Vitreous Humor: Composition, Characteristics and Implication on Intravitreal Drug Delivery

Purpose: Intravitreal administration of drug molecules is one of the most common routes for treating posterior segment eye diseases. However, the properties of vitreous humour changes with the time. A number of ocular complications such as liquefaction of the vitreous humour, solidification of the v...

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Veröffentlicht in:Current eye research Jg. 48; H. 2; S. 208 - 218
Hauptverfasser: Mishra, Deepakkumar, Gade, Shilpkala, Glover, Katie, Sheshala, Ravi, Singh, Thakur Raghu Raj
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Taylor & Francis 01.02.2023
Schlagworte:
biomechanics
Drug Delivery Systems - methods
Eye Diseases
Humans
Intravitreal Injections
intravitreal therapy
Ocular drug delivery systems
Pharmaceutical Preparations
posterior segment drug delivery
Vitreous Body
Ocular drug delivery systems
intravitreal therapy
posterior segment drug delivery
biomechanics
ISSN:0271-3683, 1460-2202, 1460-2202
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Abstract Purpose: Intravitreal administration of drug molecules is one of the most common routes for treating posterior segment eye diseases. However, the properties of vitreous humour changes with the time. A number of ocular complications such as liquefaction of the vitreous humour, solidification of the vitreous humour in the central vitreous cavity and detachment of the limiting membrane due to the shrinking of vitreous humour are some of the factors that can drastically affect the efficacy of therapeutics delivered via intravitreal route. Although significant research has been conducted for studying the properties of vitreous humour and its changes during the ageing process, there have been limited work to understand the effect of these changes on therapeutic efficacy of intravitreal drug delivery systems. Therefore, in this review we discussed both the coomposition and characteristics of the vitreous humour, and their subsequent influence on intravitreal drug delivery. Methods: Articles were searched on Scopus, PubMed and Web of Science up to March 2022. Results: In this review, we discussed the biological composition and biomechanical properties of vitreous humour, methods to study the properties of vitreous humour and the changes in these properties and their relevance in ocular drug delivery field, with the aim to provide a useful insight into these aspects which can aid the process of development of novel intravitreal drug delivery systems. Conclusions: The composition and characteristics of the vitreous humour, and how these change during natural aging processes, directly influence intravitreal drug delivery. This review therefore highlights the importance of understanding the properties of the vitreous and identifies the need to achieve greater understanding of how changing properties of the vitreous affect the therapeutic efficacy of drugs administered for the treatment of posterior eye diseases.
AbstractList Intravitreal administration of drug molecules is one of the most common routes for treating posterior segment eye diseases. However, the properties of vitreous humour changes with the time. A number of ocular complications such as liquefaction of the vitreous humour, solidification of the vitreous humour in the central vitreous cavity and detachment of the limiting membrane due to the shrinking of vitreous humour are some of the factors that can drastically affect the efficacy of therapeutics delivered via intravitreal route. Although significant research has been conducted for studying the properties of vitreous humour and its changes during the ageing process, there have been limited work to understand the effect of these changes on therapeutic efficacy of intravitreal drug delivery systems. Therefore, in this review we discussed both the coomposition and characteristics of the vitreous humour, and their subsequent influence on intravitreal drug delivery. Articles were searched on Scopus, PubMed and Web of Science up to March 2022. In this review, we discussed the biological composition and biomechanical properties of vitreous humour, methods to study the properties of vitreous humour and the changes in these properties and their relevance in ocular drug delivery field, with the aim to provide a useful insight into these aspects which can aid the process of development of novel intravitreal drug delivery systems. The composition and characteristics of the vitreous humour, and how these change during natural aging processes, directly influence intravitreal drug delivery. This review therefore highlights the importance of understanding the properties of the vitreous and identifies the need to achieve greater understanding of how changing properties of the vitreous affect the therapeutic efficacy of drugs administered for the treatment of posterior eye diseases.
Purpose: Intravitreal administration of drug molecules is one of the most common routes for treating posterior segment eye diseases. However, the properties of vitreous humour changes with the time. A number of ocular complications such as liquefaction of the vitreous humour, solidification of the vitreous humour in the central vitreous cavity and detachment of the limiting membrane due to the shrinking of vitreous humour are some of the factors that can drastically affect the efficacy of therapeutics delivered via intravitreal route. Although significant research has been conducted for studying the properties of vitreous humour and its changes during the ageing process, there have been limited work to understand the effect of these changes on therapeutic efficacy of intravitreal drug delivery systems. Therefore, in this review we discussed both the coomposition and characteristics of the vitreous humour, and their subsequent influence on intravitreal drug delivery.Methods: Articles were searched on Scopus, PubMed and Web of Science up to March 2022.Results: In this review, we discussed the biological composition and biomechanical properties of vitreous humour, methods to study the properties of vitreous humour and the changes in these properties and their relevance in ocular drug delivery field, with the aim to provide a useful insight into these aspects which can aid the process of development of novel intravitreal drug delivery systems.Conclusions: The composition and characteristics of the vitreous humour, and how these change during natural aging processes, directly influence intravitreal drug delivery. This review therefore highlights the importance of understanding the properties of the vitreous and identifies the need to achieve greater understanding of how changing properties of the vitreous affect the therapeutic efficacy of drugs administered for the treatment of posterior eye diseases.Purpose: Intravitreal administration of drug molecules is one of the most common routes for treating posterior segment eye diseases. However, the properties of vitreous humour changes with the time. A number of ocular complications such as liquefaction of the vitreous humour, solidification of the vitreous humour in the central vitreous cavity and detachment of the limiting membrane due to the shrinking of vitreous humour are some of the factors that can drastically affect the efficacy of therapeutics delivered via intravitreal route. Although significant research has been conducted for studying the properties of vitreous humour and its changes during the ageing process, there have been limited work to understand the effect of these changes on therapeutic efficacy of intravitreal drug delivery systems. Therefore, in this review we discussed both the coomposition and characteristics of the vitreous humour, and their subsequent influence on intravitreal drug delivery.Methods: Articles were searched on Scopus, PubMed and Web of Science up to March 2022.Results: In this review, we discussed the biological composition and biomechanical properties of vitreous humour, methods to study the properties of vitreous humour and the changes in these properties and their relevance in ocular drug delivery field, with the aim to provide a useful insight into these aspects which can aid the process of development of novel intravitreal drug delivery systems.Conclusions: The composition and characteristics of the vitreous humour, and how these change during natural aging processes, directly influence intravitreal drug delivery. This review therefore highlights the importance of understanding the properties of the vitreous and identifies the need to achieve greater understanding of how changing properties of the vitreous affect the therapeutic efficacy of drugs administered for the treatment of posterior eye diseases.
Purpose: Intravitreal administration of drug molecules is one of the most common routes for treating posterior segment eye diseases. However, the properties of vitreous humour changes with the time. A number of ocular complications such as liquefaction of the vitreous humour, solidification of the vitreous humour in the central vitreous cavity and detachment of the limiting membrane due to the shrinking of vitreous humour are some of the factors that can drastically affect the efficacy of therapeutics delivered via intravitreal route. Although significant research has been conducted for studying the properties of vitreous humour and its changes during the ageing process, there have been limited work to understand the effect of these changes on therapeutic efficacy of intravitreal drug delivery systems. Therefore, in this review we discussed both the coomposition and characteristics of the vitreous humour, and their subsequent influence on intravitreal drug delivery. Methods: Articles were searched on Scopus, PubMed and Web of Science up to March 2022. Results: In this review, we discussed the biological composition and biomechanical properties of vitreous humour, methods to study the properties of vitreous humour and the changes in these properties and their relevance in ocular drug delivery field, with the aim to provide a useful insight into these aspects which can aid the process of development of novel intravitreal drug delivery systems. Conclusions: The composition and characteristics of the vitreous humour, and how these change during natural aging processes, directly influence intravitreal drug delivery. This review therefore highlights the importance of understanding the properties of the vitreous and identifies the need to achieve greater understanding of how changing properties of the vitreous affect the therapeutic efficacy of drugs administered for the treatment of posterior eye diseases.
Author Glover, Katie
Gade, Shilpkala
Mishra, Deepakkumar
Sheshala, Ravi
Singh, Thakur Raghu Raj
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  fullname: Gade, Shilpkala
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  surname: Glover
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  organization: School of Pharmacy, Medical Biology Centre, Queen's University Belfast
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  surname: Sheshala
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  organization: Faculty of Pharmacy, Research Group of Affinity, Safety and Efficacy Studies (OASES), Universiti Teknologi MARA Selangor
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  givenname: Thakur Raghu Raj
  orcidid: 0000-0001-7582-2082
  surname: Singh
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/36036478$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/j.jmbbm.2014.09.004
10.1016/j.preteyeres.2016.12.001
10.1007/s00417-016-3431-x
10.1042/BJ20111379
10.1167/IOVS.02-0588
10.1208/s12249-021-01949-4
10.3389/FBIOE.2018.00199/BIBTEX
10.1167/iovs.14-14126
10.1007/PL00011360
10.1136/bjo.84.11.1312
10.1167/iovs.11-7790
10.1007/s00397-017-0997-0
10.3233/BIR-1994-31404
10.1016/j.bpj.2015.10.002
10.1001/jamanetworkopen.2019.2162
10.1016/j.ophtha.2021.09.016
10.1167/iovs.11-8514
10.1007/s10719-017-9808-1
10.1177/112067210901900319
10.1002/PAMM.201900462
10.1038/eye.2008.21
10.4155/tde-2019-0024
10.1021/acs.jproteome.5b00900
10.1016/J.PRETEYERES.2020.100845
10.1016/j.clae.2019.04.018
10.1073/pnas.1817564116
10.1001/jamaophthalmol.2015.4110
10.1159/000265211
10.1038/eye.2017.149
10.1098/rstb.2010.0228
10.1007/s10439-005-8974-7
10.1016/j.ijpharm.2018.07.070
10.1167/iovs.14-15414
10.1042/bj2990497
10.1038/SJ.EYE.6700201
10.1167/iovs.14-14366
10.3390/PHARMACEUTICS11080365
10.3174/AJNR.A2543
10.1038/301618a0
10.1016/j.jprot.2013.01.004
10.1186/s41077-021-00167-z
10.3389/fimmu.2020.567274
10.1136/bmj.326.7397.1023
10.1016/j.carbpol.2021.117697
10.4103/ijo.IJO_373_18
10.1136/BJO.33.4.242
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Issue 2
Keywords Ocular drug delivery systems
intravitreal therapy
posterior segment drug delivery
biomechanics
Language English
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References Hannover A. (CIT0003) 1842
CIT0030
CIT0032
CIT0034
CIT0033
CIT0035
CIT0038
CIT0037
CIT0039
CIT0041
CIT0040
CIT0043
CIT0042
CIT0045
CIT0044
CIT0047
CIT0002
CIT0046
CIT0005
CIT0049
CIT0004
CIT0048
CIT0007
CIT0006
CIT0009
CIT0008
CIT0050
CIT0052
WHO. (CIT0001) 2019
CIT0051
CIT0010
CIT0053
CIT0012
CIT0056
CIT0011
CIT0055
Fanea L (CIT0054) 2012; 18
Sotoodehnejadnematalahi F (CIT0036) 2013; 51
CIT0014
CIT0058
CIT0013
CIT0057
CIT0016
CIT0015
CIT0018
CIT0017
Lindahl U (CIT0031)
CIT0019
CIT0021
CIT0020
CIT0023
CIT0022
CIT0025
CIT0024
CIT0027
CIT0026
CIT0029
CIT0028
References_xml – ident: CIT0015
– ident: CIT0044
  doi: 10.1016/j.jmbbm.2014.09.004
– ident: CIT0033
  doi: 10.1016/j.preteyeres.2016.12.001
– ident: CIT0011
– ident: CIT0010
  doi: 10.1007/s00417-016-3431-x
– ident: CIT0026
  doi: 10.1042/BJ20111379
– ident: CIT0048
  doi: 10.1167/IOVS.02-0588
– ident: CIT0008
  doi: 10.1208/s12249-021-01949-4
– ident: CIT0009
– ident: CIT0021
  doi: 10.3389/FBIOE.2018.00199/BIBTEX
– ident: CIT0037
  doi: 10.1167/iovs.14-14126
– ident: CIT0055
  doi: 10.1007/PL00011360
– ident: CIT0029
  doi: 10.1136/bjo.84.11.1312
– ident: CIT0050
  doi: 10.1167/iovs.11-7790
– ident: CIT0024
  doi: 10.1007/s00397-017-0997-0
– volume-title: Essentials of glycobiology, 2015
  ident: CIT0031
– ident: CIT0046
  doi: 10.3233/BIR-1994-31404
– ident: CIT0041
  doi: 10.1016/j.bpj.2015.10.002
– ident: CIT0051
  doi: 10.1001/jamanetworkopen.2019.2162
– ident: CIT0016
  doi: 10.1016/j.ophtha.2021.09.016
– ident: CIT0030
  doi: 10.1167/iovs.11-8514
– ident: CIT0020
  doi: 10.1007/s10719-017-9808-1
– ident: CIT0012
– volume-title: World report on vision
  year: 2019
  ident: CIT0001
– ident: CIT0053
  doi: 10.1177/112067210901900319
– ident: CIT0043
  doi: 10.1002/PAMM.201900462
– ident: CIT0019
  doi: 10.1038/eye.2008.21
– ident: CIT0014
  doi: 10.4155/tde-2019-0024
– ident: CIT0035
  doi: 10.1021/acs.jproteome.5b00900
– ident: CIT0042
  doi: 10.1016/J.PRETEYERES.2020.100845
– ident: CIT0023
  doi: 10.1016/j.clae.2019.04.018
– ident: CIT0057
  doi: 10.1073/pnas.1817564116
– ident: CIT0006
  doi: 10.1001/jamaophthalmol.2015.4110
– volume: 18
  start-page: 2538
  year: 2012
  ident: CIT0054
  publication-title: Mol Vis
– ident: CIT0047
  doi: 10.1159/000265211
– ident: CIT0005
  doi: 10.1038/eye.2017.149
– ident: CIT0039
  doi: 10.1098/rstb.2010.0228
– ident: CIT0032
  doi: 10.1007/s10439-005-8974-7
– ident: CIT0027
  doi: 10.1016/j.ijpharm.2018.07.070
– ident: CIT0052
  doi: 10.1167/iovs.14-15414
– ident: CIT0025
  doi: 10.1042/bj2990497
– ident: CIT0018
  doi: 10.1038/SJ.EYE.6700201
– volume: 51
  start-page: 740
  issue: 11
  year: 2013
  ident: CIT0036
  publication-title: Acta Med Iran
– ident: CIT0038
  doi: 10.1167/iovs.14-14366
– ident: CIT0056
– ident: CIT0017
  doi: 10.3390/PHARMACEUTICS11080365
– volume-title: Mikroskopiske undersögelser af nervesystemet
  year: 1842
  ident: CIT0003
– ident: CIT0040
  doi: 10.3174/AJNR.A2543
– ident: CIT0022
  doi: 10.1038/301618a0
– ident: CIT0045
– ident: CIT0004
  doi: 10.1016/j.jprot.2013.01.004
– ident: CIT0013
  doi: 10.1186/s41077-021-00167-z
– ident: CIT0028
  doi: 10.3389/fimmu.2020.567274
– ident: CIT0002
  doi: 10.1136/bmj.326.7397.1023
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  doi: 10.1016/j.carbpol.2021.117697
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  doi: 10.4103/ijo.IJO_373_18
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  doi: 10.1136/BJO.33.4.242
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Snippet Purpose: Intravitreal administration of drug molecules is one of the most common routes for treating posterior segment eye diseases. However, the properties of...
Intravitreal administration of drug molecules is one of the most common routes for treating posterior segment eye diseases. However, the properties of vitreous...
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SubjectTerms biomechanics
Drug Delivery Systems - methods
Eye Diseases
Humans
Intravitreal Injections
intravitreal therapy
Ocular drug delivery systems
Pharmaceutical Preparations
posterior segment drug delivery
Vitreous Body
Title Vitreous Humor: Composition, Characteristics and Implication on Intravitreal Drug Delivery
URI https://www.tandfonline.com/doi/abs/10.1080/02713683.2022.2119254
https://www.ncbi.nlm.nih.gov/pubmed/36036478
https://www.proquest.com/docview/2707874586
Volume 48
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