Effect of a Nutritional Supplement Containing Vitamin E, Selenium, Vitamin C and Coenzyme Q10 on Serum PSA in Patients with Hormonally Untreated Carcinoma of the Prostate: A Randomised Placebo-Controlled Study

To assess the effect of a nutritional supplement containing vitamin E, selenium, vitamin C and coenzyme Q10 on changes in serum levels of PSA in patients with hormonally untreated carcinoma of the prostate and rising serum PSA levels. Eighty patients were randomised to receive a daily supplement wit...

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Vydáno v:European urology Ročník 47; číslo 4; s. 433 - 440
Hlavní autoři: Hoenjet, K.M.J.L.F., Dagnelie, P.C., Delaere, K.P.J., Wijckmans, N.E.G., Zambon, J.V., Oosterhof, G.O.N.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland Elsevier B.V 01.04.2005
Témata:
Aged
Aged, 80 and over
Anti-oxidants
Ascorbic Acid - therapeutic use
Coenzyme Q10
Coenzymes
Dietary Supplements
Double-Blind Method
Drug Therapy, Combination
Hormones
Humans
Male
Middle Aged
Nutrition
Prostate cancer
Prostate-Specific Antigen - blood
Prostatic Neoplasms - blood
Prostatic Neoplasms - drug therapy
PSA
Selenium
Selenium - therapeutic use
Ubiquinone - analogs & derivatives
Ubiquinone - therapeutic use
Vitamin C
Vitamin E
Vitamin E - therapeutic use
Anti-oxidants
Nutrition
Vitamin E
Coenzyme Q10
Vitamin C
Selenium
Prostate cancer
PSA
ISSN:0302-2838, 1873-7560
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Shrnutí:To assess the effect of a nutritional supplement containing vitamin E, selenium, vitamin C and coenzyme Q10 on changes in serum levels of PSA in patients with hormonally untreated carcinoma of the prostate and rising serum PSA levels. Eighty patients were randomised to receive a daily supplement with either vitamin E, selenium, vitamin C, coenzyme Q10 (intervention group) or placebo over 21 weeks. Serum levels of PSA were assessed at baseline (−2, −1, 0 weeks) and after 6, 13, 19, 20 and 21 weeks. Mean changes in log serum level of PSA, testosterone, dihydrotestosterone, luteinizing hormone and sex hormone binding globulin over 21 weeks between the verum and the placebo group were compared by analysis of covariance. Seventy patients completed the study (36 verum; 34 placebo). Compliance was >90% in all patients. In the intervention group, plasma levels of vitamin E, selenium and coenzyme Q10 increased significantly over the 21 weeks study period. No significant differences in serum levels of PSA, testosterone, dihydrotestosterone, luteinizing hormone or sex hormone binding globulin ( p > 0.2) were observed between the intervention and control group. Our results indicate that supplementation of a combination of vitamin E, selenium, vitamin C and coenzyme-Q10 does not affect serum level of PSA or hormone levels in patients with hormonally untreated carcinoma of the prostate.
Bibliografie:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0302-2838
1873-7560
DOI:10.1016/j.eururo.2004.11.017