ADARp150 counteracts whole genome duplication
Impaired control of the G1/S checkpoint allows initiation of DNA replication under non-permissive conditions. Unscheduled S-phase entry is associated with DNA replication stress, demanding for other checkpoints or cellular pathways to maintain proliferation. Here, we uncovered a requirement for ADAR...
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| Published in: | Nucleic acids research Vol. 52; no. 17; pp. 10370 - 10384 |
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| Main Authors: | , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Oxford University Press
23.09.2024
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| ISSN: | 0305-1048, 1362-4962, 1362-4962 |
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| Abstract | Impaired control of the G1/S checkpoint allows initiation of DNA replication under non-permissive conditions. Unscheduled S-phase entry is associated with DNA replication stress, demanding for other checkpoints or cellular pathways to maintain proliferation. Here, we uncovered a requirement for ADARp150 to sustain proliferation of G1/S-checkpoint-defective cells under growth-restricting conditions. Besides its well-established mRNA editing function in inversely oriented short interspersed nuclear elements (SINEs), we found ADARp150 to exert a critical function in mitosis. ADARp150 depletion resulted in tetraploidization, impeding cell proliferation in mitogen-deprived conditions. Mechanistically we show that ADAR1 depletion induced aberrant expression of Cyclin B3, which was causative for mitotic failure and whole-genome duplication. Finally, we find that also in vivo ADAR1-depletion-provoked tetraploidization hampers tumor outgrowth.
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| AbstractList | Impaired control of the G1/S checkpoint allows initiation of DNA replication under non-permissive conditions. Unscheduled S-phase entry is associated with DNA replication stress, demanding for other checkpoints or cellular pathways to maintain proliferation. Here, we uncovered a requirement for ADARp150 to sustain proliferation of G1/S-checkpoint-defective cells under growth-restricting conditions. Besides its well-established mRNA editing function in inversely oriented short interspersed nuclear elements (SINEs), we found ADARp150 to exert a critical function in mitosis. ADARp150 depletion resulted in tetraploidization, impeding cell proliferation in mitogen-deprived conditions. Mechanistically we show that ADAR1 depletion induced aberrant expression of Cyclin B3, which was causative for mitotic failure and whole-genome duplication. Finally, we find that also in vivo ADAR1-depletion-provoked tetraploidization hampers tumor outgrowth.Impaired control of the G1/S checkpoint allows initiation of DNA replication under non-permissive conditions. Unscheduled S-phase entry is associated with DNA replication stress, demanding for other checkpoints or cellular pathways to maintain proliferation. Here, we uncovered a requirement for ADARp150 to sustain proliferation of G1/S-checkpoint-defective cells under growth-restricting conditions. Besides its well-established mRNA editing function in inversely oriented short interspersed nuclear elements (SINEs), we found ADARp150 to exert a critical function in mitosis. ADARp150 depletion resulted in tetraploidization, impeding cell proliferation in mitogen-deprived conditions. Mechanistically we show that ADAR1 depletion induced aberrant expression of Cyclin B3, which was causative for mitotic failure and whole-genome duplication. Finally, we find that also in vivo ADAR1-depletion-provoked tetraploidization hampers tumor outgrowth. Impaired control of the G1/S checkpoint allows initiation of DNA replication under non-permissive conditions. Unscheduled S-phase entry is associated with DNA replication stress, demanding for other checkpoints or cellular pathways to maintain proliferation. Here, we uncovered a requirement for ADARp150 to sustain proliferation of G1/S-checkpoint-defective cells under growth-restricting conditions. Besides its well-established mRNA editing function in inversely oriented short interspersed nuclear elements (SINEs), we found ADARp150 to exert a critical function in mitosis. ADARp150 depletion resulted in tetraploidization, impeding cell proliferation in mitogen-deprived conditions. Mechanistically we show that ADAR1 depletion induced aberrant expression of Cyclin B3, which was causative for mitotic failure and whole-genome duplication. Finally, we find that also in vivo ADAR1-depletion-provoked tetraploidization hampers tumor outgrowth. Impaired control of the G1/S checkpoint allows initiation of DNA replication under non-permissive conditions. Unscheduled S-phase entry is associated with DNA replication stress, demanding for other checkpoints or cellular pathways to maintain proliferation. Here, we uncovered a requirement for ADARp150 to sustain proliferation of G1/S-checkpoint-defective cells under growth-restricting conditions. Besides its well-established mRNA editing function in inversely oriented short interspersed nuclear elements (SINEs), we found ADARp150 to exert a critical function in mitosis. ADARp150 depletion resulted in tetraploidization, impeding cell proliferation in mitogen-deprived conditions. Mechanistically we show that ADAR1 depletion induced aberrant expression of Cyclin B3, which was causative for mitotic failure and whole-genome duplication. Finally, we find that also in vivo ADAR1-depletion-provoked tetraploidization hampers tumor outgrowth. Graphical Abstract Graphical Abstract Impaired control of the G1/S checkpoint allows initiation of DNA replication under non-permissive conditions. Unscheduled S-phase entry is associated with DNA replication stress, demanding for other checkpoints or cellular pathways to maintain proliferation. Here, we uncovered a requirement for ADARp150 to sustain proliferation of G1/S-checkpoint-defective cells under growth-restricting conditions. Besides its well-established mRNA editing function in inversely oriented short interspersed nuclear elements (SINEs), we found ADARp150 to exert a critical function in mitosis. ADARp150 depletion resulted in tetraploidization, impeding cell proliferation in mitogen-deprived conditions. Mechanistically we show that ADAR1 depletion induced aberrant expression of Cyclin B3, which was causative for mitotic failure and whole-genome duplication. Finally, we find that also in vivo ADAR1-depletion-provoked tetraploidization hampers tumor outgrowth. Graphical Abstract |
| Author | van Gemert, Frank Proost, Natalie Jacobs, Heinz Drakaki, Alexandra Lozano, Isabel Morales de Groot, Daniël te Riele, Hein van de Ven, Marieke Beijersbergen, Roderick L Uiterkamp, Maud Schoot Lieftink, Cor |
| Author_xml | – sequence: 1 givenname: Frank surname: van Gemert fullname: van Gemert, Frank – sequence: 2 givenname: Alexandra surname: Drakaki fullname: Drakaki, Alexandra – sequence: 3 givenname: Isabel Morales surname: Lozano fullname: Lozano, Isabel Morales – sequence: 4 givenname: Daniël surname: de Groot fullname: de Groot, Daniël – sequence: 5 givenname: Maud Schoot surname: Uiterkamp fullname: Uiterkamp, Maud Schoot – sequence: 6 givenname: Natalie surname: Proost fullname: Proost, Natalie – sequence: 7 givenname: Cor surname: Lieftink fullname: Lieftink, Cor – sequence: 8 givenname: Marieke surname: van de Ven fullname: van de Ven, Marieke – sequence: 9 givenname: Roderick L surname: Beijersbergen fullname: Beijersbergen, Roderick L – sequence: 10 givenname: Heinz orcidid: 0000-0001-6227-9850 surname: Jacobs fullname: Jacobs, Heinz – sequence: 11 givenname: Hein orcidid: 0000-0003-0255-4042 surname: te Riele fullname: te Riele, Hein email: h.t.riele@nki.nl |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39189458$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.ccr.2005.10.021 10.1038/s41586-022-04753-7 10.1016/j.devcel.2019.09.005 10.1038/nm0297-177 10.1371/journal.pgen.1009516 10.1038/s41586-022-04578-4 10.1038/s41467-021-21921-x 10.1002/wdev.189 10.7554/eLife.37868 10.1371/journal.pgen.1009184 10.1038/s41577-022-00772-7 10.1016/j.cell.2011.02.013 10.1002/ajmg.a.36887 10.1083/jcb.201808088 10.1038/s41586-022-04974-w 10.1038/s41586-020-2844-1 10.1016/j.immuni.2021.07.001 10.1038/nprot.2006.5 10.1073/pnas.1213021110 10.26508/lsa.202000668 10.1016/j.bbamcr.2020.118716 10.1016/j.celrep.2021.109500 10.1371/journal.pbio.0050123 10.1038/ni.1680 10.1038/nbt996 10.1093/bioinformatics/btt703 10.1261/rna.047787.114 10.1002/1873-3468.13591 10.1016/j.ebiom.2017.12.005 10.1038/ng.2414 10.4049/jimmunol.2000488 10.1091/mbc.12.5.1315 10.3389/fendo.2022.1058345 10.1083/jcb.140.6.1285 10.1038/s41591-018-0302-5 10.1016/j.devcel.2020.01.024 10.1186/s13059-014-0550-8 10.1016/j.cell.2017.12.016 10.1038/s41467-018-07824-4 10.1016/j.ccell.2022.11.014 10.1038/10049 10.1038/s41577-020-0288-3 10.1038/s43018-022-00393-y 10.1158/1541-7786.MCR-21-0604 10.1016/j.molcel.2014.05.007 10.1038/s41586-022-04878-9 10.1038/nbt.3437 10.1038/s41467-021-25790-2 10.1038/s41576-018-0006-1 10.1074/jbc.M306376200 10.1074/jbc.M203951200 10.15252/embj.2021109760 10.1074/jbc.RA119.007832 10.1038/s41588-018-0165-1 10.1016/j.cub.2015.01.053 10.1038/s41586-022-04896-7 10.4161/15384101.2015.945831 |
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| References | Kim (2024092307451028700_B39) 2019; 294 Zhang (2024092307451028700_B52) 2022; 606 Müllers (2024092307451028700_B42) 2014; 13 de Reuver (2024092307451028700_B6) 2021; 36 Jiang (2024092307451028700_B57) 2013; 110 Foijer (2024092307451028700_B3) 2005; 8 Shiromoto (2024092307451028700_B7) 2021; 12 Rehwinkel (2024092307451028700_B8) 2020; 20 Bielski (2024092307451028700_B37) 2018; 50 Stok (2024092307451028700_B48) 2022; 41 Hanahan (2024092307451028700_B1) 2011; 144 Blomberg (2024092307451028700_B16) 2023; 41 Baker (2024092307451028700_B27) 2022; 20 Gannon (2024092307451028700_B55) 2018; 9 Ahmad (2024092307451028700_B49) 2018; 172 Doench (2024092307451028700_B11) 2016; 34 Liu (2024092307451028700_B53) 2019; 25 Zielke (2024092307451028700_B25) 2015; 4 Gemble (2024092307451028700_B26) 2022; 604 Benedict (2024092307451028700_B2) 2018; 7 Garrido (2024092307451028700_B33) 2020; 16 Levanon (2024092307451028700_B5) 2004; 22 Clute (2024092307451028700_B31) 1999; 1 Nguyen (2024092307451028700_B36) 2002; 277 Hartner (2024092307451028700_B45) 2009; 10 Schweidenback (2024092307451028700_B40) 2015; 21 Chang (2024092307451028700_B41) 2003; 278 Krämer (2024092307451028700_B15) 2014; 30 Crow (2024092307451028700_B19) 2015; 167A Lara-Gonzalez (2024092307451028700_B30) 2019; 51 de Reuver (2024092307451028700_B24) 2022; 607 Benedict (2024092307451028700_B10) 2020; 52 Minton (2024092307451028700_B22) 2022; 22 Jackson (2024092307451028700_B13) 1998; 140 Olive (2024092307451028700_B12) 2006; 1 Jimeno (2024092307451028700_B17) 2021; 12 Benedict (2024092307451028700_B4) 2020; 3 Love (2024092307451028700_B14) 2014; 15 Yuan (2024092307451028700_B35) 2015; 25 Hayward (2024092307451028700_B44) 2019; 593 Szymczak (2024092307451028700_B28) 2022; 13 Helmlinger (2024092307451028700_B51) 1997; 3 Eisenberg (2024092307451028700_B47) 2018; 19 Krenning (2024092307451028700_B43) 2014; 55 Li (2024092307451028700_B34) 2019; 218 Sagredo (2024092307451028700_B29) 2020; 1867 Lindqvist (2024092307451028700_B32) 2007; 5 Jiao (2024092307451028700_B21) 2022; 607 Hubbard (2024092307451028700_B23) 2022; 607 Stok (2024092307451028700_B46) 2020; 205 Mehdipour (2024092307451028700_B54) 2020; 588 Sharpnack (2024092307451028700_B56) 2018; 27 Andreassen (2024092307451028700_B38) 2001; 12 Rice (2024092307451028700_B20) 2012; 44 Kim (2024092307451028700_B18) 2021; 17 Vaziri-Gohar (2024092307451028700_B50) 2022; 3 Maurano (2024092307451028700_B9) 2021; 54 |
| References_xml | – volume: 8 start-page: 455 year: 2005 ident: 2024092307451028700_B3 article-title: Mitogen requirement for cell cycle progression in the absence of pocket protein activity publication-title: Cancer Cell doi: 10.1016/j.ccr.2005.10.021 – volume: 606 start-page: 594 year: 2022 ident: 2024092307451028700_B52 article-title: ADAR1 Masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis publication-title: Nature doi: 10.1038/s41586-022-04753-7 – volume: 51 start-page: 313 year: 2019 ident: 2024092307451028700_B30 article-title: The G2-to-M transition is ensured by a dual mechanism that protects cyclin B from degradation by Cdc20-activated APC/C publication-title: Dev. Cell doi: 10.1016/j.devcel.2019.09.005 – volume: 3 start-page: 177 year: 1997 ident: 2024092307451028700_B51 article-title: Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation publication-title: Nat. Med. doi: 10.1038/nm0297-177 – volume: 17 start-page: e1009516 year: 2021 ident: 2024092307451028700_B18 article-title: RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1009516 – volume: 604 start-page: 146 year: 2022 ident: 2024092307451028700_B26 article-title: Genetic instability from a single S phase after whole-genome duplication publication-title: Nature doi: 10.1038/s41586-022-04578-4 – volume: 12 start-page: 1654 year: 2021 ident: 2024092307451028700_B7 article-title: ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells publication-title: Nat. Commun. doi: 10.1038/s41467-021-21921-x – volume: 4 start-page: 469 year: 2015 ident: 2024092307451028700_B25 article-title: FUCCI sensors: powerful new tools for analysis of cell proliferation publication-title: WIREs Dev. Biol. doi: 10.1002/wdev.189 – volume: 7 start-page: e37868 year: 2018 ident: 2024092307451028700_B2 article-title: Loss of P53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells publication-title: eLife doi: 10.7554/eLife.37868 – volume: 16 start-page: e1009184 year: 2020 ident: 2024092307451028700_B33 article-title: Cyclin B3 activates the anaphase-promoting complex/cyclosome in meiosis and mitosis publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1009184 – volume: 22 start-page: 531 year: 2022 ident: 2024092307451028700_B22 article-title: ZBP1 Induces immunopathology caused by loss of ADAR1-mediated RNA editing publication-title: Nat. Rev. Immunol. doi: 10.1038/s41577-022-00772-7 – volume: 144 start-page: 646 year: 2011 ident: 2024092307451028700_B1 article-title: Hallmarks of cancer: the next generation publication-title: Cell doi: 10.1016/j.cell.2011.02.013 – volume: 167A start-page: 296 year: 2015 ident: 2024092307451028700_B19 article-title: Characterization of Human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1 publication-title: Am. J. Med. Genet. A doi: 10.1002/ajmg.a.36887 – volume: 218 start-page: 1553 year: 2019 ident: 2024092307451028700_B34 article-title: Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I publication-title: J. Cell Biol. doi: 10.1083/jcb.201808088 – volume: 607 start-page: 784 year: 2022 ident: 2024092307451028700_B24 article-title: ADAR1 Prevents autoinflammation by suppressing spontaneous ZBP1 activation publication-title: Nature doi: 10.1038/s41586-022-04974-w – volume: 588 start-page: 169 year: 2020 ident: 2024092307451028700_B54 article-title: Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency publication-title: Nature doi: 10.1038/s41586-020-2844-1 – volume: 54 start-page: 1948 year: 2021 ident: 2024092307451028700_B9 article-title: Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1 publication-title: Immunity doi: 10.1016/j.immuni.2021.07.001 – volume: 1 start-page: 23 year: 2006 ident: 2024092307451028700_B12 article-title: The comet assay: a method to measure DNA damage in individual cells publication-title: Nat. Protoc. doi: 10.1038/nprot.2006.5 – volume: 110 start-page: 1041 year: 2013 ident: 2024092307451028700_B57 article-title: ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1213021110 – volume: 3 start-page: e202000668 year: 2020 ident: 2024092307451028700_B4 article-title: The RECQL helicase prevents replication fork collapse during replication stress publication-title: Life Sci. Alliance doi: 10.26508/lsa.202000668 – volume: 1867 start-page: 118716 year: 2020 ident: 2024092307451028700_B29 article-title: ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage response publication-title: Biochim. Biophys. Acta. Mol. Cell Res. doi: 10.1016/j.bbamcr.2020.118716 – volume: 36 start-page: 109500 year: 2021 ident: 2024092307451028700_B6 article-title: ADAR1 Interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation publication-title: Cell Rep. doi: 10.1016/j.celrep.2021.109500 – volume: 5 start-page: e123 year: 2007 ident: 2024092307451028700_B32 article-title: Cyclin B1–Cdk1 activation continues after centrosome separation to control mitotic progression publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0050123 – volume: 10 start-page: 109 year: 2009 ident: 2024092307451028700_B45 article-title: ADAR1 Is essential for the maintenance of hematopoiesis and suppression of interferon signaling publication-title: Nat. Immunol. doi: 10.1038/ni.1680 – volume: 22 start-page: 1001 year: 2004 ident: 2024092307451028700_B5 article-title: Systematic identification of abundant A-to-I editing sites in the Human transcriptome publication-title: Nat. Biotechnol. doi: 10.1038/nbt996 – volume: 30 start-page: 523 year: 2014 ident: 2024092307451028700_B15 article-title: Causal analysis approaches in ingenuity pathway analysis publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt703 – volume: 21 start-page: 279 year: 2015 ident: 2024092307451028700_B40 article-title: Evidence for multiple, distinct ADAR-containing complexes in Xenopus Laevis publication-title: RNA doi: 10.1261/rna.047787.114 – volume: 593 start-page: 2889 year: 2019 ident: 2024092307451028700_B44 article-title: Orchestration of the spindle assembly checkpoint by CDK1-cyclin B1 publication-title: FEBS Lett. doi: 10.1002/1873-3468.13591 – volume: 27 start-page: 167 year: 2018 ident: 2024092307451028700_B56 article-title: Global transcriptome analysis of RNA abundance regulation by ADAR in lung adenocarcinoma publication-title: EBioMedicine doi: 10.1016/j.ebiom.2017.12.005 – volume: 44 start-page: 1243 year: 2012 ident: 2024092307451028700_B20 article-title: Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature publication-title: Nat. Genet. doi: 10.1038/ng.2414 – volume: 205 start-page: 883 year: 2020 ident: 2024092307451028700_B46 article-title: Self RNA sensing by RIG-I-like receptors in viral infection and sterile inflammation publication-title: J. Immunol. doi: 10.4049/jimmunol.2000488 – volume: 12 start-page: 1315 year: 2001 ident: 2024092307451028700_B38 article-title: Tetraploid State induces P53-dependent arrest of nontransformed mammalian cells in G1 publication-title: Mol. Biol. Cell doi: 10.1091/mbc.12.5.1315 – volume: 13 start-page: 1058345 year: 2022 ident: 2024092307451028700_B28 article-title: ADAR1-Dependent editing regulates Human beta cell transcriptome diversity during inflammation publication-title: Front. Endocrinol. (Lausanne) doi: 10.3389/fendo.2022.1058345 – volume: 140 start-page: 1285 year: 1998 ident: 2024092307451028700_B13 article-title: Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in Human cells publication-title: J. Cell Biol. doi: 10.1083/jcb.140.6.1285 – volume: 25 start-page: 95 year: 2019 ident: 2024092307451028700_B53 article-title: Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss publication-title: Nat. Med. doi: 10.1038/s41591-018-0302-5 – volume: 52 start-page: 683 year: 2020 ident: 2024092307451028700_B10 article-title: WAPL-dependent repair of damaged DNA replication forks underlies oncogene-induced loss of sister chromatid cohesion publication-title: Dev. Cell doi: 10.1016/j.devcel.2020.01.024 – volume: 15 start-page: 550 year: 2014 ident: 2024092307451028700_B14 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol. doi: 10.1186/s13059-014-0550-8 – volume: 172 start-page: 797 year: 2018 ident: 2024092307451028700_B49 article-title: Breaching self-tolerance to Alu duplex RNA underlies MDA5-mediated inflammation publication-title: Cell doi: 10.1016/j.cell.2017.12.016 – volume: 9 start-page: 5450 year: 2018 ident: 2024092307451028700_B55 article-title: Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells publication-title: Nat. Commun. doi: 10.1038/s41467-018-07824-4 – volume: 41 start-page: 106 year: 2023 ident: 2024092307451028700_B16 article-title: IL-5-producing CD4(+) T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer publication-title: Cancer Cell doi: 10.1016/j.ccell.2022.11.014 – volume: 1 start-page: 82 year: 1999 ident: 2024092307451028700_B31 article-title: Temporal and spatial control of Cyclin B1 destruction in Metaphase publication-title: Nat. Cell Biol. doi: 10.1038/10049 – volume: 20 start-page: 537 year: 2020 ident: 2024092307451028700_B8 article-title: RIG-I-like receptors: their regulation and roles in RNA sensing publication-title: Nat. Rev. Immunol. doi: 10.1038/s41577-020-0288-3 – volume: 3 start-page: 852 year: 2022 ident: 2024092307451028700_B50 article-title: Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors publication-title: Nat Cancer doi: 10.1038/s43018-022-00393-y – volume: 20 start-page: 960 year: 2022 ident: 2024092307451028700_B27 article-title: Transcriptome profiling of ADAR1 targets in triple-negative breast cancer cells reveals mechanisms for regulating growth and invasion publication-title: Mol. Cancer Res. doi: 10.1158/1541-7786.MCR-21-0604 – volume: 55 start-page: 59 year: 2014 ident: 2024092307451028700_B43 article-title: Transient activation of P53 in G2 phase is sufficient to induce senescence publication-title: Mol. Cell doi: 10.1016/j.molcel.2014.05.007 – volume: 607 start-page: 776 year: 2022 ident: 2024092307451028700_B21 article-title: ADAR1 Averts fatal type I interferon induction by ZBP1 publication-title: Nature doi: 10.1038/s41586-022-04878-9 – volume: 34 start-page: 184 year: 2016 ident: 2024092307451028700_B11 article-title: Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3437 – volume: 12 start-page: 5512 year: 2021 ident: 2024092307451028700_B17 article-title: ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair publication-title: Nat. Commun. doi: 10.1038/s41467-021-25790-2 – volume: 19 start-page: 473 year: 2018 ident: 2024092307451028700_B47 article-title: A-to-I RNA editing - immune protector and transcriptome diversifier publication-title: Nat. Rev. Genet. doi: 10.1038/s41576-018-0006-1 – volume: 278 start-page: 37865 year: 2003 ident: 2024092307451028700_B41 article-title: Degradation of cyclin B is required for the onset of anaphase in mammalian cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.M306376200 – volume: 277 start-page: 41960 year: 2002 ident: 2024092307451028700_B36 article-title: Characterization and expression of mammalian cyclin B3, a prepachytene meiotic cyclin * publication-title: J. Biol. Chem. doi: 10.1074/jbc.M203951200 – volume: 41 start-page: e109760 year: 2022 ident: 2024092307451028700_B48 article-title: RNA sensing via the RIG-I-like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency publication-title: EMBO J. doi: 10.15252/embj.2021109760 – volume: 294 start-page: 8760 year: 2019 ident: 2024092307451028700_B39 article-title: Systematic proteomics of endogenous Human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression publication-title: J. Biol. Chem. doi: 10.1074/jbc.RA119.007832 – volume: 50 start-page: 1189 year: 2018 ident: 2024092307451028700_B37 article-title: Genome doubling shapes the evolution and prognosis of advanced cancers publication-title: Nat. Genet. doi: 10.1038/s41588-018-0165-1 – volume: 25 start-page: 811 year: 2015 ident: 2024092307451028700_B35 article-title: Cyclin B3 is a mitotic Cyclin that promotes the metaphase-anaphase transition publication-title: Curr. Biol. doi: 10.1016/j.cub.2015.01.053 – volume: 607 start-page: 769 year: 2022 ident: 2024092307451028700_B23 article-title: ADAR1 Mutation causes ZBP1-dependent immunopathology publication-title: Nature doi: 10.1038/s41586-022-04896-7 – volume: 13 start-page: 2733 year: 2014 ident: 2024092307451028700_B42 article-title: Nuclear translocation of cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase publication-title: Cell Cycle doi: 10.4161/15384101.2015.945831 |
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