gKgILSRNS1lXcuSNYqrBhSryhok6woqK961jJUyr7qcK96UXZOut0VF65ado5cH37133yMMQaS5FBgjLbg4iIqXecFZnsAX92Dc9tCKvde99KP4G0ICigOg0ksHD91_hIgpa7ETh6zFlLWgVKSsk-zygUylIKb4gpfaHBNfHcSQvuiHBi8GlZJR0Gqf9kG0Th8zeP3AQJm0I0qabzAel_8By73erA
CitedBy_id	crossref_primary_10_1111_j_1753_4887_2007_tb00317_x crossref_primary_10_1016_j_explore_2009_12_008 crossref_primary_10_1016_j_currproblcancer_2024_101063 crossref_primary_10_3390_biom8040172 crossref_primary_10_1017_S0007114512004783 crossref_primary_10_1097_CMR_0b013e32818867a0 crossref_primary_10_1016_j_maturitas_2013_03_006 crossref_primary_10_3109_13685538_2015_1017809 crossref_primary_10_1155_2022_6768139 crossref_primary_10_1007_s11934_008_0038_8 crossref_primary_10_1007_s10552_015_0659_4 crossref_primary_10_3390_nu14204383 crossref_primary_10_3390_ijms151120169 crossref_primary_10_1080_10408398_2022_2137724 crossref_primary_10_1080_01635581_2023_2295578 crossref_primary_10_1517_13543781003727495 crossref_primary_10_3390_nu13051697 crossref_primary_10_1016_j_pcl_2007_10_007 crossref_primary_10_1111_j_1742_7843_2007_00065_x crossref_primary_10_3390_nu12102985 crossref_primary_10_3390_nu12051457 crossref_primary_10_1016_S0210_4806_09_74225_1 crossref_primary_10_1038_s41598_021_84301_x crossref_primary_10_1111_j_1440_1827_2007_02182_x crossref_primary_10_1111_j_1365_277X_2009_00946_x crossref_primary_10_14694_EdBook_AM_2014_34_e478
Cites_doi	10.1093/ajcn/76.4.703 10.1111/j.1464-410X.2004.04795.x 10.1080/07315724.1999.10718822 10.1006/bbrc.1997.6522 10.1002/(SICI)1097-0215(19960410)66:2<145::AID-IJC1>3.0.CO;2-2 10.1158/1535-7163.605.3.5 10.1093/jnci/90.16.1219 10.1093/jnci/90.6.440 10.1016/S0140-6736(03)12713-4 10.1002/pros.10184 10.1080/01635589209514179 10.1002/biof.5520090237 10.1001/jama.276.24.1957
ContentType	Journal Article
Copyright	2004 Elsevier B.V.
Copyright_xml	– notice: 2004 Elsevier B.V.
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1016/j.eururo.2004.11.017
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1873-7560
EndPage	440
ExternalDocumentID	15774238 10_1016_j_eururo_2004_11_017 S0302283804006256
Genre	Clinical Trial Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- --K --M .1- .55 .FO .GJ .~1 0R~ 0~B 1B1 1P~ 1~. 1~5 29G 30W 34G 39C 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 8UI AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AATTM AAXKI AAXUO AAYIC AAYWO ABBQC ABBTS ABFNM ABJNI ABLJU ABMAC ABMZM ABOCM ABWCG ABWVN ABXDB ACDAQ ACIEU ACLOT ACQXL ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO AEBSH AEIPS AEKER AENEX AEUPX AEVXI AEYAO AFJKZ AFPUW AFRHN AFSIO AFTJW AFXIZ AGHFR AGUBO AGYEJ AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP AXJTR BKOJK BLXMC BNPGV CAG COF CS3 CYUIP DU5 E0A EBS EFJIC EFKBS EFLBG EJD EO8 EO9 EP2 EP3 F5P FB. FDB FEDTE FIRID FNPLU FYGXN G-Q GBLVA HVGLF HZ~ IHE J1W KOM M41 MO0 N9A O-L O1H O9- OAUVE OK. OW. OZT P-8 P-9 P2P PC. Q38 RKO ROL RPZ SCC SDF SDG SEL SES SEW SPCBC SSH SSZ T5K UDS UJ6 UV1 X7M Z5R ZGI ZXP ~G- ~HD AACTN AAIAV ABLVK ABYKQ AFCTW AFKWA AHPSJ AJBFU AJOXV AMFUW AZPMC LCYCR RIG ZA5 9DU AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8
ID	FETCH-LOGICAL-c413t-d4ee4019a815a88a539c7c9ec3658ea3f41a67fd335a26f27c795f9c36b4618d3
ISICitedReferencesCount	33
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000228121500002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0302-2838
IngestDate	Sun Nov 09 11:32:23 EST 2025 Wed Feb 19 01:40:08 EST 2025 Sat Nov 29 03:50:43 EST 2025 Tue Nov 18 22:23:31 EST 2025 Fri Feb 23 02:25:32 EST 2024 Tue Oct 14 19:35:27 EDT 2025
IsPeerReviewed	true
IsScholarly	true
Issue	4
Keywords	Anti-oxidants Nutrition Vitamin E Coenzyme Q10 Vitamin C Selenium Prostate cancer PSA
Language	English
License	https://www.elsevier.com/tdm/userlicense/1.0
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c413t-d4ee4019a815a88a539c7c9ec3658ea3f41a67fd335a26f27c795f9c36b4618d3
Notes	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3
PMID	15774238
PQID	67524732
PQPubID	23479
PageCount	8
ParticipantIDs	proquest_miscellaneous_67524732 pubmed_primary_15774238 crossref_primary_10_1016_j_eururo_2004_11_017 crossref_citationtrail_10_1016_j_eururo_2004_11_017 elsevier_sciencedirect_doi_10_1016_j_eururo_2004_11_017 elsevier_clinicalkey_doi_10_1016_j_eururo_2004_11_017
PublicationCentury	2000
PublicationDate	2005-04-01
PublicationDateYYYYMMDD	2005-04-01
PublicationDate_xml	– month: 04 year: 2005 text: 2005-04-01 day: 01
PublicationDecade	2000
PublicationPlace	Switzerland
PublicationPlace_xml	– name: Switzerland
PublicationTitle	European urology
PublicationTitleAlternate	Eur Urol
PublicationYear	2005
Publisher	Elsevier B.V
Publisher_xml	– name: Elsevier B.V
References	Judy, Willis, Folkers (bib10) 1998 Heinonen, Albanes, Virtamo, Taylor, Huttunen, Hartman (bib5) 1998; 90 Gronberg (bib1) 2003; 361 Prasad, Kumar, Kochupillai, Cole (bib21) 1999; 18 Brigelius Flohe, Kelly, Salonen, Neuzil, Zingg, Azzi (bib15) 2002; 76 Eichholzer, Stahelin, Gey, Ludin, Bernasconi (bib17) 1996; 66 Cho, Jiang, Malewicz, Dong, Young, Kang (bib19) 2004; 3 Bhamre, Whitin, Cohen (bib20) 2003; 54 Folkers, Osterborg, Nylander, Morita, Mellstedt (bib9) 1997; 234 NEVO Foundation. Dutch food composition table. The Hague: Netherlands Bureau for Nutrition Education; 2001. Hodges, Hertz, Lockwood, Lister (bib22) 1999; 9 Griffiths, Adlercreutz, Boyle, Denis, Nicholson, Morton (bib2) 1996 Thompson, Albanes, Griffiths, Klein, Lucia, Oosterhof (bib3) 2003 Clark, Combs, Turnbull, Slate, Chalker, Chow (bib6) 1996; 276 Prasad, Kumar, Kochupillai, Cole (bib7) 1999; 18 Dagnelie, Schuurman, Goldbohm, Van den Brandt (bib4) 2004; 93 Schröder, Dijk, Blom, Tijburg, Weststrate, Dagnelie (bib8) 2000; 37 Takada, Hirooka, Hatano, Hamada, Yamamoto (bib11) 1992; 17 Hercberg, Galan, Preziosi, Roussel, Arnaud, Richard (bib12) 1998; 68 Donders-Engelen (bib13) 1997 Nixon, Lilly, Liedtke, Batjer (bib16) 1997; 121 Yoshizawa, Willett, Morris, Stampfer, Spiegelman, Rimm (bib18) 1998; 90 Cho (10.1016/j.eururo.2004.11.017_bib19) 2004; 3 Yoshizawa (10.1016/j.eururo.2004.11.017_bib18) 1998; 90 Dagnelie (10.1016/j.eururo.2004.11.017_bib4) 2004; 93 Schröder (10.1016/j.eururo.2004.11.017_bib8) 2000; 37 Eichholzer (10.1016/j.eururo.2004.11.017_bib17) 1996; 66 Clark (10.1016/j.eururo.2004.11.017_bib6) 1996; 276 Heinonen (10.1016/j.eururo.2004.11.017_bib5) 1998; 90 Hercberg (10.1016/j.eururo.2004.11.017_bib12) 1998; 68 Folkers (10.1016/j.eururo.2004.11.017_bib9) 1997; 234 Gronberg (10.1016/j.eururo.2004.11.017_bib1) 2003; 361 Takada (10.1016/j.eururo.2004.11.017_bib11) 1992; 17 Brigelius Flohe (10.1016/j.eururo.2004.11.017_bib15) 2002; 76 Thompson (10.1016/j.eururo.2004.11.017_bib3) 2003 Nixon (10.1016/j.eururo.2004.11.017_bib16) 1997; 121 Bhamre (10.1016/j.eururo.2004.11.017_bib20) 2003; 54 Prasad (10.1016/j.eururo.2004.11.017_bib21) 1999; 18 Hodges (10.1016/j.eururo.2004.11.017_bib22) 1999; 9 Griffiths (10.1016/j.eururo.2004.11.017_bib2) 1996 Prasad (10.1016/j.eururo.2004.11.017_bib7) 1999; 18 Donders-Engelen (10.1016/j.eururo.2004.11.017_bib13) 1997 Judy (10.1016/j.eururo.2004.11.017_bib10) 1998 10.1016/j.eururo.2004.11.017_bib14
References_xml	– year: 1997 ident: bib13 article-title: Portion sizes, weigths and food code numbers – year: 1998 ident: bib10 article-title: Regression of prostate cancer and plasma specific antigens (PSA) in patients on treatment with CoQ10 publication-title: Presented at the First Conference of the International Coenzyme Q10 Association – volume: 9 start-page: 365 year: 1999 end-page: 370 ident: bib22 article-title: CoQ10: could it have a role in cancer management? publication-title: Biofactors – volume: 234 start-page: 296 year: 1997 end-page: 299 ident: bib9 article-title: Activities of vitamin Q10 in animal models and a serious deficiency in patients with cancer publication-title: Biochem Biophys Res Commun – volume: 18 start-page: 13 year: 1999 end-page: 25 ident: bib7 article-title: High doses of multiple antioxidant vitamins: essential ingredients in improving the efficacy of standard cancer therapy publication-title: J Am Coll Nutr – start-page: 287 year: 2003 end-page: 322 ident: bib3 article-title: Chemoprevention of prostate cancer publication-title: Prostate cancer – volume: 121 start-page: 385 year: 1997 end-page: 391 ident: bib16 article-title: Variation of free and total prostate-specific antigen levels: the effect on the percent free/total prostate-specific antigen publication-title: Arch Pathol Lab Med – volume: 93 start-page: 1139 year: 2004 end-page: 1150 ident: bib4 article-title: Diet, anthropometric measures and prostate cancer risk: a review of prospective cohort and intervention studies publication-title: BJU Int – volume: 66 start-page: 145 year: 1996 end-page: 150 ident: bib17 article-title: Prediction of male cancer mortality by plasma levels of interacting vitamins: 17-year follow-up of the prospective Basel study publication-title: Int J Cancer – volume: 68 start-page: 3 year: 1998 end-page: 20 ident: bib12 article-title: Background and rationale behind the SU.VI.MAX Study, a prevention trial using nutritional doses of a combination of antioxidant vitamins and minerals to reduce cardiovascular diseases and cancers. SUpplementation en VItamines et Mineraux AntioXydants Study publication-title: Int J Vitam Nutr Res – volume: 76 start-page: 703 year: 2002 end-page: 716 ident: bib15 article-title: The European perspective on vitamin E: current knowledge and future research publication-title: Am J Clin Nutr – volume: 276 start-page: 1957 year: 1996 end-page: 1963 ident: bib6 article-title: Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group publication-title: JAMA – volume: 54 start-page: 315 year: 2003 end-page: 321 ident: bib20 article-title: Selenomethionine does not affect PSA secretion independent of its effect on LNCaP cell growth publication-title: Prostate – volume: 37 start-page: 96 year: 2000 ident: bib8 article-title: Tertiary prevention of prostate cancer by dietary intervention: results of a randomised, double blind, placebo controlled, cross-over study publication-title: Eur J Urol – volume: 3 start-page: 605 year: 2004 end-page: 611 ident: bib19 article-title: Methyl selenium metabolites decrease prostate-specific antigen expression by inducing protein degradation and suppressing androgen-stimulated transcription publication-title: Mol Cancer Ther – reference: NEVO Foundation. Dutch food composition table. The Hague: Netherlands Bureau for Nutrition Education; 2001. – volume: 18 start-page: 13 year: 1999 end-page: 25 ident: bib21 article-title: High doses of multiple antioxidant vitamins: essential ingredients in improving the efficacy of standard cancer therapy publication-title: J Am Coll Nutr – volume: 17 start-page: 115 year: 1992 end-page: 122 ident: bib11 article-title: Inhibition of 7,12-dimethylbenz[a]anthracene-induced lipid peroxidation and mammary tumor development in rats by vitamin E in conjunction with selenium publication-title: Nutr Cancer – volume: 361 start-page: 859 year: 2003 end-page: 864 ident: bib1 article-title: Prostate cancer epidemiology publication-title: Lancet – year: 1996 ident: bib2 article-title: Nutrition and cancer – volume: 90 start-page: 440 year: 1998 end-page: 446 ident: bib5 article-title: Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial publication-title: J Natl Cancer Inst – volume: 90 start-page: 1219 year: 1998 end-page: 1224 ident: bib18 article-title: Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer publication-title: J Natl Cancer Inst – volume: 76 start-page: 703 year: 2002 ident: 10.1016/j.eururo.2004.11.017_bib15 article-title: The European perspective on vitamin E: current knowledge and future research publication-title: Am J Clin Nutr doi: 10.1093/ajcn/76.4.703 – volume: 68 start-page: 3 issue: 1 year: 1998 ident: 10.1016/j.eururo.2004.11.017_bib12 article-title: Background and rationale behind the SU.VI.MAX Study, a prevention trial using nutritional doses of a combination of antioxidant vitamins and minerals to reduce cardiovascular diseases and cancers. SUpplementation en VItamines et Mineraux AntioXydants Study publication-title: Int J Vitam Nutr Res – volume: 93 start-page: 1139 year: 2004 ident: 10.1016/j.eururo.2004.11.017_bib4 article-title: Diet, anthropometric measures and prostate cancer risk: a review of prospective cohort and intervention studies publication-title: BJU Int doi: 10.1111/j.1464-410X.2004.04795.x – volume: 18 start-page: 13 year: 1999 ident: 10.1016/j.eururo.2004.11.017_bib21 article-title: High doses of multiple antioxidant vitamins: essential ingredients in improving the efficacy of standard cancer therapy publication-title: J Am Coll Nutr doi: 10.1080/07315724.1999.10718822 – volume: 234 start-page: 296 year: 1997 ident: 10.1016/j.eururo.2004.11.017_bib9 article-title: Activities of vitamin Q10 in animal models and a serious deficiency in patients with cancer publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.1997.6522 – volume: 66 start-page: 145 year: 1996 ident: 10.1016/j.eururo.2004.11.017_bib17 article-title: Prediction of male cancer mortality by plasma levels of interacting vitamins: 17-year follow-up of the prospective Basel study publication-title: Int J Cancer doi: 10.1002/(SICI)1097-0215(19960410)66:2<145::AID-IJC1>3.0.CO;2-2 – volume: 121 start-page: 385 year: 1997 ident: 10.1016/j.eururo.2004.11.017_bib16 article-title: Variation of free and total prostate-specific antigen levels: the effect on the percent free/total prostate-specific antigen publication-title: Arch Pathol Lab Med – volume: 18 start-page: 13 year: 1999 ident: 10.1016/j.eururo.2004.11.017_bib7 article-title: High doses of multiple antioxidant vitamins: essential ingredients in improving the efficacy of standard cancer therapy publication-title: J Am Coll Nutr doi: 10.1080/07315724.1999.10718822 – volume: 3 start-page: 605 year: 2004 ident: 10.1016/j.eururo.2004.11.017_bib19 article-title: Methyl selenium metabolites decrease prostate-specific antigen expression by inducing protein degradation and suppressing androgen-stimulated transcription publication-title: Mol Cancer Ther doi: 10.1158/1535-7163.605.3.5 – volume: 90 start-page: 1219 year: 1998 ident: 10.1016/j.eururo.2004.11.017_bib18 article-title: Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer publication-title: J Natl Cancer Inst doi: 10.1093/jnci/90.16.1219 – ident: 10.1016/j.eururo.2004.11.017_bib14 – volume: 90 start-page: 440 year: 1998 ident: 10.1016/j.eururo.2004.11.017_bib5 article-title: Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial publication-title: J Natl Cancer Inst doi: 10.1093/jnci/90.6.440 – volume: 361 start-page: 859 year: 2003 ident: 10.1016/j.eururo.2004.11.017_bib1 article-title: Prostate cancer epidemiology publication-title: Lancet doi: 10.1016/S0140-6736(03)12713-4 – volume: 54 start-page: 315 year: 2003 ident: 10.1016/j.eururo.2004.11.017_bib20 article-title: Selenomethionine does not affect PSA secretion independent of its effect on LNCaP cell growth publication-title: Prostate doi: 10.1002/pros.10184 – start-page: 287 year: 2003 ident: 10.1016/j.eururo.2004.11.017_bib3 article-title: Chemoprevention of prostate cancer – year: 1998 ident: 10.1016/j.eururo.2004.11.017_bib10 article-title: Regression of prostate cancer and plasma specific antigens (PSA) in patients on treatment with CoQ10 – volume: 37 start-page: 96 year: 2000 ident: 10.1016/j.eururo.2004.11.017_bib8 article-title: Tertiary prevention of prostate cancer by dietary intervention: results of a randomised, double blind, placebo controlled, cross-over study publication-title: Eur J Urol – volume: 17 start-page: 115 year: 1992 ident: 10.1016/j.eururo.2004.11.017_bib11 article-title: Inhibition of 7,12-dimethylbenz[a]anthracene-induced lipid peroxidation and mammary tumor development in rats by vitamin E in conjunction with selenium publication-title: Nutr Cancer doi: 10.1080/01635589209514179 – volume: 9 start-page: 365 year: 1999 ident: 10.1016/j.eururo.2004.11.017_bib22 article-title: CoQ10: could it have a role in cancer management? publication-title: Biofactors doi: 10.1002/biof.5520090237 – year: 1996 ident: 10.1016/j.eururo.2004.11.017_bib2 – volume: 276 start-page: 1957 year: 1996 ident: 10.1016/j.eururo.2004.11.017_bib6 article-title: Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group publication-title: JAMA doi: 10.1001/jama.276.24.1957 – year: 1997 ident: 10.1016/j.eururo.2004.11.017_bib13
SSID	ssj0003593
Score	1.9604127
Snippet	To assess the effect of a nutritional supplement containing vitamin E, selenium, vitamin C and coenzyme Q10 on changes in serum levels of PSA in patients with...
SourceID	proquest pubmed crossref elsevier
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	433
SubjectTerms	Aged Aged, 80 and over Anti-oxidants Ascorbic Acid - therapeutic use Coenzyme Q10 Coenzymes Dietary Supplements Double-Blind Method Drug Therapy, Combination Hormones Humans Male Middle Aged Nutrition Prostate cancer Prostate-Specific Antigen - blood Prostatic Neoplasms - blood Prostatic Neoplasms - drug therapy PSA Selenium Selenium - therapeutic use Ubiquinone - analogs & derivatives Ubiquinone - therapeutic use Vitamin C Vitamin E Vitamin E - therapeutic use
Title	Effect of a Nutritional Supplement Containing Vitamin E, Selenium, Vitamin C and Coenzyme Q10 on Serum PSA in Patients with Hormonally Untreated Carcinoma of the Prostate: A Randomised Placebo-Controlled Study
URI	https://www.clinicalkey.com/#!/content/1-s2.0-S0302283804006256 https://dx.doi.org/10.1016/j.eururo.2004.11.017 https://www.ncbi.nlm.nih.gov/pubmed/15774238 https://www.proquest.com/docview/67524732
Volume	47
WOSCitedRecordID	wos000228121500002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1873-7560 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0003593 issn: 0302-2838 databaseCode: AIEXJ dateStart: 20020101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF41LUJcEG_Co8yBW2orttdZm1sUpZSWRoEWlJu1ttdSQmJXbVq1_Ev-EbMvOzSqWpC4ONHaa28yn-1vZ2e-IeS91y0oTcPCoWERONTvCicq8H7MREo58ts84JkqNsFGo2gyiccbrS2bC3MxZ2UZXV7GJ__V1NiGxpaps39h7vqk2IDf0ei4RbPj9k6GN3rEKu9xZLX2peaHrN-pnIEyzW-pK0N0vk-XfDEtOyoo8ki-g6a68rHdoYM7B5Uof14tROeL1-3oR4yMoD_qS3_JWGuzmkS5PWTB8oLzKyS0Ko5dOpFlyaKyWnAbkzCW2SZSNUNlxn_Fa1SIODxyLP36aeUMdAz9XBFiK4F7fQkBP1dXBfZwlDO9unLgHrr77md312188bJis16OGbuDpl3MudCe-AN3jJ0aV9Qs-7EwE42RO3Q_un_4SMKV0BrluFtL3tEJYyozXYvL2JeBlv80oKcrT3aq9ToMSaBaY2rt_aNdITMp2on_gHI_uFIkVuenXlP2PpIjkAOQD1Kch_ZaZMtnYRxtkq3-p-Fkv6YUgVGPtiO2OaAqUHH9WjdxrJvmUIpLHT8iD80kCPoavI_JhiifkPuHJszjKfmlMQxVARxWMAwNhqHBMBiownAHLIJ36sYBILbA4hcQv1CVoPALiF_AQyx-QeIXGvxCjV-o8SvHhPgFi98P0IcGvbCOXlDofUa-7Q6PB3uOqT3iZEjrlk5OhaA4_eGRF_Io4mEQZyyLRRYgZRc8KKjHe6zIgyDkfq_wWcbisIhxd0p7XpQHz8lmWZXiJQGeZsjqCxHkrKB5GqZ-FIvIxxcnnsLLaZsE1lpJZoT5ZX2YeWIjMGeJtrGsGUtxzp6gjdvEqXudaGGaW44PLRASm3SNNCFB5N7Sj9X9DCnXZPsOPd9ZvCVoA7kQyUtRnZ8lPRb6lAV-m7zQMGx-Qchk6Ej06h9H-5o8aO7_N2RzeXou3pJ72cVyena6TVpsEm2bm-s3DGweyw
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effect+of+a+Nutritional+Supplement+Containing+Vitamin+E%2C+Selenium%2C+Vitamin+C+and+Coenzyme+Q10+on+Serum+PSA+in+Patients+with+Hormonally+Untreated+Carcinoma+of+the+Prostate%3A+A+Randomised+Placebo-Controlled+Study&rft.jtitle=European+urology&rft.au=Hoenjet%2C+K.M.J.L.F.&rft.au=Dagnelie%2C+P.C.&rft.au=Delaere%2C+K.P.J.&rft.au=Wijckmans%2C+N.E.G.&rft.date=2005-04-01&rft.pub=Elsevier+B.V&rft.issn=0302-2838&rft.volume=47&rft.issue=4&rft.spage=433&rft.epage=440&rft_id=info:doi/10.1016%2Fj.eururo.2004.11.017&rft.externalDocID=S0302283804006256
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0302-2838&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0302-2838&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0302-2838&client=summon