Severe Arboviral Neuroinvasive Disease in Patients on Rituximab Therapy: A Review
With increasing use of rituximab and other B-cell depleting monoclonal antibodies for multiple indications, infectious complications are being recognized. We summarize clinical findings of patients on rituximab with arboviral diseases identified through literature review or consultation with the Cen...
Saved in:
| Published in: | Clinical infectious diseases Vol. 76; no. 6; p. 1142 |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
21.03.2023
|
| Subjects: | |
| ISSN: | 1537-6591, 1537-6591 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | With increasing use of rituximab and other B-cell depleting monoclonal antibodies for multiple indications, infectious complications are being recognized. We summarize clinical findings of patients on rituximab with arboviral diseases identified through literature review or consultation with the Centers for Disease Control and Prevention. We identified 21 patients on recent rituximab therapy who were diagnosed with an arboviral disease caused by West Nile, tick-borne encephalitis, eastern equine encephalitis, Cache Valley, Jamestown Canyon, and Powassan viruses. All reported patients had neuroinvasive disease. The diagnosis of arboviral infection required molecular testing in 20 (95%) patients. Median illness duration was 36 days (range, 12 days to 1 year), and 15/19 (79%) patients died from their illness. Patients on rituximab with arboviral disease can have a severe or prolonged course with an absence of serologic response. Patients should be counseled about mosquito and tick bite prevention when receiving rituximab and other B-cell depleting therapies. |
|---|---|
| AbstractList | With increasing use of rituximab and other B-cell depleting monoclonal antibodies for multiple indications, infectious complications are being recognized. We summarize clinical findings of patients on rituximab with arboviral diseases identified through literature review or consultation with the Centers for Disease Control and Prevention. We identified 21 patients on recent rituximab therapy who were diagnosed with an arboviral disease caused by West Nile, tick-borne encephalitis, eastern equine encephalitis, Cache Valley, Jamestown Canyon, and Powassan viruses. All reported patients had neuroinvasive disease. The diagnosis of arboviral infection required molecular testing in 20 (95%) patients. Median illness duration was 36 days (range, 12 days to 1 year), and 15/19 (79%) patients died from their illness. Patients on rituximab with arboviral disease can have a severe or prolonged course with an absence of serologic response. Patients should be counseled about mosquito and tick bite prevention when receiving rituximab and other B-cell depleting therapies. With increasing use of rituximab and other B-cell depleting monoclonal antibodies for multiple indications, infectious complications are being recognized. We summarize clinical findings of patients on rituximab with arboviral diseases identified through literature review or consultation with the Centers for Disease Control and Prevention. We identified 21 patients on recent rituximab therapy who were diagnosed with an arboviral disease caused by West Nile, tick-borne encephalitis, eastern equine encephalitis, Cache Valley, Jamestown Canyon, and Powassan viruses. All reported patients had neuroinvasive disease. The diagnosis of arboviral infection required molecular testing in 20 (95%) patients. Median illness duration was 36 days (range, 12 days to 1 year), and 15/19 (79%) patients died from their illness. Patients on rituximab with arboviral disease can have a severe or prolonged course with an absence of serologic response. Patients should be counseled about mosquito and tick bite prevention when receiving rituximab and other B-cell depleting therapies.With increasing use of rituximab and other B-cell depleting monoclonal antibodies for multiple indications, infectious complications are being recognized. We summarize clinical findings of patients on rituximab with arboviral diseases identified through literature review or consultation with the Centers for Disease Control and Prevention. We identified 21 patients on recent rituximab therapy who were diagnosed with an arboviral disease caused by West Nile, tick-borne encephalitis, eastern equine encephalitis, Cache Valley, Jamestown Canyon, and Powassan viruses. All reported patients had neuroinvasive disease. The diagnosis of arboviral infection required molecular testing in 20 (95%) patients. Median illness duration was 36 days (range, 12 days to 1 year), and 15/19 (79%) patients died from their illness. Patients on rituximab with arboviral disease can have a severe or prolonged course with an absence of serologic response. Patients should be counseled about mosquito and tick bite prevention when receiving rituximab and other B-cell depleting therapies. |
| Author | Khan, Ezza Velez, Jason O Brault, Aaron Gill, Christine M Fischer, Marc Gould, Carolyn V Hughes, Holly R Pastula, Daniel M Panella, Amanda Kapadia, Ronak K Laven, Janeen J Staples, J Erin |
| Author_xml | – sequence: 1 givenname: Ronak K surname: Kapadia fullname: Kapadia, Ronak K organization: Division of Neurology, Department of Clinical Neurosciences, Cummings School of Medicine, University of Calgary, Calgary, Alberta, Canada – sequence: 2 givenname: J Erin surname: Staples fullname: Staples, J Erin organization: Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA – sequence: 3 givenname: Christine M surname: Gill fullname: Gill, Christine M organization: University of Iowa, Carver College of Medicine, Department of Neurology, Iowa City, Iowa, USA – sequence: 4 givenname: Marc surname: Fischer fullname: Fischer, Marc organization: Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA – sequence: 5 givenname: Ezza surname: Khan fullname: Khan, Ezza organization: Hunterdon Infectious Disease Specialists, Flemington, New Jersey, USA – sequence: 6 givenname: Janeen J surname: Laven fullname: Laven, Janeen J organization: Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA – sequence: 7 givenname: Amanda surname: Panella fullname: Panella, Amanda organization: Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA – sequence: 8 givenname: Jason O surname: Velez fullname: Velez, Jason O organization: Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA – sequence: 9 givenname: Holly R surname: Hughes fullname: Hughes, Holly R organization: Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA – sequence: 10 givenname: Aaron surname: Brault fullname: Brault, Aaron organization: Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA – sequence: 11 givenname: Daniel M surname: Pastula fullname: Pastula, Daniel M organization: Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado, USA – sequence: 12 givenname: Carolyn V surname: Gould fullname: Gould, Carolyn V organization: Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36103602$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkElPwzAUhC1URBc4cUc-cgnYcZyFW1VWqWIp5Rw928_CKE2CnQT676lEkTiMZg6fRqOZklHd1EjIKWcXnBXiUjuzE-gsTQ_IhEuRRaks-OhfHpNpCB-McZ4zeUTGIuVMpCyekJdXHNAjnXvVDM5DRR-x942rBwhuQHrtAkJA6mr6DJ3Dugu0qenKdf2324Ci63f00G6v6JyucHD4dUwOLVQBT_Y-I2-3N-vFfbR8untYzJeRTrjoImAiszYGWRgmsxwSo61IczAcMi1Qc8msEEJZVaAyhhdWMQNG5lmS21hgPCPnv72tbz57DF25cUFjVUGNTR_KOONJKqXkfIee7dFebdCUrd9N99vy74b4Bw81YaA |
| CitedBy_id | crossref_primary_10_1128_cmr_00232_24 crossref_primary_10_3201_eid3102_240831 crossref_primary_10_1016_j_bioelechem_2023_108540 crossref_primary_10_1128_spectrum_00902_24 crossref_primary_10_1177_13524585241237396 crossref_primary_10_1093_jme_tjad058 crossref_primary_10_1007_s11908_024_00843_x crossref_primary_10_1093_ofid_ofaf379 crossref_primary_10_3201_eid3010_240595 crossref_primary_10_1056_NEJMcpc2412528 crossref_primary_10_1093_jnen_nlaf009 crossref_primary_10_1212_NXI_0000000000200154 crossref_primary_10_1001_jama_2025_8737 crossref_primary_10_1097_WCO_0000000000001155 crossref_primary_10_1093_infdis_jiae197 crossref_primary_10_7759_cureus_40222 crossref_primary_10_1155_crdi_4453384 crossref_primary_10_3390_v16111653 crossref_primary_10_3390_microorganisms11071634 crossref_primary_10_1093_infdis_jiaf182 crossref_primary_10_15585_mmwr_rr7205a1 crossref_primary_10_1177_20499361251313827 crossref_primary_10_1097_QCO_0000000000001108 crossref_primary_10_1177_20499361241274246 |
| ContentType | Journal Article |
| Copyright | Published by Oxford University Press on behalf of Infectious Diseases Society of America 2022. |
| Copyright_xml | – notice: Published by Oxford University Press on behalf of Infectious Diseases Society of America 2022. |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1093/cid/ciac766 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1537-6591 |
| ExternalDocumentID | 36103602 |
| Genre | Research Support, U.S. Gov't, P.H.S Journal Article Review |
| GrantInformation_xml | – fundername: Intramural CDC HHS grantid: CC999999 |
| GroupedDBID | --- ..I .2P .I3 .ZR 08P 0R~ 29B 2WC 36B 4.4 48X 53G 5GY 5RE 5VS 5WD 6J9 70D AABZA AACGO AACZT AAJKP AAMVS AANCE AAOGV AAPNW AAPQZ AAPXW AAQQT AARHZ AAUAY AAVAP ABDFA ABEJV ABEUO ABGNP ABIXL ABJNI ABKDP ABLJU ABNHQ ABNKS ABOCM ABPLY ABPQP ABPTD ABQLI ABQNK ABTLG ABVGC ABWST ABXVV ABZBJ ACGFO ACGFS ACPRK ACUFI ACUTO ACYHN ADBBV ADEYI ADGZP ADHKW ADHZD ADIPN ADNBA ADOCK ADQBN ADRTK ADVEK ADYVW ADZXQ AEGPL AEGXH AEJOX AEKSI AEMDU AEMQT AENEX AENZO AEPUE AETBJ AEWNT AFFZL AFIYH AFOFC AFRAH AFXAL AFYAG AGINJ AGKEF AGORE AGQXC AGSYK AGUTN AHGBF AHMBA AHMMS AHXPO AIAGR AIJHB AJBYB AJEEA AJNCP ALMA_UNASSIGNED_HOLDINGS ALUQC ALXQX APIBT APWMN AQKUS ATGXG AXUDD BAWUL BAYMD BCRHZ BEYMZ BHONS BTRTY BVRKM C45 CDBKE CGR CS3 CUY CVF CZ4 DAKXR DIK DILTD DU5 D~K E3Z EBS ECM EE~ EIF EMOBN ENERS F5P F9B FECEO FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC H13 H5~ HAR HW0 HZ~ IOX J21 JLS JSG JXSIZ KAQDR KOP KSI KSN L7B MHKGH MJL ML0 N9A NGC NOMLY NOYVH NPM NU- O9- OAUYM OAWHX OCZFY ODMLO ODZKP OJQWA OJZSN OK1 OPAEJ OVD OWPYF P2P P6G PAFKI PEELM PQQKQ Q1. Q5Y RD5 ROX ROZ RUSNO RW1 RXO SJN TCURE TEORI TJX TMA TR2 W8F X7H YAYTL YKOAZ YXANX ~91 ~S- 7X8 |
| ID | FETCH-LOGICAL-c413t-a037ff2a59d0578a4dcf368ad1a7c3ec150f333bfb9ebdd19fb0dad58748f23e2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 28 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000865108200001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1537-6591 |
| IngestDate | Sun Nov 09 12:30:47 EST 2025 Mon Jul 21 06:07:58 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | anti-CD20 arboviral disease rituximab arbovirus monoclonal antibodies |
| Language | English |
| License | Published by Oxford University Press on behalf of Infectious Diseases Society of America 2022. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c413t-a037ff2a59d0578a4dcf368ad1a7c3ec150f333bfb9ebdd19fb0dad58748f23e2 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| OpenAccessLink | https://pmc.ncbi.nlm.nih.gov/articles/PMC10011006/pdf/nihms-1844190.pdf |
| PMID | 36103602 |
| PQID | 2714655511 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2714655511 pubmed_primary_36103602 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-03-21 |
| PublicationDateYYYYMMDD | 2023-03-21 |
| PublicationDate_xml | – month: 03 year: 2023 text: 2023-03-21 day: 21 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Clinical infectious diseases |
| PublicationTitleAlternate | Clin Infect Dis |
| PublicationYear | 2023 |
| SSID | ssj0011805 |
| Score | 2.5384357 |
| SecondaryResourceType | review_article |
| Snippet | With increasing use of rituximab and other B-cell depleting monoclonal antibodies for multiple indications, infectious complications are being recognized. We... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 1142 |
| SubjectTerms | Animals Arbovirus Infections Disease Outbreaks Encephalitis, Tick-Borne - epidemiology Rituximab - therapeutic use West Nile Fever - complications West Nile Fever - drug therapy West Nile Fever - epidemiology |
| Title | Severe Arboviral Neuroinvasive Disease in Patients on Rituximab Therapy: A Review |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/36103602 https://www.proquest.com/docview/2714655511 |
| Volume | 76 |
| WOSCitedRecordID | wos000865108200001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3LSsNAFB3Uirjx_agvRnA7tMkkkxk3UtTipqVqhe7CPCGgSTVt8fO9k6R040Jwk1UCyc2duWfmnDkXoZtQhjzWmhNf20iklSEidoywSCoDcMEy56pmE8lwyCcTMWo23MpGVrmcE6uJ2hTa75F3wiTwVl-AD-6mn8R3jfLsatNCYx21KEAZL-lKJisWIeCVhBEGdUJYLILmfB4s4jsafjV8vF7aI_6KLasa09_979vtoZ0GXeJenQ77aM3mB2hr0PDnh-j51ULqWrhBFV7d-44rc44sX0gvY8cPNV2DsxyPasPVEhc5fslm8-_sQyo8rk0IbnEP16zCEXrrP47vn0jTVIFoqFczIrs0cS6UsTAA1biMjHaUcWkCmWhqNQBERylVTgmrjAmEU10jTcyTiLuQ2vAYbeRFbk8R1sxxFcUm4bDmcoaKKI4tFcwa5ZiToo2ul8FKIWk9EyFzW8zLdBWuNjqpI55Oa3eNlAKgo6wbnv3h6XO07du_e01YGFygloMhay_Rpl7MsvLrqsoGuA5Hgx_yO8FD |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Severe+Arboviral+Neuroinvasive+Disease+in+Patients+on+Rituximab+Therapy%3A+A+Review&rft.jtitle=Clinical+infectious+diseases&rft.au=Kapadia%2C+Ronak+K&rft.au=Staples%2C+J+Erin&rft.au=Gill%2C+Christine+M&rft.au=Fischer%2C+Marc&rft.date=2023-03-21&rft.eissn=1537-6591&rft.volume=76&rft.issue=6&rft.spage=1142&rft_id=info:doi/10.1093%2Fcid%2Fciac766&rft_id=info%3Apmid%2F36103602&rft_id=info%3Apmid%2F36103602&rft.externalDocID=36103602 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1537-6591&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1537-6591&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1537-6591&client=summon |