Investigation of inhalation and exhalation flow pattern in a realistic human upper airway model by PIV experiments and CFD simulations

In this study, flow field characteristics in the trachea region in a realistic human upper airway model were firstly measured by particle image velocimetry (PIV) in the air under three constant inhalation and exhalation conditions: 36 L/min, 64 L/min and 90 L/min, representing flow rates of 18 L/min...

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Vydáno v:	Biomechanics and modeling in mechanobiology Ročník 19; číslo 5; s. 1679 - 1695
Hlavní autoři:	Xu, Xiaoyu, Wu, Jialin, Weng, Wenguo, Fu, Ming
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2020
Témata:	Biological and Medical Physics Biomedical Engineering and Bioengineering Biophysics Engineering Original Paper Theoretical and Applied Mechanics Human upper airway model CFD PIV Flow field distribution
ISSN:	1617-7959, 1617-7940, 1617-7940
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Abstract	In this study, flow field characteristics in the trachea region in a realistic human upper airway model were firstly measured by particle image velocimetry (PIV) in the air under three constant inhalation and exhalation conditions: 36 L/min, 64 L/min and 90 L/min, representing flow rates of 18 L/min, 32 L/min and 45 L/min in real human airway (the model was twice the size of a human airway). Computational fluid dynamics (CFD) analyses were performed on four turbulence models, with boundary conditions corresponding to the PIV experiments. The effects of flow rates and breathing modes on the airflow patterns were investigated. The CFD prediction results were compared with the PIV measurements and showed relatively good agreement in all cases. During inhalation, the higher the flow rates, the less significant the “glottal jet” phenomenon, and the smaller the area of the separation zone. The air in the nasal inhalation condition accelerated more dramatically after glottis. The SST-Transition model was the best choice for predicting inhalation velocity profiles. For exhalation condition, the maximum velocity was much smaller than that during inhalation due to the more uniform flow field. The exhalation flow rates and breathing modes had little effect on the flow characteristics in the trachea region. The RNG k − ε model and SST k − ω model were recommended to simulate the flow field in the respiratory tract during exhalation.
AbstractList	In this study, flow field characteristics in the trachea region in a realistic human upper airway model were firstly measured by particle image velocimetry (PIV) in the air under three constant inhalation and exhalation conditions: 36 L/min, 64 L/min and 90 L/min, representing flow rates of 18 L/min, 32 L/min and 45 L/min in real human airway (the model was twice the size of a human airway). Computational fluid dynamics (CFD) analyses were performed on four turbulence models, with boundary conditions corresponding to the PIV experiments. The effects of flow rates and breathing modes on the airflow patterns were investigated. The CFD prediction results were compared with the PIV measurements and showed relatively good agreement in all cases. During inhalation, the higher the flow rates, the less significant the “glottal jet” phenomenon, and the smaller the area of the separation zone. The air in the nasal inhalation condition accelerated more dramatically after glottis. The SST-Transition model was the best choice for predicting inhalation velocity profiles. For exhalation condition, the maximum velocity was much smaller than that during inhalation due to the more uniform flow field. The exhalation flow rates and breathing modes had little effect on the flow characteristics in the trachea region. The RNG k − ε model and SST k − ω model were recommended to simulate the flow field in the respiratory tract during exhalation. In this study, flow field characteristics in the trachea region in a realistic human upper airway model were firstly measured by particle image velocimetry (PIV) in the air under three constant inhalation and exhalation conditions: 36 L/min, 64 L/min and 90 L/min, representing flow rates of 18 L/min, 32 L/min and 45 L/min in real human airway (the model was twice the size of a human airway). Computational fluid dynamics (CFD) analyses were performed on four turbulence models, with boundary conditions corresponding to the PIV experiments. The effects of flow rates and breathing modes on the airflow patterns were investigated. The CFD prediction results were compared with the PIV measurements and showed relatively good agreement in all cases. During inhalation, the higher the flow rates, the less significant the "glottal jet" phenomenon, and the smaller the area of the separation zone. The air in the nasal inhalation condition accelerated more dramatically after glottis. The SST-Transition model was the best choice for predicting inhalation velocity profiles. For exhalation condition, the maximum velocity was much smaller than that during inhalation due to the more uniform flow field. The exhalation flow rates and breathing modes had little effect on the flow characteristics in the trachea region. The RNG k - ε model and SST k - ω model were recommended to simulate the flow field in the respiratory tract during exhalation.In this study, flow field characteristics in the trachea region in a realistic human upper airway model were firstly measured by particle image velocimetry (PIV) in the air under three constant inhalation and exhalation conditions: 36 L/min, 64 L/min and 90 L/min, representing flow rates of 18 L/min, 32 L/min and 45 L/min in real human airway (the model was twice the size of a human airway). Computational fluid dynamics (CFD) analyses were performed on four turbulence models, with boundary conditions corresponding to the PIV experiments. The effects of flow rates and breathing modes on the airflow patterns were investigated. The CFD prediction results were compared with the PIV measurements and showed relatively good agreement in all cases. During inhalation, the higher the flow rates, the less significant the "glottal jet" phenomenon, and the smaller the area of the separation zone. The air in the nasal inhalation condition accelerated more dramatically after glottis. The SST-Transition model was the best choice for predicting inhalation velocity profiles. For exhalation condition, the maximum velocity was much smaller than that during inhalation due to the more uniform flow field. The exhalation flow rates and breathing modes had little effect on the flow characteristics in the trachea region. The RNG k - ε model and SST k - ω model were recommended to simulate the flow field in the respiratory tract during exhalation. In this study, flow field characteristics in the trachea region in a realistic human upper airway model were firstly measured by particle image velocimetry (PIV) in the air under three constant inhalation and exhalation conditions: 36 L/min, 64 L/min and 90 L/min, representing flow rates of 18 L/min, 32 L/min and 45 L/min in real human airway (the model was twice the size of a human airway). Computational fluid dynamics (CFD) analyses were performed on four turbulence models, with boundary conditions corresponding to the PIV experiments. The effects of flow rates and breathing modes on the airflow patterns were investigated. The CFD prediction results were compared with the PIV measurements and showed relatively good agreement in all cases. During inhalation, the higher the flow rates, the less significant the "glottal jet" phenomenon, and the smaller the area of the separation zone. The air in the nasal inhalation condition accelerated more dramatically after glottis. The SST-Transition model was the best choice for predicting inhalation velocity profiles. For exhalation condition, the maximum velocity was much smaller than that during inhalation due to the more uniform flow field. The exhalation flow rates and breathing modes had little effect on the flow characteristics in the trachea region. The RNG k - ε model and SST k - ω model were recommended to simulate the flow field in the respiratory tract during exhalation.
Author	Fu, Ming Weng, Wenguo Wu, Jialin Xu, Xiaoyu
Author_xml	– sequence: 1 givenname: Xiaoyu surname: Xu fullname: Xu, Xiaoyu organization: Institute of Public Safety Research, Department of Engineering Physics, Tsinghua University, Beijing Key Laboratory of City Integrated Emergency Response Science, Tsinghua University – sequence: 2 givenname: Jialin surname: Wu fullname: Wu, Jialin organization: Institute of Public Safety Research, Department of Engineering Physics, Tsinghua University, Beijing Key Laboratory of City Integrated Emergency Response Science, Tsinghua University – sequence: 3 givenname: Wenguo surname: Weng fullname: Weng, Wenguo email: wgweng@tsinghua.edu.cn organization: Institute of Public Safety Research, Department of Engineering Physics, Tsinghua University, Beijing Key Laboratory of City Integrated Emergency Response Science, Tsinghua University – sequence: 4 givenname: Ming surname: Fu fullname: Fu, Ming organization: Hefei Institute for Public Safety Research, Tsinghua University
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Snippet	In this study, flow field characteristics in the trachea region in a realistic human upper airway model were firstly measured by particle image velocimetry...
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Title	Investigation of inhalation and exhalation flow pattern in a realistic human upper airway model by PIV experiments and CFD simulations
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